BRD-K78431006_crizotinib_SKBR3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

91 genes differentially expressed following the BRD-K78431006_crizotinib_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BEX1 brain expressed, X-linked 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CADM1 cell adhesion molecule 1
CCNE2 cyclin E2
CD14 CD14 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
DLK1 delta-like 1 homolog (Drosophila)
DMD dystrophin
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FGG fibrinogen gamma chain
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GBP1 guanylate binding protein 1, interferon-inducible
GLUL glutamate-ammonia ligase
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
HK2 hexokinase 2
HMGA2 high mobility group AT-hook 2
HOPX HOP homeobox
ITM2A integral membrane protein 2A
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCTD12 potassium channel tetramerization domain containing 12
MTA1 metastasis associated 1
MYLK myosin light chain kinase
NDRG1 N-myc downstream regulated 1
NEFL neurofilament, light polypeptide
NEFM neurofilament, medium polypeptide
NR2F1 nuclear receptor subfamily 2, group F, member 1
NRN1 neuritin 1
OLFM1 olfactomedin 1
PEG3 paternally expressed 3
PFKP phosphofructokinase, platelet
PTN pleiotrophin
RAD51C RAD51 paralog C
SEPP1 selenoprotein P, plasma, 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SOX9 SRY (sex determining region Y)-box 9
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
UBE2S ubiquitin-conjugating enzyme E2S

decreased expression

Symbol Name
AEBP1 AE binding protein 1
AKAP9 A kinase (PRKA) anchor protein 9
AKR1C3 aldo-keto reductase family 1, member C3
ASPN asporin
CFH complement factor H
CHN1 chimerin 1
COMP cartilage oligomeric matrix protein
CTBP2 C-terminal binding protein 2
CTGF connective tissue growth factor
DPT dermatopontin
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GATA2 GATA binding protein 2
GOLT1B golgi transport 1B
GSTT1 glutathione S-transferase theta 1
HBB hemoglobin, beta
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
INHBA inhibin, beta A
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
MECOM MDS1 and EVI1 complex locus
MFAP2 microfibrillar-associated protein 2
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1M metallothionein 1M
MT1X metallothionein 1X
MYLIP myosin regulatory light chain interacting protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NNMT nicotinamide N-methyltransferase
PECAM1 platelet/endothelial cell adhesion molecule 1
PLAGL1 pleiomorphic adenoma gene-like 1
PRKCD protein kinase C, delta
PROM1 prominin 1
PTPRD protein tyrosine phosphatase, receptor type, D
RUFY2 RUN and FYVE domain containing 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SPP1 secreted phosphoprotein 1
STXBP2 syntaxin binding protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN13 tetraspanin 13
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAMP8 vesicle-associated membrane protein 8
VWA5A von Willebrand factor A domain containing 5A
XIST X inactive specific transcript (non-protein coding)
ZBTB20 zinc finger and BTB domain containing 20