BRD-K79222491_2-morpholino-9-(thiophen-3-yl)-N-((5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)methyl)-9H-purin-6-amine_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

255 genes differentially expressed following the BRD-K79222491_2-morpholino-9-(thiophen-3-yl)-N-((5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)methyl)-9H-purin-6-amine_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
ADGRL2 adhesion G protein-coupled receptor L2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
APOB apolipoprotein B
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BSG basigin (Ok blood group)
C3ORF14 chromosome 3 open reading frame 14
CALD1 caldesmon 1
CD52 CD52 molecule
CD93 CD93 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLCA1 chloride channel accessory 1
CLIC5 chloride intracellular channel 5
COL11A1 collagen, type XI, alpha 1
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CRIP2 cysteine-rich protein 2
CTSZ cathepsin Z
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL2 chemokine (C-X-C motif) ligand 2
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FABP1 fatty acid binding protein 1, liver
FABP4 fatty acid binding protein 4, adipocyte
FGA fibrinogen alpha chain
FGG fibrinogen gamma chain
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FLT1 fms-related tyrosine kinase 1
FOS FBJ murine osteosarcoma viral oncogene homolog
G0S2 G0/G1 switch 2
GAS6 growth arrest-specific 6
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GSN gelsolin
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPG2 heparan sulfate proteoglycan 2
INA internexin neuronal intermediate filament protein, alpha
ISG15 ISG15 ubiquitin-like modifier
ISYNA1 inositol-3-phosphate synthase 1
KIAA0226L KIAA0226-like
KRT20 keratin 20, type I
LGALS4 lectin, galactoside-binding, soluble, 4
LRRC15 leucine rich repeat containing 15
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
MPZL2 myelin protein zero-like 2
MYO1B myosin IB
OLFM4 olfactomedin 4
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PF4 platelet factor 4
PLAT plasminogen activator, tissue
PLS3 plastin 3
PLVAP plasmalemma vesicle associated protein
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PRKCI protein kinase C, iota
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PXDN peroxidasin
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS5 regulator of G-protein signaling 5
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCG2 secretogranin II
SDC2 syndecan 2
SEPT2 septin 2
SERINC3 serine incorporator 3
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SOX11 SRY (sex determining region Y)-box 11
SULF1 sulfatase 1
TCF4 transcription factor 4
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM259 transmembrane protein 259
TUSC3 tumor suppressor candidate 3
TWIST1 twist family bHLH transcription factor 1
XIST X inactive specific transcript (non-protein coding)
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AFF1 AF4/FMR2 family, member 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ARF6 ADP-ribosylation factor 6
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARID4B AT rich interactive domain 4B (RBP1-like)
ARMCX6 armadillo repeat containing, X-linked 6
ASXL2 additional sex combs like transcriptional regulator 2
AURKA aurora kinase A
BIK BCL2-interacting killer (apoptosis-inducing)
BLM Bloom syndrome, RecQ helicase-like
BLMH bleomycin hydrolase
BST2 bone marrow stromal cell antigen 2
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHERP calcium homeostasis endoplasmic reticulum protein
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CNOT4 CCR4-NOT transcription complex, subunit 4
COG2 component of oligomeric golgi complex 2
COIL coilin
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
DBF4 DBF4 zinc finger
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNMBP dynamin binding protein
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EIF4B eukaryotic translation initiation factor 4B
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FADD Fas (TNFRSF6)-associated via death domain
FAM222B family with sequence similarity 222, member B
FBXO11 F-box protein 11
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GDF15 growth differentiation factor 15
GEMIN4 gem (nuclear organelle) associated protein 4
GLDC glycine dehydrogenase (decarboxylating)
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOSR1 golgi SNAP receptor complex member 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRWD1 glutamate-rich WD repeat containing 1
GSPT2 G1 to S phase transition 2
GTPBP8 GTP-binding protein 8 (putative)
HSPA14 heat shock 70kDa protein 14
HSPA8 heat shock 70kDa protein 8
INPP1 inositol polyphosphate-1-phosphatase
IRS2 insulin receptor substrate 2
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE1 jade family PHD finger 1
JADE2 jade family PHD finger 2
JARID2 jumonji, AT rich interactive domain 2
KDM2A lysine (K)-specific demethylase 2A
KEAP1 kelch-like ECH-associated protein 1
KIF14 kinesin family member 14
KIF2C kinesin family member 2C
KYNU kynureninase
LDHB lactate dehydrogenase B
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRRC16A leucine rich repeat containing 16A
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MED1 mediator complex subunit 1
MID1IP1 MID1 interacting protein 1
MKI67 marker of proliferation Ki-67
MRFAP1L1 Morf4 family associated protein 1-like 1
MRPS30 mitochondrial ribosomal protein S30
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV3 neuron navigator 3
NCALD neurocalcin delta
NKX3-1 NK3 homeobox 1
NOP56 NOP56 ribonucleoprotein
NOTCH2 notch 2
NOTCH2NL notch 2 N-terminal like
NPAT nuclear protein, ataxia-telangiectasia locus
NRN1 neuritin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PFKP phosphofructokinase, platelet
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PLK4 polo-like kinase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PROM1 prominin 1
PRPF4 pre-mRNA processing factor 4
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB14 RAB14, member RAS oncogene family
RAE1 ribonucleic acid export 1
RANBP2 RAN binding protein 2
RBM15 RNA binding motif protein 15
RGS2 regulator of G-protein signaling 2
RNF111 ring finger protein 111
RNF219 ring finger protein 219
RNMT RNA (guanine-7-) methyltransferase
RPL36AL ribosomal protein L36a-like
RPP38 ribonuclease P/MRP 38kDa subunit
RPS11 ribosomal protein S11
RRP1B ribosomal RNA processing 1B
RUNX3 runt-related transcription factor 3
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SACS sacsin molecular chaperone
SART3 squamous cell carcinoma antigen recognized by T cells 3
SAV1 salvador family WW domain containing protein 1
SCAF8 SR-related CTD-associated factor 8
SECISBP2L SECIS binding protein 2-like
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SETD5 SET domain containing 5
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SON SON DNA binding protein
SOX9 SRY (sex determining region Y)-box 9
STIL SCL/TAL1 interrupting locus
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBC1D4 TBC1 domain family, member 4
TCERG1 transcription elongation regulator 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNPO1 transportin 1
TOB2 transducer of ERBB2, 2
TPX2 TPX2, microtubule-associated
TRIM32 tripartite motif containing 32
TSC22D1 TSC22 domain family, member 1
TSC22D2 TSC22 domain family, member 2
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBAP2 ubiquitin associated protein 2
USP1 ubiquitin specific peptidase 1
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VEZF1 vascular endothelial zinc finger 1
WAC WW domain containing adaptor with coiled-coil
WAPAL wings apart-like homolog (Drosophila)
WDR82 WD repeat domain 82
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBTB18 zinc finger and BTB domain containing 18
ZBTB24 zinc finger and BTB domain containing 24
ZC3H4 zinc finger CCCH-type containing 4
ZCCHC2 zinc finger, CCHC domain containing 2
ZCCHC8 zinc finger, CCHC domain containing 8
ZNF189 zinc finger protein 189
ZNF22 zinc finger protein 22
ZNF330 zinc finger protein 330
ZNF451 zinc finger protein 451