BRD-K78599730_manumycin A_RKO_6.0_h_9.07999992371_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

168 genes differentially expressed following the BRD-K78599730_manumycin A_RKO_6.0_h_9.07999992371_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOT13 acyl-CoA thioesterase 13
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AK5 adenylate kinase 5
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
BAG3 BCL2-associated athanogene 3
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
BMP4 bone morphogenetic protein 4
C3ORF14 chromosome 3 open reading frame 14
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD1E CD1e molecule
CD44 CD44 molecule (Indian blood group)
CD52 CD52 molecule
CD9 CD9 molecule
CEP57 centrosomal protein 57kDa
CHMP4A charged multivesicular body protein 4A
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
COL5A2 collagen, type V, alpha 2
COLEC12 collectin sub-family member 12
CPE carboxypeptidase E
CREM cAMP responsive element modulator
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
EFHD1 EF-hand domain family, member D1
EIF5 eukaryotic translation initiation factor 5
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPAS1 endothelial PAS domain protein 1
FABP4 fatty acid binding protein 4, adipocyte
FDX1 ferredoxin 1
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FN1 fibronectin 1
FTH1 ferritin, heavy polypeptide 1
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
HES1 hes family bHLH transcription factor 1
HIST1H2BG histone cluster 1, H2bg
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA2 heat shock 70kDa protein 2
HSPH1 heat shock 105kDa/110kDa protein 1
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
MAN1A1 mannosidase, alpha, class 1A, member 1
METRN meteorin, glial cell differentiation regulator
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP12 matrix metallopeptidase 12
MPO myeloperoxidase
NEBL nebulette
NPTX2 neuronal pentraxin II
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
PBX1 pre-B-cell leukemia homeobox 1
PDLIM3 PDZ and LIM domain 3
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLCL1 phospholipase C-like 1
POSTN periostin, osteoblast specific factor
PRKCI protein kinase C, iota
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
S100A8 S100 calcium binding protein A8
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERINC3 serine incorporator 3
SERINC5 serine incorporator 5
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SULF1 sulfatase 1
TBX3 T-box 3
TCF4 transcription factor 4
THBS1 thrombospondin 1
THEMIS2 thymocyte selection associated family member 2
TPD52 tumor protein D52
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRPS1 trichorhinophalangeal syndrome I
UGP2 UDP-glucose pyrophosphorylase 2
VCAN versican
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACLY ATP citrate lyase
ACSL1 acyl-CoA synthetase long-chain family member 1
ANKRD10 ankyrin repeat domain 10
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BIN1 bridging integrator 1
BTK Bruton agammaglobulinemia tyrosine kinase
C2CD2 C2 calcium-dependent domain containing 2
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CCND1 cyclin D1
CCNF cyclin F
CD47 CD47 molecule
CDC42 cell division cycle 42
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHERP calcium homeostasis endoplasmic reticulum protein
CSTA cystatin A (stefin A)
CXCL8 chemokine (C-X-C motif) ligand 8
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
EDF1 endothelial differentiation-related factor 1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ERBB2 erb-b2 receptor tyrosine kinase 2
FLNA filamin A, alpha
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GOLM1 golgi membrane protein 1
GRWD1 glutamate-rich WD repeat containing 1
GSTP1 glutathione S-transferase pi 1
IER3 immediate early response 3
IFITM2 interferon induced transmembrane protein 2
IGFBP6 insulin-like growth factor binding protein 6
ITGB5 integrin, beta 5
KAZN kazrin, periplakin interacting protein
KIF2C kinesin family member 2C
KLF4 Kruppel-like factor 4 (gut)
KRT10 keratin 10, type I
LBR lamin B receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIMA1 LIM domain and actin binding 1
LPCAT1 lysophosphatidylcholine acyltransferase 1
LTBP3 latent transforming growth factor beta binding protein 3
LY6E lymphocyte antigen 6 complex, locus E
MAP2K3 mitogen-activated protein kinase kinase 3
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MRPL12 mitochondrial ribosomal protein L12
MTA1 metastasis associated 1
MTCL1 microtubule crosslinking factor 1
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NUP62 nucleoporin 62kDa
PEBP1 phosphatidylethanolamine binding protein 1
PLAC8 placenta-specific 8
PODXL podocalyxin-like
PRDX2 peroxiredoxin 2
PRR7 proline rich 7 (synaptic)
PTTG1IP pituitary tumor-transforming 1 interacting protein
PYCARD PYD and CARD domain containing
RPL36 ribosomal protein L36
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP1B ribosomal RNA processing 1B
SCAND1 SCAN domain containing 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SORD sorbitol dehydrogenase
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIO trio Rho guanine nucleotide exchange factor
TSPAN8 tetraspanin 8
UBE2S ubiquitin-conjugating enzyme E2S
UGCG UDP-glucose ceramide glucosyltransferase
VAT1 vesicle amine transport 1
VGLL4 vestigial-like family member 4
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2