BRD-K79222491_2-morpholino-9-(thiophen-3-yl)-N-((5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)methyl)-9H-purin-6-amine_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

178 genes differentially expressed following the BRD-K79222491_2-morpholino-9-(thiophen-3-yl)-N-((5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)methyl)-9H-purin-6-amine_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AEBP1 AE binding protein 1
AIDA axin interactor, dorsalization associated
ALCAM activated leukocyte cell adhesion molecule
AREG amphiregulin
ATP10B ATPase, class V, type 10B
ATP7A ATPase, Cu++ transporting, alpha polypeptide
BCHE butyrylcholinesterase
BHLHE41 basic helix-loop-helix family, member e41
BLNK B-cell linker
BPGM 2,3-bisphosphoglycerate mutase
BTG2 BTG family, member 2
CA4 carbonic anhydrase IV
CALD1 caldesmon 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD24 CD24 molecule
CD47 CD47 molecule
CDKN2A cyclin-dependent kinase inhibitor 2A
CECR1 cat eye syndrome chromosome region, candidate 1
CHGB chromogranin B
CLIC4 chloride intracellular channel 4
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COLEC12 collectin sub-family member 12
CXADR coxsackie virus and adenovirus receptor
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DPYD dihydropyrimidine dehydrogenase
EMP1 epithelial membrane protein 1
ESM1 endothelial cell-specific molecule 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM149A family with sequence similarity 149, member A
FCGBP Fc fragment of IgG binding protein
FHL1 four and a half LIM domains 1
GADD45B growth arrest and DNA-damage-inducible, beta
GPR183 G protein-coupled receptor 183
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IFT57 intraflagellar transport 57
INA internexin neuronal intermediate filament protein, alpha
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JAG1 jagged 1
KRT20 keratin 20, type I
LAPTM5 lysosomal protein transmembrane 5
LPL lipoprotein lipase
MAOA monoamine oxidase A
MDFIC MyoD family inhibitor domain containing
MSN moesin
NELL2 NEL-like 2 (chicken)
NLGN4X neuroligin 4, X-linked
NLRP2 NLR family, pyrin domain containing 2
NMU neuromedin U
NPTX2 neuronal pentraxin II
NSG1 neuron specific gene family member 1
PBX3 pre-B-cell leukemia homeobox 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PRAME preferentially expressed antigen in melanoma
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RNASE6 ribonuclease, RNase A family, k6
S100A2 S100 calcium binding protein A2
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STON1 stonin 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TMEM259 transmembrane protein 259
TMEM45A transmembrane protein 45A
TSPAN12 tetraspanin 12
TXNIP thioredoxin interacting protein
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
VIM vimentin

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACBD3 acyl-CoA binding domain containing 3
ACSL3 acyl-CoA synthetase long-chain family member 3
AGR2 anterior gradient 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ARPP19 cAMP-regulated phosphoprotein, 19kDa
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BRPF1 bromodomain and PHD finger containing, 1
C14ORF2 chromosome 14 open reading frame 2
C6ORF48 chromosome 6 open reading frame 48
CA12 carbonic anhydrase XII
CCNF cyclin F
CDC25A cell division cycle 25A
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEP350 centrosomal protein 350kDa
CKS2 CDC28 protein kinase regulatory subunit 2
CREBBP CREB binding protein
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF4B eukaryotic translation initiation factor 4B
ELF1 E74-like factor 1 (ets domain transcription factor)
EXOSC4 exosome component 4
FGF13 fibroblast growth factor 13
FKBP11 FK506 binding protein 11, 19 kDa
FXYD3 FXYD domain containing ion transport regulator 3
GABPB1 GA binding protein transcription factor, beta subunit 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GATA3 GATA binding protein 3
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HOMER1 homer scaffolding protein 1
INSIG1 insulin induced gene 1
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KIAA1324 KIAA1324
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KRT7 keratin 7, type II
KYNU kynureninase
LARP4 La ribonucleoprotein domain family, member 4
LDLR low density lipoprotein receptor
LMO2 LIM domain only 2 (rhombotin-like 1)
LRIF1 ligand dependent nuclear receptor interacting factor 1
MAPK6 mitogen-activated protein kinase 6
MED13 mediator complex subunit 13
MYBPC1 myosin binding protein C, slow type
N4BP2L2 NEDD4 binding protein 2-like 2
NCK1 NCK adaptor protein 1
NET1 neuroepithelial cell transforming 1
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
PARP2 poly (ADP-ribose) polymerase 2
PDGFA platelet-derived growth factor alpha polypeptide
PFKP phosphofructokinase, platelet
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLR1D polymerase (RNA) I polypeptide D, 16kDa
RBM34 RNA binding motif protein 34
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RNMT RNA (guanine-7-) methyltransferase
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEC24A SEC24 family member A
SETD5 SET domain containing 5
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SPDEF SAM pointed domain containing ETS transcription factor
SPRED2 sprouty-related, EVH1 domain containing 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBP TATA box binding protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TEX10 testis expressed 10
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLK2 tousled-like kinase 2
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
WAPAL wings apart-like homolog (Drosophila)
WEE1 WEE1 G2 checkpoint kinase
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZCCHC2 zinc finger, CCHC domain containing 2
ZFC3H1 zinc finger, C3H1-type containing
ZMYM2 zinc finger, MYM-type 2