BRD-K79090631_CGP-60474_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

427 genes differentially expressed following the BRD-K79090631_CGP-60474_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD6 abhydrolase domain containing 6
ACVR1B activin A receptor, type IB
ADCY1 adenylate cyclase 1 (brain)
ADD3 adducin 3 (gamma)
ADGRF5 adhesion G protein-coupled receptor F5
ADIRF adipogenesis regulatory factor
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANXA1 annexin A1
APLP2 amyloid beta (A4) precursor-like protein 2
AQP3 aquaporin 3 (Gill blood group)
ARL4C ADP-ribosylation factor-like 4C
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASPN asporin
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATRAID all-trans retinoic acid-induced differentiation factor
BBX bobby sox homolog (Drosophila)
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCL4 chemokine (C-C motif) ligand 4
CCL8 chemokine (C-C motif) ligand 8
CD3D CD3d molecule, delta (CD3-TCR complex)
CD47 CD47 molecule
CD9 CD9 molecule
CDC42 cell division cycle 42
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEP70 centrosomal protein 70kDa
CERS6 ceramide synthase 6
CFI complement factor I
CKB creatine kinase, brain
CLEC2B C-type lectin domain family 2, member B
CLU clusterin
CMC4 C-x(9)-C motif containing 4
COG5 component of oligomeric golgi complex 5
COL2A1 collagen, type II, alpha 1
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
COLEC12 collectin sub-family member 12
CPM carboxypeptidase M
CPVL carboxypeptidase, vitellogenic-like
CRTAP cartilage associated protein
CSRP2 cysteine and glycine-rich protein 2
CTSO cathepsin O
CTTN cortactin
CUL4B cullin 4B
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CYBRD1 cytochrome b reductase 1
DDAH1 dimethylarginine dimethylaminohydrolase 1
DES desmin
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
ECHDC2 enoyl CoA hydratase domain containing 2
ECI1 enoyl-CoA delta isomerase 1
ECM1 extracellular matrix protein 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EID1 EP300 interacting inhibitor of differentiation 1
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
ENSA endosulfine alpha
EPAS1 endothelial PAS domain protein 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPCAM epithelial cell adhesion molecule
ERP29 endoplasmic reticulum protein 29
F11R F11 receptor
F3 coagulation factor III (thromboplastin, tissue factor)
F8 coagulation factor VIII, procoagulant component
FAM129A family with sequence similarity 129, member A
FBLN1 fibulin 1
FMO2 flavin containing monooxygenase 2 (non-functional)
FOLR1 folate receptor 1 (adult)
FOXF1 forkhead box F1
FRY furry homolog (Drosophila)
FST follistatin
G0S2 G0/G1 switch 2
GAA glucosidase, alpha; acid
GALC galactosylceramidase
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GDE1 glycerophosphodiester phosphodiesterase 1
GM2A GM2 ganglioside activator
GNS glucosamine (N-acetyl)-6-sulfatase
GOLM1 golgi membrane protein 1
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GSTP1 glutathione S-transferase pi 1
GUK1 guanylate kinase 1
GUSB glucuronidase, beta
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIP1 huntingtin interacting protein 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-G major histocompatibility complex, class I, G
HMGN4 high mobility group nucleosomal binding domain 4
HRSP12 heat-responsive protein 12
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSPB8 heat shock 22kDa protein 8
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDS iduronate 2-sulfatase
IFI30 interferon, gamma-inducible protein 30
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IFT57 intraflagellar transport 57
IGFBP3 insulin-like growth factor binding protein 3
IL6ST interleukin 6 signal transducer
IL7R interleukin 7 receptor
ISYNA1 inositol-3-phosphate synthase 1
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDM4B lysine (K)-specific demethylase 4B
KDM5A lysine (K)-specific demethylase 5A
KIAA0100 KIAA0100
KRT19 keratin 19, type I
LAGE3 L antigen family, member 3
LAMP2 lysosomal-associated membrane protein 2
LDOC1 leucine zipper, down-regulated in cancer 1
LEF1 lymphoid enhancer-binding factor 1
LMO4 LIM domain only 4
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LTBP1 latent transforming growth factor beta binding protein 1
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MAN2B1 mannosidase, alpha, class 2B, member 1
MAN2B2 mannosidase, alpha, class 2B, member 2
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MDFIC MyoD family inhibitor domain containing
MED13L mediator complex subunit 13-like
METRN meteorin, glial cell differentiation regulator
MFAP2 microfibrillar-associated protein 2
MGP matrix Gla protein
MME membrane metallo-endopeptidase
MSN moesin
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1M metallothionein 1M
MXI1 MAX interactor 1, dimerization protein
NEBL nebulette
NGRN neugrin, neurite outgrowth associated
NMU neuromedin U
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRP1 neuropilin 1
NTS neurotensin
NUCB1 nucleobindin 1
NUPR1 nuclear protein, transcriptional regulator, 1
NXT2 nuclear transport factor 2-like export factor 2
OLFM4 olfactomedin 4
P3H2 prolyl 3-hydroxylase 2
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PALLD palladin, cytoskeletal associated protein
PCP4 Purkinje cell protein 4
PCYOX1 prenylcysteine oxidase 1
PDZK1 PDZ domain containing 1
PER3 period circadian clock 3
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PIGT phosphatidylinositol glycan anchor biosynthesis, class T
PLS3 plastin 3
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POSTN periostin, osteoblast specific factor
PPAP2A phosphatidic acid phosphatase type 2A
PPARG peroxisome proliferator-activated receptor gamma
PPT1 palmitoyl-protein thioesterase 1
PRAME preferentially expressed antigen in melanoma
PROS1 protein S (alpha)
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PSPH phosphoserine phosphatase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBP1 retinol binding protein 1, cellular
RCAN1 regulator of calcineurin 1
RGS1 regulator of G-protein signaling 1
RGS10 regulator of G-protein signaling 10
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RHOBTB3 Rho-related BTB domain containing 3
RPA3 replication protein A3, 14kDa
RRAGD Ras-related GTP binding D
RTN1 reticulon 1
S100A4 S100 calcium binding protein A4
SCARB2 scavenger receptor class B, member 2
SCD5 stearoyl-CoA desaturase 5
SCPEP1 serine carboxypeptidase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPW1 selenoprotein W, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SH3GLB2 SH3-domain GRB2-like endophilin B2
SH3YL1 SH3 and SYLF domain containing 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLIT2 slit homolog 2 (Drosophila)
SOD1 superoxide dismutase 1, soluble
SORD sorbitol dehydrogenase
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPP1 secreted phosphoprotein 1
SQRDL sulfide quinone reductase-like (yeast)
SSPN sarcospan
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAT1 signal transducer and activator of transcription 1, 91kDa
STC1 stanniocalcin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK39 serine threonine kinase 39
STXBP2 syntaxin binding protein 2
SULF1 sulfatase 1
SVIL supervillin
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
TCTN1 tectonic family member 1
TGFA transforming growth factor, alpha
TIAM1 T-cell lymphoma invasion and metastasis 1
TKTL1 transketolase-like 1
TM2D1 TM2 domain containing 1
TMEM106B transmembrane protein 106B
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM47 transmembrane protein 47
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
TRBC1 T cell receptor beta constant 1
TRH thyrotropin-releasing hormone
TRIL TLR4 interactor with leucine-rich repeats
TSPAN13 tetraspanin 13
TSPAN31 tetraspanin 31
TSPAN6 tetraspanin 6
TSPAN7 tetraspanin 7
TTC3 tetratricopeptide repeat domain 3
TTC39A tetratricopeptide repeat domain 39A
TUSC3 tumor suppressor candidate 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WARS tryptophanyl-tRNA synthetase
WIF1 WNT inhibitory factor 1
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
ZNF264 zinc finger protein 264

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C2 aldo-keto reductase family 1, member C2
ALCAM activated leukocyte cell adhesion molecule
ARF6 ADP-ribosylation factor 6
ARG1 arginase 1
ASS1 argininosuccinate synthase 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BAX BCL2-associated X protein
BPHL biphenyl hydrolase-like (serine hydrolase)
BTBD3 BTB (POZ) domain containing 3
CA2 carbonic anhydrase II
CALML5 calmodulin-like 5
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL20 chemokine (C-C motif) ligand 20
CCNA2 cyclin A2
CCNB2 cyclin B2
CD36 CD36 molecule (thrombospondin receptor)
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDK1 cyclin-dependent kinase 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKS2 CDC28 protein kinase regulatory subunit 2
CLTA clathrin, light chain A
CLTC clathrin, heavy chain (Hc)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL14 chemokine (C-X-C motif) ligand 14
DAAM1 dishevelled associated activator of morphogenesis 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ERBB2 erb-b2 receptor tyrosine kinase 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FASTKD5 FAST kinase domains 5
FERMT1 fermitin family member 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GLDC glycine dehydrogenase (decarboxylating)
GLRX glutaredoxin (thioltransferase)
GOLT1B golgi transport 1B
GSPT2 G1 to S phase transition 2
H2AFX H2A histone family, member X
HEATR1 HEAT repeat containing 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IER5 immediate early response 5
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IL32 interleukin 32
IVNS1ABP influenza virus NS1A binding protein
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KDM5D lysine (K)-specific demethylase 5D
KIAA0101 KIAA0101
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KLK5 kallikrein-related peptidase 5
KLK6 kallikrein-related peptidase 6
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT10 keratin 10, type I
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT23 keratin 23, type I
KRT81 keratin 81, type II
LDLR low density lipoprotein receptor
LOC100505650 uncharacterized LOC100505650
LTF lactotransferrin
LY6D lymphocyte antigen 6 complex, locus D
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MCAM melanoma cell adhesion molecule
MED17 mediator complex subunit 17
MELK maternal embryonic leucine zipper kinase
METTL3 methyltransferase like 3
MKI67 marker of proliferation Ki-67
MREG melanoregulin
MRPS2 mitochondrial ribosomal protein S2
MTUS1 microtubule associated tumor suppressor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
N4BP2L2 NEDD4 binding protein 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGDN neuroguidin, EIF4E binding protein
NOP56 NOP56 ribonucleoprotein
NR1H2 nuclear receptor subfamily 1, group H, member 2
NSG1 neuron specific gene family member 1
NUP62 nucleoporin 62kDa
OPN3 opsin 3
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLK1 polo-like kinase 1
PLP1 proteolipid protein 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POU2AF1 POU class 2 associating factor 1
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2
PRPF4B pre-mRNA processing factor 4B
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PUF60 poly-U binding splicing factor 60KDa
RAE1 ribonucleic acid export 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RDX radixin
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF38 ring finger protein 38
RNPS1 RNA binding protein S1, serine-rich domain
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRM2 ribonucleotide reductase M2
RRP1B ribosomal RNA processing 1B
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCAND1 SCAN domain containing 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC38A2 solute carrier family 38, member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMAD7 SMAD family member 7
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPB2 small nuclear ribonucleoprotein polypeptide B
SOX4 SRY (sex determining region Y)-box 4
STAB1 stabilin 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBP TATA box binding protein
TCP1 t-complex 1
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TMEM97 transmembrane protein 97
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TXLNA taxilin alpha
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
USP22 ubiquitin specific peptidase 22
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VCAN versican
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZMYM2 zinc finger, MYM-type 2