BRD-K79222491_2-morpholino-9-(thiophen-3-yl)-N-((5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)methyl)-9H-purin-6-amine_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

318 genes differentially expressed following the BRD-K79222491_2-morpholino-9-(thiophen-3-yl)-N-((5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)methyl)-9H-purin-6-amine_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRF5 adhesion G protein-coupled receptor F5
AEBP1 AE binding protein 1
AIDA axin interactor, dorsalization associated
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALOX5 arachidonate 5-lipoxygenase
ASNS asparagine synthetase (glutamine-hydrolyzing)
BLNK B-cell linker
BPHL biphenyl hydrolase-like (serine hydrolase)
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CAV2 caveolin 2
CCL2 chemokine (C-C motif) ligand 2
CD47 CD47 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CKB creatine kinase, brain
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CPM carboxypeptidase M
CRABP2 cellular retinoic acid binding protein 2
DCN decorin
DHCR24 24-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FGFR3 fibroblast growth factor receptor 3
FLT1 fms-related tyrosine kinase 1
GDE1 glycerophosphodiester phosphodiesterase 1
GPM6A glycoprotein M6A
GPM6B glycoprotein M6B
GUSBP3 glucuronidase, beta pseudogene 3
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IER3 immediate early response 3
IFITM3 interferon induced transmembrane protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
INHBB inhibin, beta B
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KCNK3 potassium channel, two pore domain subfamily K, member 3
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIAA0226L KIAA0226-like
KRT8 keratin 8, type II
LTB lymphotoxin beta (TNF superfamily, member 3)
LTBP1 latent transforming growth factor beta binding protein 1
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MED13L mediator complex subunit 13-like
MMP9 matrix metallopeptidase 9
MSMB microseminoprotein, beta-
MYO1B myosin IB
NEBL nebulette
NPIPB3 nuclear pore complex interacting protein family, member B3
NRP1 neuropilin 1
NUPR1 nuclear protein, transcriptional regulator, 1
ORM1 orosomucoid 1
PAWR PRKC, apoptosis, WT1, regulator
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PON2 paraoxonase 2
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
RPS4Y1 ribosomal protein S4, Y-linked 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC1 syndecan 1
SEPP1 selenoprotein P, plasma, 1
SEPT2 septin 2
SFTPB surfactant protein B
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNX10 sorting nexin 10
SOX11 SRY (sex determining region Y)-box 11
SPON2 spondin 2, extracellular matrix protein
SST somatostatin
STC1 stanniocalcin 1
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TBX2 T-box 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPD52L1 tumor protein D52-like 1
TPSAB1 tryptase alpha/beta 1
TUSC3 tumor suppressor candidate 3
VSIG4 V-set and immunoglobulin domain containing 4

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACBD3 acyl-CoA binding domain containing 3
ADM adrenomedullin
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AFF1 AF4/FMR2 family, member 1
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL4A ADP-ribosylation factor-like 4A
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BCL10 B-cell CLL/lymphoma 10
BCOR BCL6 corepressor
BLCAP bladder cancer associated protein
C14ORF169 chromosome 14 open reading frame 169
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNE1 cyclin E1
CCNF cyclin F
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDR2 cerebellar degeneration-related protein 2, 62kDa
CENPA centromere protein A
CEP76 centrosomal protein 76kDa
CHERP calcium homeostasis endoplasmic reticulum protein
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKAP2 cytoskeleton associated protein 2
CKS2 CDC28 protein kinase regulatory subunit 2
COIL coilin
CREBBP CREB binding protein
CRY1 cryptochrome circadian clock 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CYTH1 cytohesin 1
CYTL1 cytokine-like 1
DBF4 DBF4 zinc finger
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DUSP10 dual specificity phosphatase 10
DUSP4 dual specificity phosphatase 4
DUSP7 dual specificity phosphatase 7
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EED embryonic ectoderm development
EFHD2 EF-hand domain family, member D2
EHD1 EH-domain containing 1
ELF1 E74-like factor 1 (ets domain transcription factor)
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ELMO1 engulfment and cell motility 1
EXO1 exonuclease 1
FASTKD5 FAST kinase domains 5
FBXO34 F-box protein 34
FBXO5 F-box protein 5
FEM1B fem-1 homolog b (C. elegans)
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
FOXO3 forkhead box O3
GAS1 growth arrest-specific 1
GATA3 GATA binding protein 3
GGNBP2 gametogenetin binding protein 2
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GOLGA8A golgin A8 family, member A
GSPT2 G1 to S phase transition 2
GTF2B general transcription factor IIB
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa
HJURP Holliday junction recognition protein
HMOX1 heme oxygenase 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HOMER1 homer scaffolding protein 1
HOXA5 homeobox A5
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL6ST interleukin 6 signal transducer
ING3 inhibitor of growth family, member 3
INTS6 integrator complex subunit 6
IRS2 insulin receptor substrate 2
JADE1 jade family PHD finger 1
JMJD6 jumonji domain containing 6
KAT6A K(lysine) acetyltransferase 6A
KAT7 K(lysine) acetyltransferase 7
KDM2A lysine (K)-specific demethylase 2A
KDM5B lysine (K)-specific demethylase 5B
KEAP1 kelch-like ECH-associated protein 1
KIF23 kinesin family member 23
KIF2A kinesin heavy chain member 2A
KIN Kin17 DNA and RNA binding protein
KLK10 kallikrein-related peptidase 10
KRT14 keratin 14, type I
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK6 mitogen-activated protein kinase 6
MEOX1 mesenchyme homeobox 1
MRPS30 mitochondrial ribosomal protein S30
MSH6 mutS homolog 6
MTF2 metal response element binding transcription factor 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAV3 neuron navigator 3
NCK1 NCK adaptor protein 1
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NGDN neuroguidin, EIF4E binding protein
NOP56 NOP56 ribonucleoprotein
NPAT nuclear protein, ataxia-telangiectasia locus
NRBF2 nuclear receptor binding factor 2
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP50 nucleoporin 50kDa
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
OSER1 oxidative stress responsive serine-rich 1
PANK2 pantothenate kinase 2
PARP2 poly (ADP-ribose) polymerase 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PAX8 paired box 8
PDS5B PDS5 cohesin associated factor B
PFKP phosphofructokinase, platelet
PHF20 PHD finger protein 20
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAGL2 pleiomorphic adenoma gene-like 2
PLK1 polo-like kinase 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPIG peptidylprolyl isomerase G (cyclophilin G)
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PROM1 prominin 1
PRPF4 pre-mRNA processing factor 4
PTX3 pentraxin 3, long
RAB14 RAB14, member RAS oncogene family
RAD9A RAD9 homolog A (S. pombe)
RANBP2 RAN binding protein 2
RANBP6 RAN binding protein 6
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RBM15 RNA binding motif protein 15
RBM7 RNA binding motif protein 7
REST RE1-silencing transcription factor
RNF111 ring finger protein 111
RNF219 ring finger protein 219
RNMT RNA (guanine-7-) methyltransferase
RPL36 ribosomal protein L36
RPL36AL ribosomal protein L36a-like
RPP38 ribonuclease P/MRP 38kDa subunit
RRP1B ribosomal RNA processing 1B
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RUNX3 runt-related transcription factor 3
RYBP RING1 and YY1 binding protein
SACS sacsin molecular chaperone
SAP30 Sin3A-associated protein, 30kDa
SAV1 salvador family WW domain containing protein 1
SCAF8 SR-related CTD-associated factor 8
SEC24A SEC24 family member A
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERTAD2 SERTA domain containing 2
SFRP1 secreted frizzled-related protein 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SNX11 sorting nexin 11
SOX9 SRY (sex determining region Y)-box 9
SPRR1A small proline-rich protein 1A
SPRY2 sprouty homolog 2 (Drosophila)
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
STIL SCL/TAL1 interrupting locus
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNJ2 synaptojanin 2
TBC1D4 TBC1 domain family, member 4
TBP TATA box binding protein
TBPL1 TBP-like 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TEX10 testis expressed 10
TEX30 testis expressed 30
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TICAM1 toll-like receptor adaptor molecule 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM11 transmembrane protein 11
TMX4 thioredoxin-related transmembrane protein 4
TNPO1 transportin 1
TP53BP2 tumor protein p53 binding protein 2
TRIM32 tripartite motif containing 32
TSC22D2 TSC22 domain family, member 2
TSPYL5 TSPY-like 5
TUFT1 tuftelin 1
UBE2C ubiquitin-conjugating enzyme E2C
UGCG UDP-glucose ceramide glucosyltransferase
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
WAC WW domain containing adaptor with coiled-coil
WAPAL wings apart-like homolog (Drosophila)
WDR37 WD repeat domain 37
WDR43 WD repeat domain 43
WDR82 WD repeat domain 82
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
XBP1 X-box binding protein 1
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3
ZBTB1 zinc finger and BTB domain containing 1
ZBTB11 zinc finger and BTB domain containing 11
ZBTB18 zinc finger and BTB domain containing 18
ZC3H13 zinc finger CCCH-type containing 13
ZCCHC2 zinc finger, CCHC domain containing 2
ZCCHC8 zinc finger, CCHC domain containing 8
ZMYM2 zinc finger, MYM-type 2
ZNF22 zinc finger protein 22
ZNF267 zinc finger protein 267
ZNF330 zinc finger protein 330