BRD-K79222491_2-morpholino-9-(thiophen-3-yl)-N-((5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)methyl)-9H-purin-6-amine_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

247 genes differentially expressed following the BRD-K79222491_2-morpholino-9-(thiophen-3-yl)-N-((5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)methyl)-9H-purin-6-amine_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADD3 adducin 3 (gamma)
AIDA axin interactor, dorsalization associated
ALB albumin
ALDOB aldolase B, fructose-bisphosphate
ANGPTL2 angiopoietin-like 2
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ARMCX1 armadillo repeat containing, X-linked 1
ASPN asporin
ATF3 activating transcription factor 3
ATM ATM serine/threonine kinase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX4 brain expressed, X-linked 4
C3AR1 complement component 3a receptor 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CCL4 chemokine (C-C motif) ligand 4
CD24 CD24 molecule
CD52 CD52 molecule
CLC Charcot-Leyden crystal galectin
CLCA4 chloride channel accessory 4
CLEC10A C-type lectin domain family 10, member A
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CRISP3 cysteine-rich secretory protein 3
CTSK cathepsin K
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CYBB cytochrome b-245, beta polypeptide
DIAPH2 diaphanous-related formin 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
ECM1 extracellular matrix protein 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ERBB4 erb-b2 receptor tyrosine kinase 4
ESRP1 epithelial splicing regulatory protein 1
EXPH5 exophilin 5
FGL2 fibrinogen-like 2
FHL1 four and a half LIM domains 1
FHOD3 formin homology 2 domain containing 3
FILIP1L filamin A interacting protein 1-like
G0S2 G0/G1 switch 2
GBP1 guanylate binding protein 1, interferon-inducible
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGN4 high mobility group nucleosomal binding domain 4
IDO1 indoleamine 2,3-dioxygenase 1
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IGSF6 immunoglobulin superfamily, member 6
IL7R interleukin 7 receptor
INSM1 insulinoma-associated 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KRT19 keratin 19, type I
LDOC1 leucine zipper, down-regulated in cancer 1
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MT1E metallothionein 1E
MXRA5 matrix-remodelling associated 5
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NEBL nebulette
NPIPB3 nuclear pore complex interacting protein family, member B3
NR4A2 nuclear receptor subfamily 4, group A, member 2
OBSL1 obscurin-like 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE4DIP phosphodiesterase 4D interacting protein
PDLIM3 PDZ and LIM domain 3
PKP2 plakophilin 2
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
POSTN periostin, osteoblast specific factor
PRTN3 proteinase 3
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PYCARD PYD and CARD domain containing
RAB25 RAB25, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SOCS2 suppressor of cytokine signaling 2
SOX11 SRY (sex determining region Y)-box 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
SPINT1 serine peptidase inhibitor, Kunitz type 1
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STC1 stanniocalcin 1
STON1 stonin 1
SULF1 sulfatase 1
TCF4 transcription factor 4
TF transferrin
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS1 thrombospondin 1
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM30B transmembrane protein 30B
TMSB15A thymosin beta 15a
TPBG trophoblast glycoprotein
TRPS1 trichorhinophalangeal syndrome I
TYROBP TYRO protein tyrosine kinase binding protein
VGLL1 vestigial-like family member 1
VNN1 vanin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
YME1L1 YME1-like 1 ATPase
ZNF331 zinc finger protein 331
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AATF apoptosis antagonizing transcription factor
ACACA acetyl-CoA carboxylase alpha
ACOT9 acyl-CoA thioesterase 9
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMD1 adenosylmethionine decarboxylase 1
AQP3 aquaporin 3 (Gill blood group)
ARMCX6 armadillo repeat containing, X-linked 6
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
BIN1 bridging integrator 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCNB2 cyclin B2
CD58 CD58 molecule
CDC25B cell division cycle 25B
CENPA centromere protein A
CHERP calcium homeostasis endoplasmic reticulum protein
CHPT1 choline phosphotransferase 1
CIT citron rho-interacting serine/threonine kinase
CLTA clathrin, light chain A
CLTC clathrin, heavy chain (Hc)
CSK c-src tyrosine kinase
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL5 chemokine (C-X-C motif) ligand 5
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCK deoxycytidine kinase
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DUSP4 dual specificity phosphatase 4
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FSCN1 fascin actin-bundling protein 1
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GLOD4 glyoxalase domain containing 4
GRWD1 glutamate-rich WD repeat containing 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HN1 hematological and neurological expressed 1
HOXB7 homeobox B7
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KDM5D lysine (K)-specific demethylase 5D
KRT10 keratin 10, type I
LAMB1 laminin, beta 1
LASP1 LIM and SH3 protein 1
LBR lamin B receptor
LRRC59 leucine rich repeat containing 59
MAGED1 melanoma antigen family D1
MALL mal, T-cell differentiation protein-like
MAPK6 mitogen-activated protein kinase 6
MED24 mediator complex subunit 24
MELK maternal embryonic leucine zipper kinase
MID1IP1 MID1 interacting protein 1
MRPS30 mitochondrial ribosomal protein S30
MTUS1 microtubule associated tumor suppressor 1
MYO1E myosin IE
NFIB nuclear factor I/B
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PHB prohibitin
PIR pirin (iron-binding nuclear protein)
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PMP22 peripheral myelin protein 22
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKCA protein kinase C, alpha
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PTGES prostaglandin E synthase
PUF60 poly-U binding splicing factor 60KDa
PWP1 PWP1 homolog (S. cerevisiae)
RAE1 ribonucleic acid export 1
RBM14 RNA binding motif protein 14
RFC2 replication factor C (activator 1) 2, 40kDa
RHOB ras homolog family member B
RPL36AL ribosomal protein L36a-like
RPL37A ribosomal protein L37a
S100P S100 calcium binding protein P
SEH1L SEH1-like (S. cerevisiae)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMS spermine synthase
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SUB1 SUB1 homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TARS threonyl-tRNA synthetase
TBL1X transducin (beta)-like 1X-linked
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM5 transmembrane protein 5
TMEM97 transmembrane protein 97
TMPO thymopoietin
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIAP1 TP53 regulated inhibitor of apoptosis 1
TSKU tsukushi, small leucine rich proteoglycan
TXLNA taxilin alpha
UBAP2 ubiquitin associated protein 2
USP22 ubiquitin specific peptidase 22
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
VCP valosin containing protein