BRD-K79222491_2-morpholino-9-(thiophen-3-yl)-N-((5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)methyl)-9H-purin-6-amine_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-K79222491_2-morpholino-9-(thiophen-3-yl)-N-((5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)methyl)-9H-purin-6-amine_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADD3 adducin 3 (gamma)
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
AOX1 aldehyde oxidase 1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHL1 cell adhesion molecule L1-like
COL6A2 collagen, type VI, alpha 2
CYBA cytochrome b-245, alpha polypeptide
EGR1 early growth response 1
FGFR3 fibroblast growth factor receptor 3
FN1 fibronectin 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOS FBJ murine osteosarcoma viral oncogene homolog
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GSTA1 glutathione S-transferase alpha 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HOXC6 homeobox C6
IER3 immediate early response 3
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
ITM2A integral membrane protein 2A
LAMP5 lysosomal-associated membrane protein family, member 5
LEF1 lymphoid enhancer-binding factor 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LTBP3 latent transforming growth factor beta binding protein 3
MAB21L2 mab-21-like 2 (C. elegans)
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
NEFH neurofilament, heavy polypeptide
NPDC1 neural proliferation, differentiation and control, 1
OLFM4 olfactomedin 4
PCCB propionyl CoA carboxylase, beta polypeptide
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLSCR3 phospholipid scramblase 3
PRDX2 peroxiredoxin 2
RBP1 retinol binding protein 1, cellular
SCG2 secretogranin II
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SOAT1 sterol O-acyltransferase 1
SRPX sushi-repeat containing protein, X-linked
STEAP1 six transmembrane epithelial antigen of the prostate 1
SYT1 synaptotagmin I
TMSB15A thymosin beta 15a
TNNC1 troponin C type 1 (slow)
TUBA1A tubulin, alpha 1a

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
AURKA aurora kinase A
AXIN1 axin 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BMP4 bone morphogenetic protein 4
CANT1 calcium activated nucleotidase 1
CCNF cyclin F
CDC25A cell division cycle 25A
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
INHBB inhibin, beta B
MED13 mediator complex subunit 13
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
NARFL nuclear prelamin A recognition factor-like
NAV2 neuron navigator 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NUP62 nucleoporin 62kDa
PXDC1 PX domain containing 1
RPP38 ribonuclease P/MRP 38kDa subunit
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SUZ12 SUZ12 polycomb repressive complex 2 subunit
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TEX10 testis expressed 10
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM2 transmembrane protein 2
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TRPS1 trichorhinophalangeal syndrome I
TSC22D2 TSC22 domain family, member 2
TXNDC9 thioredoxin domain containing 9
WAC WW domain containing adaptor with coiled-coil
WEE1 WEE1 G2 checkpoint kinase
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
ZYX zyxin