BRD-K79222491_2-morpholino-9-(thiophen-3-yl)-N-((5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)methyl)-9H-purin-6-amine_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

315 genes differentially expressed following the BRD-K79222491_2-morpholino-9-(thiophen-3-yl)-N-((5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)methyl)-9H-purin-6-amine_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACOT7 acyl-CoA thioesterase 7
ACTA2 actin, alpha 2, smooth muscle, aorta
ADAM9 ADAM metallopeptidase domain 9
ADGRA2 adhesion G protein-coupled receptor A2
ADIRF adipogenesis regulatory factor
AEBP1 AE binding protein 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANPEP alanyl (membrane) aminopeptidase
AQP1 aquaporin 1 (Colton blood group)
AQP9 aquaporin 9
ARG2 arginase 2
ASPN asporin
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BLNK B-cell linker
BTG2 BTG family, member 2
C3ORF14 chromosome 3 open reading frame 14
C9ORF16 chromosome 9 open reading frame 16
CA2 carbonic anhydrase II
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CD14 CD14 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD47 CD47 molecule
CD9 CD9 molecule
CD93 CD93 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CFB complement factor B
CFD complement factor D (adipsin)
CLDN3 claudin 3
COL10A1 collagen, type X, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CRIP2 cysteine-rich protein 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DHCR24 24-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYD dihydropyrimidine dehydrogenase
DPYSL3 dihydropyrimidinase-like 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ERP44 endoplasmic reticulum protein 44
FILIP1L filamin A interacting protein 1-like
FLT1 fms-related tyrosine kinase 1
G0S2 G0/G1 switch 2
GM2A GM2 ganglioside activator
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPM6A glycoprotein M6A
HES1 hes family bHLH transcription factor 1
HIST1H2BD histone cluster 1, H2bd
HOXB2 homeobox B2
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IER3 immediate early response 3
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
INHBA inhibin, beta A
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
KIAA0226L KIAA0226-like
KRT19 keratin 19, type I
LAMP2 lysosomal-associated membrane protein 2
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3 lectin, galactoside-binding, soluble, 3
LRRC15 leucine rich repeat containing 15
LRRC17 leucine rich repeat containing 17
LUM lumican
MAGT1 magnesium transporter 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MATN2 matrilin 2
MMP9 matrix metallopeptidase 9
MSMB microseminoprotein, beta-
MSRA methionine sulfoxide reductase A
MXRA5 matrix-remodelling associated 5
NEBL nebulette
NEFH neurofilament, heavy polypeptide
OLFM4 olfactomedin 4
ORM1 orosomucoid 1
PBX3 pre-B-cell leukemia homeobox 3
PCP4 Purkinje cell protein 4
PLAU plasminogen activator, urokinase
PLBD1 phospholipase B domain containing 1
PLN phospholamban
PLVAP plasmalemma vesicle associated protein
POSTN periostin, osteoblast specific factor
PROSC proline synthetase co-transcribed homolog (bacterial)
PRR15L proline rich 15-like
PSPH phosphoserine phosphatase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PVALB parvalbumin
PYCARD PYD and CARD domain containing
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
SCG2 secretogranin II
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SMYD3 SET and MYND domain containing 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SULF1 sulfatase 1
TCF4 transcription factor 4
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TPM2 tropomyosin 2 (beta)
TUBA1A tubulin, alpha 1a
VTCN1 V-set domain containing T cell activation inhibitor 1
WLS wntless Wnt ligand secretion mediator

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADNP activity-dependent neuroprotector homeobox
ADNP2 ADNP homeobox 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMD1 adenosylmethionine decarboxylase 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID1A AT rich interactive domain 1A (SWI-like)
ASXL2 additional sex combs like transcriptional regulator 2
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BASP1 brain abundant, membrane attached signal protein 1
BLCAP bladder cancer associated protein
BRPF1 bromodomain and PHD finger containing, 1
CA12 carbonic anhydrase XII
CASC3 cancer susceptibility candidate 3
CCDC59 coiled-coil domain containing 59
CCNA2 cyclin A2
CD3EAP CD3e molecule, epsilon associated protein
CDC14B cell division cycle 14B
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CHERP calcium homeostasis endoplasmic reticulum protein
CHPT1 choline phosphotransferase 1
CHSY1 chondroitin sulfate synthase 1
COIL coilin
DAPK1 death-associated protein kinase 1
DBF4 DBF4 zinc finger
DDIT4 DNA-damage-inducible transcript 4
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EED embryonic ectoderm development
EFHD2 EF-hand domain family, member D2
EIF4B eukaryotic translation initiation factor 4B
EIF5 eukaryotic translation initiation factor 5
FAM102A family with sequence similarity 102, member A
FAM208B family with sequence similarity 208, member B
FAM46C family with sequence similarity 46, member C
FASTKD5 FAST kinase domains 5
FGF13 fibroblast growth factor 13
FOSL1 FOS-like antigen 1
FOXD1 forkhead box D1
FOXJ3 forkhead box J3
GABPB1 GA binding protein transcription factor, beta subunit 1
GGNBP2 gametogenetin binding protein 2
GLIPR1 GLI pathogenesis-related 1
GOLPH3L golgi phosphoprotein 3-like
GOSR1 golgi SNAP receptor complex member 1
GRWD1 glutamate-rich WD repeat containing 1
HJURP Holliday junction recognition protein
HMOX1 heme oxygenase 1
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IGFBP4 insulin-like growth factor binding protein 4
ILF3 interleukin enhancer binding factor 3, 90kDa
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE1 jade family PHD finger 1
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KANSL2 KAT8 regulatory NSL complex subunit 2
KDM2A lysine (K)-specific demethylase 2A
KDM5B lysine (K)-specific demethylase 5B
KEAP1 kelch-like ECH-associated protein 1
KLF4 Kruppel-like factor 4 (gut)
KRT7 keratin 7, type II
KYNU kynureninase
LRIF1 ligand dependent nuclear receptor interacting factor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MED1 mediator complex subunit 1
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
MPRIP myosin phosphatase Rho interacting protein
MRPS30 mitochondrial ribosomal protein S30
MSH6 mutS homolog 6
MSL1 male-specific lethal 1 homolog (Drosophila)
MSL2 male-specific lethal 2 homolog (Drosophila)
MTF2 metal response element binding transcription factor 2
MYO10 myosin X
NET1 neuroepithelial cell transforming 1
NGDN neuroguidin, EIF4E binding protein
NKX3-1 NK3 homeobox 1
NOL11 nucleolar protein 11
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NPAS2 neuronal PAS domain protein 2
NRIP1 nuclear receptor interacting protein 1
NUP50 nucleoporin 50kDa
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PLAGL2 pleiomorphic adenoma gene-like 2
PLK1 polo-like kinase 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
RAD9A RAD9 homolog A (S. pombe)
RAE1 ribonucleic acid export 1
RANBP2 RAN binding protein 2
RAP2B RAP2B, member of RAS oncogene family
RBM14 RNA binding motif protein 14
RBM15 RNA binding motif protein 15
RBM39 RNA binding motif protein 39
RHOF ras homolog family member F (in filopodia)
RNF114 ring finger protein 114
RNF139 ring finger protein 139
RNF4 ring finger protein 4
RNMT RNA (guanine-7-) methyltransferase
RNPS1 RNA binding protein S1, serine-rich domain
RPL36AL ribosomal protein L36a-like
RPS11 ribosomal protein S11
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSRC2 arginine/serine-rich coiled-coil 2
RUNX3 runt-related transcription factor 3
SACS sacsin molecular chaperone
SCAF8 SR-related CTD-associated factor 8
SERTAD2 SERTA domain containing 2
SETD1B SET domain containing 1B
SETD5 SET domain containing 5
SIK1 salt-inducible kinase 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMAD3 SMAD family member 3
SON SON DNA binding protein
SPATA2 spermatogenesis associated 2
SPRR1A small proline-rich protein 1A
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
TBP TATA box binding protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TGIF1 TGFB-induced factor homeobox 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLE3 transducin-like enhancer of split 3
TMEM11 transmembrane protein 11
TNPO1 transportin 1
TP53BP2 tumor protein p53 binding protein 2
TRIAP1 TP53 regulated inhibitor of apoptosis 1
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TSPYL5 TSPY-like 5
TXLNA taxilin alpha
UBAP2L ubiquitin associated protein 2-like
UGCG UDP-glucose ceramide glucosyltransferase
UPK1B uroplakin 1B
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
USP6NL USP6 N-terminal like
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
WAC WW domain containing adaptor with coiled-coil
WDR6 WD repeat domain 6
WDR82 WD repeat domain 82
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
WTAP Wilms tumor 1 associated protein
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
YTHDC1 YTH domain containing 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
ZBTB1 zinc finger and BTB domain containing 1
ZCCHC8 zinc finger, CCHC domain containing 8
ZNF146 zinc finger protein 146
ZNF207 zinc finger protein 207