BRD-K78431006_crizotinib_SKBR3_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

90 genes differentially expressed following the BRD-K78431006_crizotinib_SKBR3_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C2 aldo-keto reductase family 1, member C2
AXL AXL receptor tyrosine kinase
CA12 carbonic anhydrase XII
CLU clusterin
CXCL11 chemokine (C-X-C motif) ligand 11
CYBA cytochrome b-245, alpha polypeptide
DUSP4 dual specificity phosphatase 4
ESR1 estrogen receptor 1
FADS1 fatty acid desaturase 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
IGFBP6 insulin-like growth factor binding protein 6
INSIG1 insulin induced gene 1
LPAR1 lysophosphatidic acid receptor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK13 mitogen-activated protein kinase 13
OAT ornithine aminotransferase
PDGFA platelet-derived growth factor alpha polypeptide
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TUBB2A tubulin, beta 2A class IIa
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ALDOB aldolase B, fructose-bisphosphate
ANOS1 anosmin 1
ANXA3 annexin A3
ATP10B ATPase, class V, type 10B
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
CD24 CD24 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CERS6 ceramide synthase 6
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN1 chimerin 1
CLC Charcot-Leyden crystal galectin
CLIC5 chloride intracellular channel 5
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CXADR coxsackie virus and adenovirus receptor
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK3 dickkopf WNT signaling pathway inhibitor 3
DOK5 docking protein 5
DSC2 desmocollin 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FAS Fas cell surface death receptor
FBN1 fibrillin 1
FGFR3 fibroblast growth factor receptor 3
FILIP1L filamin A interacting protein 1-like
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GREM1 gremlin 1, DAN family BMP antagonist
HEPH hephaestin
ITGA6 integrin, alpha 6
KLF5 Kruppel-like factor 5 (intestinal)
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KLK8 kallikrein-related peptidase 8
LOX lysyl oxidase
LPL lipoprotein lipase
LYZ lysozyme
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MEF2C myocyte enhancer factor 2C
MMP12 matrix metallopeptidase 12
MYLK myosin light chain kinase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NNMT nicotinamide N-methyltransferase
NPR3 natriuretic peptide receptor 3
OSBPL1A oxysterol binding protein-like 1A
PBX3 pre-B-cell leukemia homeobox 3
PDGFC platelet derived growth factor C
PROM1 prominin 1
REG1A regenerating islet-derived 1 alpha
RGS1 regulator of G-protein signaling 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100P S100 calcium binding protein P
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPON1 spondin 1, extracellular matrix protein
SULF1 sulfatase 1
TAGLN transgelin
TSPAN12 tetraspanin 12
TYRP1 tyrosinase-related protein 1
VCAN versican
WNT5A wingless-type MMTV integration site family, member 5A