BRD-K79222491_2-morpholino-9-(thiophen-3-yl)-N-((5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)methyl)-9H-purin-6-amine_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

288 genes differentially expressed following the BRD-K79222491_2-morpholino-9-(thiophen-3-yl)-N-((5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)methyl)-9H-purin-6-amine_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACP5 acid phosphatase 5, tartrate resistant
ADD3 adducin 3 (gamma)
ADGRF5 adhesion G protein-coupled receptor F5
ADIRF adipogenesis regulatory factor
AEBP1 AE binding protein 1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMIGO2 adhesion molecule with Ig-like domain 2
ANGPTL2 angiopoietin-like 2
AQP1 aquaporin 1 (Colton blood group)
ASPN asporin
ATF3 activating transcription factor 3
BLNK B-cell linker
BTG2 BTG family, member 2
C3ORF14 chromosome 3 open reading frame 14
CA2 carbonic anhydrase II
CA4 carbonic anhydrase IV
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CD47 CD47 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CETN2 centrin, EF-hand protein, 2
CFB complement factor B
CFH complement factor H
CLC Charcot-Leyden crystal galectin
CLIC5 chloride intracellular channel 5
COL11A1 collagen, type XI, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CRIP2 cysteine-rich protein 2
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
DUSP1 dual specificity phosphatase 1
EGFL6 EGF-like-domain, multiple 6
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR1 early growth response 1
EMP1 epithelial membrane protein 1
EVI2A ecotropic viral integration site 2A
EXPH5 exophilin 5
FLT1 fms-related tyrosine kinase 1
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GPM6A glycoprotein M6A
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HPGDS hematopoietic prostaglandin D synthase
HRSP12 heat-responsive protein 12
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
JUN jun proto-oncogene
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KDR kinase insert domain receptor
KIAA0226L KIAA0226-like
LRRC17 leucine rich repeat containing 17
LTBP1 latent transforming growth factor beta binding protein 1
MB myoglobin
MEIS2 Meis homeobox 2
MYOF myoferlin
NDRG1 N-myc downstream regulated 1
NEBL nebulette
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NMRK1 nicotinamide riboside kinase 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
P3H2 prolyl 3-hydroxylase 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PFKM phosphofructokinase, muscle
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAU plasminogen activator, urokinase
PLVAP plasmalemma vesicle associated protein
PODXL podocalyxin-like
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKCI protein kinase C, iota
PRSS16 protease, serine, 16 (thymus)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
S100A14 S100 calcium binding protein A14
S100A8 S100 calcium binding protein A8
SCGB1D2 secretoglobin, family 1D, member 2
SCN3A sodium channel, voltage gated, type III alpha subunit
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPON1 spondin 1, extracellular matrix protein
STC1 stanniocalcin 1
SULF1 sulfatase 1
TCF21 transcription factor 21
TCF4 transcription factor 4
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TNNT1 troponin T type 1 (skeletal, slow)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN12 tetraspanin 12
TUSC3 tumor suppressor candidate 3
VEGFA vascular endothelial growth factor A
VSIG4 V-set and immunoglobulin domain containing 4
VTCN1 V-set domain containing T cell activation inhibitor 1
ZNF586 zinc finger protein 586
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACBD3 acyl-CoA binding domain containing 3
ADGRG2 adhesion G protein-coupled receptor G2
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMD1 adenosylmethionine decarboxylase 1
ARHGAP12 Rho GTPase activating protein 12
ARID4B AT rich interactive domain 4B (RBP1-like)
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
AURKA aurora kinase A
BAG2 BCL2-associated athanogene 2
BASP1 brain abundant, membrane attached signal protein 1
BLCAP bladder cancer associated protein
BRD3 bromodomain containing 3
BRPF1 bromodomain and PHD finger containing, 1
BUB3 BUB3 mitotic checkpoint protein
C14ORF169 chromosome 14 open reading frame 169
C1S complement component 1, s subcomponent
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDCA4 cell division cycle associated 4
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CENPF centromere protein F, 350/400kDa
CHD1 chromodomain helicase DNA binding protein 1
CHERP calcium homeostasis endoplasmic reticulum protein
CHSY1 chondroitin sulfate synthase 1
CKS2 CDC28 protein kinase regulatory subunit 2
COCH cochlin
COIL coilin
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTR9 CTR9, Paf1/RNA polymerase II complex component
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DFNA5 deafness, autosomal dominant 5
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLG5 discs, large homolog 5 (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EFHD2 EF-hand domain family, member D2
EIF4B eukaryotic translation initiation factor 4B
ELF1 E74-like factor 1 (ets domain transcription factor)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FAM208B family with sequence similarity 208, member B
FASTKD5 FAST kinase domains 5
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
FOXO1 forkhead box O1
FOXO3 forkhead box O3
GABPB1 GA binding protein transcription factor, beta subunit 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GCH1 GTP cyclohydrolase 1
GEMIN4 gem (nuclear organelle) associated protein 4
GNAS GNAS complex locus
GPATCH8 G patch domain containing 8
GRWD1 glutamate-rich WD repeat containing 1
GSPT2 G1 to S phase transition 2
HEXIM1 hexamethylene bis-acetamide inducible 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IQGAP2 IQ motif containing GTPase activating protein 2
IRS2 insulin receptor substrate 2
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
ITGA6 integrin, alpha 6
JMJD6 jumonji domain containing 6
KEAP1 kelch-like ECH-associated protein 1
KIF2C kinesin family member 2C
KLHL21 kelch-like family member 21
KRT17 keratin 17, type I
LRIF1 ligand dependent nuclear receptor interacting factor 1
LSG1 large 60S subunit nuclear export GTPase 1
MAK16 MAK16 homolog (S. cerevisiae)
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MGA MGA, MAX dimerization protein
MMD monocyte to macrophage differentiation-associated
MSH6 mutS homolog 6
MTF2 metal response element binding transcription factor 2
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NCK1 NCK adaptor protein 1
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NKX3-1 NK3 homeobox 1
NRIP1 nuclear receptor interacting protein 1
NUP153 nucleoporin 153kDa
NUP50 nucleoporin 50kDa
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDS5B PDS5 cohesin associated factor B
PDZD8 PDZ domain containing 8
PER2 period circadian clock 2
PHF20 PHD finger protein 20
PHF3 PHD finger protein 3
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
PPIF peptidylprolyl isomerase F
PRKCA protein kinase C, alpha
PRPF4B pre-mRNA processing factor 4B
RAE1 ribonucleic acid export 1
RANBP2 RAN binding protein 2
RBM14 RNA binding motif protein 14
RBM15 RNA binding motif protein 15
RBM39 RNA binding motif protein 39
RLF rearranged L-myc fusion
RNF6 ring finger protein (C3H2C3 type) 6
RNMT RNA (guanine-7-) methyltransferase
RPP38 ribonuclease P/MRP 38kDa subunit
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100P S100 calcium binding protein P
SACS sacsin molecular chaperone
SAMD4A sterile alpha motif domain containing 4A
SCAF8 SR-related CTD-associated factor 8
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFPQ splicing factor proline/glutamine-rich
SIAH2 siah E3 ubiquitin protein ligase 2
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF11 serine/arginine-rich splicing factor 11
STIL SCL/TAL1 interrupting locus
STK17A serine/threonine kinase 17a
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBC1D4 TBC1 domain family, member 4
TBP TATA box binding protein
TBPL1 TBP-like 1
TBX3 T-box 3
TFB2M transcription factor B2, mitochondrial
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM11 transmembrane protein 11
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TPX2 TPX2, microtubule-associated
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TSPYL5 TSPY-like 5
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
USP1 ubiquitin specific peptidase 1
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
WAC WW domain containing adaptor with coiled-coil
WDR82 WD repeat domain 82
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
WTAP Wilms tumor 1 associated protein
XBP1 X-box binding protein 1
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3
ZBTB11 zinc finger and BTB domain containing 11
ZCCHC2 zinc finger, CCHC domain containing 2
ZMYM2 zinc finger, MYM-type 2
ZNF330 zinc finger protein 330