BRD-K79222491_2-morpholino-9-(thiophen-3-yl)-N-((5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)methyl)-9H-purin-6-amine_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

367 genes differentially expressed following the BRD-K79222491_2-morpholino-9-(thiophen-3-yl)-N-((5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)methyl)-9H-purin-6-amine_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADH6 alcohol dehydrogenase 6 (class V)
AHCY adenosylhomocysteinase
AK5 adenylate kinase 5
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALB albumin
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDOB aldolase B, fructose-bisphosphate
AMBP alpha-1-microglobulin/bikunin precursor
AOX1 aldehyde oxidase 1
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ASGR2 asialoglycoprotein receptor 2
ASPN asporin
ATF3 activating transcription factor 3
ATRNL1 attractin-like 1
BEX1 brain expressed, X-linked 1
C5AR1 complement component 5a receptor 1
C9ORF16 chromosome 9 open reading frame 16
CA2 carbonic anhydrase II
CA4 carbonic anhydrase IV
CADM1 cell adhesion molecule 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCDC85B coiled-coil domain containing 85B
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CECR1 cat eye syndrome chromosome region, candidate 1
CLC Charcot-Leyden crystal galectin
CLEC4A C-type lectin domain family 4, member A
CLEC7A C-type lectin domain family 7, member A
COL3A1 collagen, type III, alpha 1
COLEC11 collectin sub-family member 11
CPE carboxypeptidase E
CRIP2 cysteine-rich protein 2
CSTA cystatin A (stefin A)
CTGF connective tissue growth factor
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CYBA cytochrome b-245, alpha polypeptide
CYTIP cytohesin 1 interacting protein
DCN decorin
DEFA4 defensin, alpha 4, corticostatin
DIO1 deiodinase, iodothyronine, type I
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNM1 dynamin 1
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DPYSL3 dihydropyrimidinase-like 3
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5A eukaryotic translation initiation factor 5A
ELANE elastase, neutrophil expressed
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EREG epiregulin
FABP1 fatty acid binding protein 1, liver
FAM198B family with sequence similarity 198, member B
FGFR3 fibroblast growth factor receptor 3
FGL2 fibrinogen-like 2
FILIP1L filamin A interacting protein 1-like
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXF1 forkhead box F1
FRY furry homolog (Drosophila)
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAGE3 G antigen 3
GLT8D2 glycosyltransferase 8 domain containing 2
GLUD1 glutamate dehydrogenase 1
GPM6A glycoprotein M6A
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HBB hemoglobin, beta
HCAR3 hydroxycarboxylic acid receptor 3
HEG1 heart development protein with EGF-like domains 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGN4 high mobility group nucleosomal binding domain 4
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IL1R1 interleukin 1 receptor, type I
IL7R interleukin 7 receptor
INHBA inhibin, beta A
ISG15 ISG15 ubiquitin-like modifier
ISYNA1 inositol-3-phosphate synthase 1
ITGB7 integrin, beta 7
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
JUNB jun B proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0226L KIAA0226-like
KRT5 keratin 5, type II
LAMP3 lysosomal-associated membrane protein 3
LAMP5 lysosomal-associated membrane protein family, member 5
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LRRC17 leucine rich repeat containing 17
LYZ lysozyme
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
METTL7A methyltransferase like 7A
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MPO myeloperoxidase
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NR4A2 nuclear receptor subfamily 4, group A, member 2
ORM1 orosomucoid 1
PAH phenylalanine hydroxylase
PCBP2 poly(rC) binding protein 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG3 paternally expressed 3
PID1 phosphotyrosine interaction domain containing 1
PLCL1 phospholipase C-like 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PRAME preferentially expressed antigen in melanoma
PRR7 proline rich 7 (synaptic)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRO protein tyrosine phosphatase, receptor type, O
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS5 regulator of G-protein signaling 5
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RTN1 reticulon 1
SCG2 secretogranin II
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SFRP4 secreted frizzled-related protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SNN stannin
SOX4 SRY (sex determining region Y)-box 4
STC1 stanniocalcin 1
SULF1 sulfatase 1
TCF21 transcription factor 21
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TEK TEK tyrosine kinase, endothelial
TF transferrin
THBS1 thrombospondin 1
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TMSB15A thymosin beta 15a
TRIM2 tripartite motif containing 2
TSPAN7 tetraspanin 7
TUSC3 tumor suppressor candidate 3
VNN1 vanin 1
VSNL1 visinin-like 1
WLS wntless Wnt ligand secretion mediator
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACBD3 acyl-CoA binding domain containing 3
ACSL1 acyl-CoA synthetase long-chain family member 1
ACSL3 acyl-CoA synthetase long-chain family member 3
AK1 adenylate kinase 1
AKAP10 A kinase (PRKA) anchor protein 10
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BIN1 bridging integrator 1
BLCAP bladder cancer associated protein
BLM Bloom syndrome, RecQ helicase-like
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C14ORF166 chromosome 14 open reading frame 166
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CAPN6 calpain 6
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CD164 CD164 molecule, sialomucin
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDK1 cyclin-dependent kinase 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CGRRF1 cell growth regulator with ring finger domain 1
CIT citron rho-interacting serine/threonine kinase
CLTC clathrin, heavy chain (Hc)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CTBP2 C-terminal binding protein 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCK deoxycytidine kinase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DUSP4 dual specificity phosphatase 4
ECD ecdysoneless homolog (Drosophila)
EIF4E eukaryotic translation initiation factor 4E
ERH enhancer of rudimentary homolog (Drosophila)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP7 fatty acid binding protein 7, brain
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GABPB1 GA binding protein transcription factor, beta subunit 1
GLOD4 glyoxalase domain containing 4
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GOLPH3L golgi phosphoprotein 3-like
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSTA4 glutathione S-transferase alpha 4
H1F0 H1 histone family, member 0
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC6 homeobox C6
HSPA14 heat shock 70kDa protein 14
IDI1 isopentenyl-diphosphate delta isomerase 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IST1 increased sodium tolerance 1 homolog (yeast)
ITPKB inositol-trisphosphate 3-kinase B
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KLK11 kallikrein-related peptidase 11
KPNB1 karyopherin (importin) beta 1
KRT7 keratin 7, type II
LBR lamin B receptor
LIMA1 LIM domain and actin binding 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LTF lactotransferrin
MAPK6 mitogen-activated protein kinase 6
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MED6 mediator complex subunit 6
MGLL monoglyceride lipase
MPRIP myosin phosphatase Rho interacting protein
MPZL1 myelin protein zero-like 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYBPC1 myosin binding protein C, slow type
MYO1E myosin IE
NKX3-1 NK3 homeobox 1
NMI N-myc (and STAT) interactor
NNMT nicotinamide N-methyltransferase
NOTCH2 notch 2
NPAS2 neuronal PAS domain protein 2
NPY neuropeptide Y
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUP43 nucleoporin 43kDa
NUP54 nucleoporin 54kDa
NUP62 nucleoporin 62kDa
NUPL1 nucleoporin like 1
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PFKP phosphofructokinase, platelet
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIP prolactin-induced protein
PKM pyruvate kinase, muscle
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRKCD protein kinase C, delta
PRKCDBP protein kinase C, delta binding protein
PROM1 prominin 1
PRPF4 pre-mRNA processing factor 4
PRRC2C proline-rich coiled-coil 2C
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMG2 proteasome (prosome, macropain) assembly chaperone 2
PTGES prostaglandin E synthase
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAB22A RAB22A, member RAS oncogene family
RAE1 ribonucleic acid export 1
RBPMS RNA binding protein with multiple splicing
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RHOF ras homolog family member F (in filopodia)
RNMT RNA (guanine-7-) methyltransferase
RNPS1 RNA binding protein S1, serine-rich domain
RPL36AL ribosomal protein L36a-like
RPS11 ribosomal protein S11
RREB1 ras responsive element binding protein 1
RRP1B ribosomal RNA processing 1B
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SCEL sciellin
SEC24A SEC24 family member A
SERTAD2 SERTA domain containing 2
SIX1 SIX homeobox 1
SIX2 SIX homeobox 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC35F2 solute carrier family 35, member F2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SMCO4 single-pass membrane protein with coiled-coil domains 4
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SNUPN snurportin 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SREBF1 sterol regulatory element binding transcription factor 1
SRPX sushi-repeat containing protein, X-linked
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYPL1 synaptophysin-like 1
TACC3 transforming, acidic coiled-coil containing protein 3
TBC1D4 TBC1 domain family, member 4
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TBL1X transducin (beta)-like 1X-linked
TCERG1 transcription elongation regulator 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFF1 trefoil factor 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM11 transmembrane protein 11
TMX4 thioredoxin-related transmembrane protein 4
TNC tenascin C
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNPO1 transportin 1
TNS3 tensin 3
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TRAPPC3 trafficking protein particle complex 3
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSPYL5 TSPY-like 5
TXLNA taxilin alpha
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE3A ubiquitin protein ligase E3A
UBXN7 UBX domain protein 7
USP22 ubiquitin specific peptidase 22
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
VRK1 vaccinia related kinase 1
WDR61 WD repeat domain 61
WDR82 WD repeat domain 82
XPO7 exportin 7
YBX3 Y box binding protein 3
YTHDC1 YTH domain containing 1
ZC3H11A zinc finger CCCH-type containing 11A
ZFAND6 zinc finger, AN1-type domain 6
ZMYM2 zinc finger, MYM-type 2
ZNF185 zinc finger protein 185 (LIM domain)
ZNF22 zinc finger protein 22
ZWILCH zwilch kinetochore protein