BRD-K79090631_CGP-60474_BT20_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

238 genes differentially expressed following the BRD-K79090631_CGP-60474_BT20_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACPP acid phosphatase, prostate
ACSL5 acyl-CoA synthetase long-chain family member 5
ADGRF5 adhesion G protein-coupled receptor F5
AHSG alpha-2-HS-glycoprotein
ALB albumin
ALCAM activated leukocyte cell adhesion molecule
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AMBP alpha-1-microglobulin/bikunin precursor
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOB apolipoprotein B
APOC3 apolipoprotein C-III
APOH apolipoprotein H (beta-2-glycoprotein I)
ASPN asporin
ASRGL1 asparaginase like 1
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
BAD BCL2-associated agonist of cell death
C9 complement component 9
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
CFB complement factor B
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHN2 chimerin 2
CLGN calmegin
CLIC5 chloride intracellular channel 5
COL3A1 collagen, type III, alpha 1
COL5A1 collagen, type V, alpha 1
CP ceruloplasmin (ferroxidase)
CRLF1 cytokine receptor-like factor 1
CRP C-reactive protein, pentraxin-related
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DACH1 dachshund family transcription factor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL2 dihydropyrimidinase-like 2
DSE dermatan sulfate epimerase
EIF5A eukaryotic translation initiation factor 5A
F13A1 coagulation factor XIII, A1 polypeptide
FABP1 fatty acid binding protein 1, liver
FGL1 fibrinogen-like 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLRT2 fibronectin leucine rich transmembrane protein 2
GC group-specific component (vitamin D binding protein)
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GHITM growth hormone inducible transmembrane protein
GNG10 guanine nucleotide binding protein (G protein), gamma 10
GPM6A glycoprotein M6A
HAMP hepcidin antimicrobial peptide
HNMT histamine N-methyltransferase
HOMER2 homer scaffolding protein 2
HRG histidine-rich glycoprotein
IGFBP1 insulin-like growth factor binding protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP7 insulin-like growth factor binding protein 7
IQGAP2 IQ motif containing GTPase activating protein 2
ITGAV integrin, alpha V
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3
ITM2A integral membrane protein 2A
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCTD12 potassium channel tetramerization domain containing 12
LAPTM4B lysosomal protein transmembrane 4 beta
LBH limb bud and heart development
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LMO4 LIM domain only 4
LYPLA1 lysophospholipase I
MAGEA6 melanoma antigen family A6
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MLPH melanophilin
NEK7 NIMA-related kinase 7
NLRP2 NLR family, pyrin domain containing 2
NREP neuronal regeneration related protein
PGK1 phosphoglycerate kinase 1
PHYH phytanoyl-CoA 2-hydroxylase
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PSPH phosphoserine phosphatase
PXDN peroxidasin
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
REEP5 receptor accessory protein 5
RNASE6 ribonuclease, RNase A family, k6
RPS4Y1 ribosomal protein S4, Y-linked 1
SCML1 sex comb on midleg-like 1 (Drosophila)
SDC2 syndecan 2
SDCBP syndecan binding protein (syntenin)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SFRP4 secreted frizzled-related protein 4
SNAP25 synaptosomal-associated protein, 25kDa
SPINK1 serine peptidase inhibitor, Kazal type 1
STAB1 stabilin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
THY1 Thy-1 cell surface antigen
TMC5 transmembrane channel-like 5
TMED7 transmembrane emp24 protein transport domain containing 7
TMEM14B transmembrane protein 14B
TPM2 tropomyosin 2 (beta)
TSPAN8 tetraspanin 8
TUBA1A tubulin, alpha 1a
UBE2E3 ubiquitin-conjugating enzyme E2E 3
VIM vimentin
VNN1 vanin 1
ZNF532 zinc finger protein 532

decreased expression

Symbol Name
ADM adrenomedullin
AHNAK2 AHNAK nucleoprotein 2
APOLD1 apolipoprotein L domain containing 1
AREG amphiregulin
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
AURKA aurora kinase A
BAMBI BMP and activin membrane-bound inhibitor
BCL6 B-cell CLL/lymphoma 6
BHLHE40 basic helix-loop-helix family, member e40
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CA12 carbonic anhydrase XII
CBR3 carbonyl reductase 3
CCNE2 cyclin E2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CTGF connective tissue growth factor
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLX2 distal-less homeobox 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DSG3 desmoglein 3
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EGR2 early growth response 2
EGR3 early growth response 3
FASTKD5 FAST kinase domains 5
FMO1 flavin containing monooxygenase 1
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
GADD45B growth arrest and DNA-damage-inducible, beta
GATA2 GATA binding protein 2
GATA3 GATA binding protein 3
GEM GTP binding protein overexpressed in skeletal muscle
GNAS GNAS complex locus
HBB hemoglobin, beta
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
HOXC6 homeobox C6
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IGFBP6 insulin-like growth factor binding protein 6
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
JUNB jun B proto-oncogene
KANK1 KN motif and ankyrin repeat domains 1
KLF10 Kruppel-like factor 10
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KRT81 keratin 81, type II
LTF lactotransferrin
LYPD3 LY6/PLAUR domain containing 3
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MALL mal, T-cell differentiation protein-like
MAT2A methionine adenosyltransferase II, alpha
MKNK2 MAP kinase interacting serine/threonine kinase 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFE2L2 nuclear factor, erythroid 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOP56 NOP56 ribonucleoprotein
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKP1 plakophilin 1
PLK2 polo-like kinase 2
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PTPRO protein tyrosine phosphatase, receptor type, O
RAP2B RAP2B, member of RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM15 RNA binding motif protein 15
RBM34 RNA binding motif protein 34
RGS1 regulator of G-protein signaling 1
S100P S100 calcium binding protein P
SCAF8 SR-related CTD-associated factor 8
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLPI secretory leukocyte peptidase inhibitor
SMAD7 SMAD family member 7
SOX9 SRY (sex determining region Y)-box 9
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR2B small proline-rich protein 2B
SPRR3 small proline-rich protein 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFB2M transcription factor B2, mitochondrial
TFF1 trefoil factor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TOX3 TOX high mobility group box family member 3
TPD52L1 tumor protein D52-like 1
TSC22D2 TSC22 domain family, member 2
TXNIP thioredoxin interacting protein
WEE1 WEE1 G2 checkpoint kinase
WNT5A wingless-type MMTV integration site family, member 5A
ZBTB18 zinc finger and BTB domain containing 18
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2