BRD-K79090631_CGP-60474_SKBR3_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

243 genes differentially expressed following the BRD-K79090631_CGP-60474_SKBR3_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADA adenosine deaminase
ADRB2 adrenoceptor beta 2, surface
AGR2 anterior gradient 2
AIF1 allograft inflammatory factor 1
AK4 adenylate kinase 4
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
APLP2 amyloid beta (A4) precursor-like protein 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BCHE butyrylcholinesterase
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BPHL biphenyl hydrolase-like (serine hydrolase)
BTN3A2 butyrophilin, subfamily 3, member A2
CD47 CD47 molecule
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CERS6 ceramide synthase 6
CHRDL1 chordin-like 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC2B C-type lectin domain family 2, member B
COL3A1 collagen, type III, alpha 1
COLEC12 collectin sub-family member 12
CTTN cortactin
CUX1 cut-like homeobox 1
CYCS cytochrome c, somatic
EID1 EP300 interacting inhibitor of differentiation 1
EIF5A eukaryotic translation initiation factor 5A
FAM50A family with sequence similarity 50, member A
FAS Fas cell surface death receptor
FHL1 four and a half LIM domains 1
FLNA filamin A, alpha
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GLB1L2 galactosidase, beta 1-like 2
GMDS GDP-mannose 4,6-dehydratase
GOLM1 golgi membrane protein 1
GPC4 glypican 4
GPX3 glutathione peroxidase 3
GRIA2 glutamate receptor, ionotropic, AMPA 2
HIP1 huntingtin interacting protein 1
HLA-C major histocompatibility complex, class I, C
HLA-G major histocompatibility complex, class I, G
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
IDO1 indoleamine 2,3-dioxygenase 1
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IFT57 intraflagellar transport 57
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LAGE3 L antigen family, member 3
LOC100505650 uncharacterized LOC100505650
MAB21L2 mab-21-like 2 (C. elegans)
MAOA monoamine oxidase A
MEF2C myocyte enhancer factor 2C
MET MET proto-oncogene, receptor tyrosine kinase
MOXD1 monooxygenase, DBH-like 1
MPDZ multiple PDZ domain protein
MXRA5 matrix-remodelling associated 5
MXRA7 matrix-remodelling associated 7
MYO1B myosin IB
NEBL nebulette
NMU neuromedin U
NQO2 NAD(P)H dehydrogenase, quinone 2
NTS neurotensin
PLAGL1 pleiomorphic adenoma gene-like 1
PRAME preferentially expressed antigen in melanoma
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKCB protein kinase C, beta
PRKCZ protein kinase C, zeta
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PYCARD PYD and CARD domain containing
RELN reelin
RGCC regulator of cell cycle
RRAGD Ras-related GTP binding D
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPATA20 spermatogenesis associated 20
SRPX sushi-repeat containing protein, X-linked
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFPI2 tissue factor pathway inhibitor 2
THBS2 thrombospondin 2
THBS4 thrombospondin 4
TMEM47 transmembrane protein 47
TNNC1 troponin C type 1 (slow)
TOM1L1 target of myb1 (chicken)-like 1
TPD52L1 tumor protein D52-like 1
TSPAN13 tetraspanin 13
TUSC3 tumor suppressor candidate 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGP2 UDP-glucose pyrophosphorylase 2
VIM vimentin
VWA5A von Willebrand factor A domain containing 5A
WFDC2 WAP four-disulfide core domain 2
WIF1 WNT inhibitory factor 1
WWTR1 WW domain containing transcription regulator 1
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AHNAK AHNAK nucleoprotein
AHR aryl hydrocarbon receptor
AKAP1 A kinase (PRKA) anchor protein 1
ASCL1 achaete-scute family bHLH transcription factor 1
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BCL10 B-cell CLL/lymphoma 10
BLCAP bladder cancer associated protein
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNF cyclin F
CCR7 chemokine (C-C motif) receptor 7
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHIC2 cysteine-rich hydrophobic domain 2
COL15A1 collagen, type XV, alpha 1
COL1A1 collagen, type I, alpha 1
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP7 dual specificity phosphatase 7
EFNA1 ephrin-A1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM46A family with sequence similarity 46, member A
FAM60A family with sequence similarity 60, member A
FASTKD5 FAST kinase domains 5
FN1 fibronectin 1
FOXO1 forkhead box O1
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA2 GATA binding protein 2
GGNBP2 gametogenetin binding protein 2
GSPT2 G1 to S phase transition 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HNMT histamine N-methyltransferase
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IRS2 insulin receptor substrate 2
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
KAZN kazrin, periplakin interacting protein
KIF5B kinesin family member 5B
KLHL21 kelch-like family member 21
KLK10 kallikrein-related peptidase 10
KLK5 kallikrein-related peptidase 5
KLK6 kallikrein-related peptidase 6
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT23 keratin 23, type I
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LDLR low density lipoprotein receptor
LINC00341 long intergenic non-protein coding RNA 341
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MED1 mediator complex subunit 1
MTSS1 metastasis suppressor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGDN neuroguidin, EIF4E binding protein
NR2F6 nuclear receptor subfamily 2, group F, member 6
NRIP1 nuclear receptor interacting protein 1
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1
NUP50 nucleoporin 50kDa
NUP62 nucleoporin 62kDa
NXT1 nuclear transport factor 2-like export factor 1
OPN3 opsin 3
PEG10 paternally expressed 10
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIN2 Ras and Rab interactor 2
RPP38 ribonuclease P/MRP 38kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUNX3 runt-related transcription factor 3
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SAP30 Sin3A-associated protein, 30kDa
SCEL sciellin
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERTAD2 SERTA domain containing 2
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLPI secretory leukocyte peptidase inhibitor
SMAD7 SMAD family member 7
SNAI2 snail family zinc finger 2
SNAP25 synaptosomal-associated protein, 25kDa
SOX9 SRY (sex determining region Y)-box 9
SPEN spen family transcriptional repressor
SQLE squalene epoxidase
TACSTD2 tumor-associated calcium signal transducer 2
TBP TATA box binding protein
TBX3 T-box 3
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TOB1 transducer of ERBB2, 1
TOB2 transducer of ERBB2, 2
UMPS uridine monophosphate synthetase
VEGFA vascular endothelial growth factor A
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF217 zinc finger protein 217
ZNF22 zinc finger protein 22