BRD-K78599730_manumycin A_H1299_6.0_h_9.07999992371_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

146 genes differentially expressed following the BRD-K78599730_manumycin A_H1299_6.0_h_9.07999992371_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
ANKRD11 ankyrin repeat domain 11
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
ATP11B ATPase, class VI, type 11B
BAG3 BCL2-associated athanogene 3
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL6 B-cell CLL/lymphoma 6
BPHL biphenyl hydrolase-like (serine hydrolase)
C3ORF14 chromosome 3 open reading frame 14
C9ORF3 chromosome 9 open reading frame 3
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
DDIT3 DNA-damage-inducible transcript 3
DMTF1 cyclin D binding myb-like transcription factor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSP desmoplakin
FMOD fibromodulin
FOXF2 forkhead box F2
FRZB frizzled-related protein
GADD45B growth arrest and DNA-damage-inducible, beta
GAS6 growth arrest-specific 6
GLUL glutamate-ammonia ligase
GOLGA4 golgin A4
GREM1 gremlin 1, DAN family BMP antagonist
GULP1 GULP, engulfment adaptor PTB domain containing 1
HDAC6 histone deacetylase 6
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
LTBP1 latent transforming growth factor beta binding protein 1
MAP7 microtubule-associated protein 7
MOXD1 monooxygenase, DBH-like 1
NDNF neuron-derived neurotrophic factor
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRCAM neuronal cell adhesion molecule
NRIP1 nuclear receptor interacting protein 1
PELI1 pellino E3 ubiquitin protein ligase 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
REG3A regenerating islet-derived 3 alpha
S100A8 S100 calcium binding protein A8
SCGB2A1 secretoglobin, family 2A, member 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNX7 sorting nexin 7
SPON1 spondin 1, extracellular matrix protein
SPON2 spondin 2, extracellular matrix protein
SST somatostatin
SULF1 sulfatase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFBI transforming growth factor, beta-induced, 68kDa
TKT transketolase
TNPO1 transportin 1
TXNL4B thioredoxin-like 4B
WNT5A wingless-type MMTV integration site family, member 5A
XBP1 X-box binding protein 1
YBX3 Y box binding protein 3
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF331 zinc finger protein 331
ZNF394 zinc finger protein 394

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ADD3 adducin 3 (gamma)
AIM1 absent in melanoma 1
AK4 adenylate kinase 4
ANPEP alanyl (membrane) aminopeptidase
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BASP1 brain abundant, membrane attached signal protein 1
BID BH3 interacting domain death agonist
BIRC3 baculoviral IAP repeat containing 3
BST2 bone marrow stromal cell antigen 2
CAPG capping protein (actin filament), gelsolin-like
CAST calpastatin
CCNA2 cyclin A2
CCNF cyclin F
CENPA centromere protein A
CTSC cathepsin C
DFNA5 deafness, autosomal dominant 5
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
FAM129A family with sequence similarity 129, member A
FAM69A family with sequence similarity 69, member A
GLS glutaminase
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GRB14 growth factor receptor-bound protein 14
IFI16 interferon, gamma-inducible protein 16
IGFBP4 insulin-like growth factor binding protein 4
IGFBP7 insulin-like growth factor binding protein 7
IL27RA interleukin 27 receptor, alpha
IL6ST interleukin 6 signal transducer
KRT7 keratin 7, type II
L1CAM L1 cell adhesion molecule
LDHB lactate dehydrogenase B
LGALS3 lectin, galactoside-binding, soluble, 3
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MARCKS myristoylated alanine-rich protein kinase C substrate
MATN2 matrilin 2
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MRPS30 mitochondrial ribosomal protein S30
MSMO1 methylsterol monooxygenase 1
MTERF3 mitochondrial transcription termination factor 3
MXRA7 matrix-remodelling associated 7
NFIB nuclear factor I/B
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NSDHL NAD(P) dependent steroid dehydrogenase-like
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G16 phospholipase A2, group XVI
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PNMA1 paraneoplastic Ma antigen 1
QDPR quinoid dihydropteridine reductase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPS11 ribosomal protein S11
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SDC4 syndecan 4
SEPT6 septin 6
SFRP1 secreted frizzled-related protein 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SRPX sushi-repeat containing protein, X-linked
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TP53 tumor protein p53
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble