BRD-K79222491_2-morpholino-9-(thiophen-3-yl)-N-((5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)methyl)-9H-purin-6-amine_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

103 genes differentially expressed following the BRD-K79222491_2-morpholino-9-(thiophen-3-yl)-N-((5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)methyl)-9H-purin-6-amine_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
AEBP1 AE binding protein 1
AGTR1 angiotensin II receptor, type 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDOB aldolase B, fructose-bisphosphate
AQP9 aquaporin 9
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
C7 complement component 7
CFB complement factor B
CFH complement factor H
CLU clusterin
COL3A1 collagen, type III, alpha 1
CPM carboxypeptidase M
CRIP2 cysteine-rich protein 2
CRYAB crystallin, alpha B
DUSP1 dual specificity phosphatase 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FABP1 fatty acid binding protein 1, liver
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1R1 interleukin 1 receptor, type I
KIAA0226L KIAA0226-like
L1CAM L1 cell adhesion molecule
LAPTM4B lysosomal protein transmembrane 4 beta
NFASC neurofascin
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
PCSK5 proprotein convertase subtilisin/kexin type 5
PSENEN presenilin enhancer gamma secretase subunit
RNASE6 ribonuclease, RNase A family, k6
SELENBP1 selenium binding protein 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
TUBA1A tubulin, alpha 1a

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BLCAP bladder cancer associated protein
CASP3 caspase 3, apoptosis-related cysteine peptidase
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNE1 cyclin E1
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDK7 cyclin-dependent kinase 7
CHERP calcium homeostasis endoplasmic reticulum protein
COIL coilin
CRNKL1 crooked neck pre-mRNA splicing factor 1
DBF4 DBF4 zinc finger
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DUSP4 dual specificity phosphatase 4
DUSP7 dual specificity phosphatase 7
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
GINS1 GINS complex subunit 1 (Psf1 homolog)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOXA1 homeobox A1
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JMJD6 jumonji domain containing 6
KAT6A K(lysine) acetyltransferase 6A
KEAP1 kelch-like ECH-associated protein 1
KIAA0907 KIAA0907
KYNU kynureninase
LTN1 listerin E3 ubiquitin protein ligase 1
MSL2 male-specific lethal 2 homolog (Drosophila)
MTF2 metal response element binding transcription factor 2
MTPAP mitochondrial poly(A) polymerase
NET1 neuroepithelial cell transforming 1
NGDN neuroguidin, EIF4E binding protein
NUP62 nucleoporin 62kDa
NXT1 nuclear transport factor 2-like export factor 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAGL2 pleiomorphic adenoma gene-like 2
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPARG peroxisome proliferator-activated receptor gamma
RBM15 RNA binding motif protein 15
RLF rearranged L-myc fusion
RNF219 ring finger protein 219
RNMT RNA (guanine-7-) methyltransferase
RRP1B ribosomal RNA processing 1B
RSRC2 arginine/serine-rich coiled-coil 2
SCGB2A2 secretoglobin, family 2A, member 2
SERTAD2 SERTA domain containing 2
SMAD3 SMAD family member 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TBP TATA box binding protein
TFF3 trefoil factor 3 (intestinal)
TICAM1 toll-like receptor adaptor molecule 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TSC22D2 TSC22 domain family, member 2
UBXN7 UBX domain protein 7
YTHDC1 YTH domain containing 1
ZCCHC8 zinc finger, CCHC domain containing 8