BRD-K79090631_CGP-60474_SKBR3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

383 genes differentially expressed following the BRD-K79090631_CGP-60474_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACOT13 acyl-CoA thioesterase 13
ADD3 adducin 3 (gamma)
ADGRE5 adhesion G protein-coupled receptor E5
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANPEP alanyl (membrane) aminopeptidase
ANXA1 annexin A1
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ASMTL acetylserotonin O-methyltransferase-like
ATF3 activating transcription factor 3
ATG12 autophagy related 12
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
BID BH3 interacting domain death agonist
BMP2 bone morphogenetic protein 2
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BPGM 2,3-bisphosphoglycerate mutase
BPHL biphenyl hydrolase-like (serine hydrolase)
CA12 carbonic anhydrase XII
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CAPG capping protein (actin filament), gelsolin-like
CBR3 carbonyl reductase 3
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CD3D CD3d molecule, delta (CD3-TCR complex)
CELF2 CUGBP, Elav-like family member 2
CEP350 centrosomal protein 350kDa
CEP70 centrosomal protein 70kDa
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKB creatine kinase, brain
CLC Charcot-Leyden crystal galectin
CLIC3 chloride intracellular channel 3
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
CRYAB crystallin, alpha B
CST7 cystatin F (leukocystatin)
CTGF connective tissue growth factor
CTSG cathepsin G
CXCL8 chemokine (C-X-C motif) ligand 8
DEPTOR DEP domain containing MTOR-interacting protein
DMD dystrophin
DSP desmoplakin
DUSP2 dual specificity phosphatase 2
ECHDC2 enoyl CoA hydratase domain containing 2
EGR1 early growth response 1
ELANE elastase, neutrophil expressed
EMP3 epithelial membrane protein 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ERBB4 erb-b2 receptor tyrosine kinase 4
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM107A family with sequence similarity 107, member A
FAM129A family with sequence similarity 129, member A
FAM8A1 family with sequence similarity 8, member A1
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FHL1 four and a half LIM domains 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FNDC3B fibronectin type III domain containing 3B
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXC1 forkhead box C1
FOXD1 forkhead box D1
FST follistatin
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GBE1 glucan (1,4-alpha-), branching enzyme 1
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GOLGA8H golgin A8 family, member H
GOLIM4 golgi integral membrane protein 4
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
GSTM2 glutathione S-transferase mu 2 (muscle)
HACD1 3-hydroxyacyl-CoA dehydratase 1
HAS1 hyaluronan synthase 1
HCLS1 hematopoietic cell-specific Lyn substrate 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HIST1H4C histone cluster 1, H4c
HMGN4 high mobility group nucleosomal binding domain 4
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IFRD2 interferon-related developmental regulator 2
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IL2RG interleukin 2 receptor, gamma
IQCK IQ motif containing K
IRS1 insulin receptor substrate 1
ITM2A integral membrane protein 2A
JUN jun proto-oncogene
KCTD12 potassium channel tetramerization domain containing 12
KLF9 Kruppel-like factor 9
LAMC2 laminin, gamma 2
LAMP3 lysosomal-associated membrane protein 3
LCN2 lipocalin 2
LRRC17 leucine rich repeat containing 17
LTBP1 latent transforming growth factor beta binding protein 1
MAN2A1 mannosidase, alpha, class 2A, member 1
MAOA monoamine oxidase A
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MATN2 matrilin 2
MBD4 methyl-CpG binding domain protein 4
MEF2C myocyte enhancer factor 2C
MFAP3L microfibrillar-associated protein 3-like
MFAP5 microfibrillar associated protein 5
MGP matrix Gla protein
MICB MHC class I polypeptide-related sequence B
MPO myeloperoxidase
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1M metallothionein 1M
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
MXRA7 matrix-remodelling associated 7
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NQO2 NAD(P)H dehydrogenase, quinone 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
ORM1 orosomucoid 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAM peptidylglycine alpha-amidating monooxygenase
PDLIM5 PDZ and LIM domain 5
PDZK1IP1 PDZK1 interacting protein 1
PERP PERP, TP53 apoptosis effector
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLAT plasminogen activator, tissue
PLBD1 phospholipase B domain containing 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POSTN periostin, osteoblast specific factor
PRR7 proline rich 7 (synaptic)
PTER phosphotriesterase related
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PVALB parvalbumin
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP1 retinol binding protein 1, cellular
RBP4 retinol binding protein 4, plasma
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPL31 ribosomal protein L31
SATB2 SATB homeobox 2
SCRG1 stimulator of chondrogenesis 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SMC1A structural maintenance of chromosomes 1A
SMYD3 SET and MYND domain containing 3
SORBS2 sorbin and SH3 domain containing 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRPR signal recognition particle receptor (docking protein)
SRSF7 serine/arginine-rich splicing factor 7
STC1 stanniocalcin 1
STK26 serine/threonine protein kinase 26
STXBP2 syntaxin binding protein 2
TF transferrin
TFPI2 tissue factor pathway inhibitor 2
TGFA transforming growth factor, alpha
THBS4 thrombospondin 4
TIMP3 TIMP metallopeptidase inhibitor 3
TLE2 transducin-like enhancer of split 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNNC1 troponin C type 1 (slow)
TNNT1 troponin T type 1 (skeletal, slow)
TRA2A transformer 2 alpha homolog (Drosophila)
TRBC1 T cell receptor beta constant 1
TSPAN1 tetraspanin 1
TTC3 tetratricopeptide repeat domain 3
TXNDC9 thioredoxin domain containing 9
TXNIP thioredoxin interacting protein
TYROBP TYRO protein tyrosine kinase binding protein
UBR2 ubiquitin protein ligase E3 component n-recognin 2
USP1 ubiquitin specific peptidase 1
VWA5A von Willebrand factor A domain containing 5A
WWTR1 WW domain containing transcription regulator 1
ZIC1 Zic family member 1
ZNF91 zinc finger protein 91
ZSCAN31 zinc finger and SCAN domain containing 31

decreased expression

Symbol Name
ACTB actin, beta
AHNAK AHNAK nucleoprotein
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARL4C ADP-ribosylation factor-like 4C
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATMIN ATM interactor
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BASP1 brain abundant, membrane attached signal protein 1
BCAM basal cell adhesion molecule (Lutheran blood group)
BCL6 B-cell CLL/lymphoma 6
BMP7 bone morphogenetic protein 7
BTBD3 BTB (POZ) domain containing 3
C3ORF14 chromosome 3 open reading frame 14
CA2 carbonic anhydrase II
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CANT1 calcium activated nucleotidase 1
CASC3 cancer susceptibility candidate 3
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDK1 cyclin-dependent kinase 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHGB chromogranin B
CKS1B CDC28 protein kinase regulatory subunit 1B
CLMN calmin (calponin-like, transmembrane)
CLTA clathrin, light chain A
CLU clusterin
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSRP1 cysteine and glycine-rich protein 1
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CX3CR1 chemokine (C-X3-C motif) receptor 1
DCK deoxycytidine kinase
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DHCR24 24-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
DPYSL2 dihydropyrimidinase-like 2
EDNRB endothelin receptor type B
EFNA1 ephrin-A1
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EIF4A1 eukaryotic translation initiation factor 4A1
EIF4A3 eukaryotic translation initiation factor 4A3
ELOVL1 ELOVL fatty acid elongase 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EXT1 exostosin glycosyltransferase 1
FASN fatty acid synthase
FGFR2 fibroblast growth factor receptor 2
FOXJ3 forkhead box J3
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GCH1 GTP cyclohydrolase 1
GDI2 GDP dissociation inhibitor 2
GSDMB gasdermin B
HMG20B high mobility group 20B
HN1L hematological and neurological expressed 1-like
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IGL immunoglobulin lambda locus
ILF2 interleukin enhancer binding factor 2
INHBB inhibin, beta B
IVNS1ABP influenza virus NS1A binding protein
JCHAIN joining chain of multimeric IgA and IgM
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KIAA0355 KIAA0355
KLF4 Kruppel-like factor 4 (gut)
KLK11 kallikrein-related peptidase 11
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT23 keratin 23, type I
KRT7 keratin 7, type II
LBR lamin B receptor
LIMCH1 LIM and calponin homology domains 1
LPCAT1 lysophosphatidylcholine acyltransferase 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAGED2 melanoma antigen family D2
MALT1 MALT1 paracaspase
MARCKS myristoylated alanine-rich protein kinase C substrate
MED24 mediator complex subunit 24
MELK maternal embryonic leucine zipper kinase
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MMP11 matrix metallopeptidase 11
MRPS30 mitochondrial ribosomal protein S30
MSL1 male-specific lethal 1 homolog (Drosophila)
MSMB microseminoprotein, beta-
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYH10 myosin, heavy chain 10, non-muscle
NEFL neurofilament, light polypeptide
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NMU neuromedin U
NOP56 NOP56 ribonucleoprotein
NOTCH2 notch 2
NPEPL1 aminopeptidase-like 1
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUP62 nucleoporin 62kDa
OPN3 opsin 3
P3H2 prolyl 3-hydroxylase 2
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PAPD7 PAP associated domain containing 7
PBX1 pre-B-cell leukemia homeobox 1
PCNA proliferating cell nuclear antigen
PDCD6 programmed cell death 6
PFDN4 prefoldin subunit 4
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PNP purine nucleoside phosphorylase
PON2 paraoxonase 2
PPA1 pyrophosphatase (inorganic) 1
PRSS2 protease, serine, 2 (trypsin 2)
PRUNE2 prune homolog 2 (Drosophila)
PSAP prosaposin
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB22A RAB22A, member RAS oncogene family
RAE1 ribonucleic acid export 1
RBM47 RNA binding motif protein 47
RET ret proto-oncogene
RIN2 Ras and Rab interactor 2
RPL22 ribosomal protein L22
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
RRM2 ribonucleotide reductase M2
SCAND1 SCAN domain containing 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SEC23B Sec23 homolog B (S. cerevisiae)
SEPT9 septin 9
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
SMC4 structural maintenance of chromosomes 4
SMCO4 single-pass membrane protein with coiled-coil domains 4
SOX2 SRY (sex determining region Y)-box 2
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPP1 secreted phosphoprotein 1
SRSF5 serine/arginine-rich splicing factor 5
SRSF6 serine/arginine-rich splicing factor 6
STAU1 staufen double-stranded RNA binding protein 1
STIP1 stress-induced phosphoprotein 1
STX16 syntaxin 16
STXBP1 syntaxin binding protein 1
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TARS threonyl-tRNA synthetase
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFF3 trefoil factor 3 (intestinal)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM9SF3 transmembrane 9 superfamily member 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TXLNA taxilin alpha
TXNRD1 thioredoxin reductase 1
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2I ubiquitin-conjugating enzyme E2I
UBE3C ubiquitin protein ligase E3C
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C
VCAM1 vascular cell adhesion molecule 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WIPF2 WAS/WASL interacting protein family, member 2
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZNF217 zinc finger protein 217