BRD-K79222491_2-morpholino-9-(thiophen-3-yl)-N-((5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)methyl)-9H-purin-6-amine_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

161 genes differentially expressed following the BRD-K79222491_2-morpholino-9-(thiophen-3-yl)-N-((5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)methyl)-9H-purin-6-amine_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
AEBP1 AE binding protein 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AQP9 aquaporin 9
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BTG2 BTG family, member 2
C3 complement component 3
C6ORF62 chromosome 6 open reading frame 62
C7 complement component 7
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCL2 chemokine (C-C motif) ligand 2
CCL4 chemokine (C-C motif) ligand 4
CD24 CD24 molecule
CD52 CD52 molecule
CD9 CD9 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CFB complement factor B
CFD complement factor D (adipsin)
DCN decorin
DEFA4 defensin, alpha 4, corticostatin
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EXPH5 exophilin 5
FBLN1 fibulin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
G0S2 G0/G1 switch 2
GADD45B growth arrest and DNA-damage-inducible, beta
GPM6B glycoprotein M6B
HBB hemoglobin, beta
HIST1H1C histone cluster 1, H1c
HIST2H2BE histone cluster 2, H2be
HMGN4 high mobility group nucleosomal binding domain 4
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
ISG15 ISG15 ubiquitin-like modifier
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KIAA0226L KIAA0226-like
KLF2 Kruppel-like factor 2
KRT19 keratin 19, type I
KRT23 keratin 23, type I
L1CAM L1 cell adhesion molecule
LCN2 lipocalin 2
LGALS3 lectin, galactoside-binding, soluble, 3
LTBP1 latent transforming growth factor beta binding protein 1
LXN latexin
MAN1A1 mannosidase, alpha, class 1A, member 1
METTL7A methyltransferase like 7A
MMP9 matrix metallopeptidase 9
MN1 meningioma (disrupted in balanced translocation) 1
MOXD1 monooxygenase, DBH-like 1
MPO myeloperoxidase
MT1M metallothionein 1M
MYC v-myc avian myelocytomatosis viral oncogene homolog
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OLFM4 olfactomedin 4
ORM1 orosomucoid 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PYCARD PYD and CARD domain containing
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS2 regulator of G-protein signaling 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERINC3 serine incorporator 3
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SOX4 SRY (sex determining region Y)-box 4
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TCF21 transcription factor 21
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
THBS2 thrombospondin 2
TMC6 transmembrane channel-like 6
TMEM14B transmembrane protein 14B
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIM2 tripartite motif containing 2
TTC3 tetratricopeptide repeat domain 3
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC1 WAP four-disulfide core domain 1
ZFP36 ZFP36 ring finger protein
ZFPM2 zinc finger protein, FOG family member 2
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
CCNA2 cyclin A2
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CHERP calcium homeostasis endoplasmic reticulum protein
CRK v-crk avian sarcoma virus CT10 oncogene homolog
DUSP14 dual specificity phosphatase 14
DUSP4 dual specificity phosphatase 4
EED embryonic ectoderm development
EXOSC4 exosome component 4
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FAM13A family with sequence similarity 13, member A
FCGBP Fc fragment of IgG binding protein
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
GRWD1 glutamate-rich WD repeat containing 1
HOXC6 homeobox C6
HSPA14 heat shock 70kDa protein 14
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JMJD6 jumonji domain containing 6
KDM2A lysine (K)-specific demethylase 2A
KEAP1 kelch-like ECH-associated protein 1
MAPK6 mitogen-activated protein kinase 6
MGLL monoglyceride lipase
NET1 neuroepithelial cell transforming 1
NRG1 neuregulin 1
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NUPL1 nucleoporin like 1
PDHX pyruvate dehydrogenase complex, component X
PPIF peptidylprolyl isomerase F
PRKCD protein kinase C, delta
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAE1 ribonucleic acid export 1
RBPMS RNA binding protein with multiple splicing
RFC2 replication factor C (activator 1) 2, 40kDa
RNMT RNA (guanine-7-) methyltransferase
RUNX3 runt-related transcription factor 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TBP TATA box binding protein
TBPL1 TBP-like 1
TFB2M transcription factor B2, mitochondrial
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNPO1 transportin 1
WIPF2 WAS/WASL interacting protein family, member 2
ZMYM2 zinc finger, MYM-type 2