BRD-K78599730_manumycin A_MCF7_24.0_h_9.08_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

66 genes differentially expressed following the BRD-K78599730_manumycin A_MCF7_24.0_h_9.08_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADAM10 ADAM metallopeptidase domain 10
AKR1C1 aldo-keto reductase family 1, member C1
AMIGO2 adhesion molecule with Ig-like domain 2
CCL5 chemokine (C-C motif) ligand 5
CD24 CD24 molecule
CTSL cathepsin L
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
HMOX1 heme oxygenase 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
JAG1 jagged 1
RAP1GAP RAP1 GTPase activating protein
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SNAI2 snail family zinc finger 2
SRGN serglycin
TGFBI transforming growth factor, beta-induced, 68kDa
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TXNRD1 thioredoxin reductase 1
WNT5A wingless-type MMTV integration site family, member 5A
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
BARD1 BRCA1 associated RING domain 1
BIRC5 baculoviral IAP repeat containing 5
CCNF cyclin F
CDC25A cell division cycle 25A
CENPA centromere protein A
CENPU centromere protein U
CXCL12 chemokine (C-X-C motif) ligand 12
DCK deoxycytidine kinase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F8 E2F transcription factor 8
FEN1 flap structure-specific endonuclease 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HELLS helicase, lymphoid-specific
HOXC6 homeobox C6
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM7 minichromosome maintenance complex component 7
MKI67 marker of proliferation Ki-67
MUC1 mucin 1, cell surface associated
NUSAP1 nucleolar and spindle associated protein 1
PBK PDZ binding kinase
PLK1 polo-like kinase 1
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSRC1 proline/serine-rich coiled-coil 1
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RRM2 ribonucleotide reductase M2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
STMN1 stathmin 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TTK TTK protein kinase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S