BRD-K78431006_crizotinib_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

87 genes differentially expressed following the BRD-K78431006_crizotinib_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ASS1 argininosuccinate synthase 1
BIK BCL2-interacting killer (apoptosis-inducing)
BLNK B-cell linker
C7 complement component 7
CCL20 chemokine (C-C motif) ligand 20
CCNB2 cyclin B2
CLEC11A C-type lectin domain family 11, member A
COG7 component of oligomeric golgi complex 7
CXCL8 chemokine (C-X-C motif) ligand 8
ELANE elastase, neutrophil expressed
F13A1 coagulation factor XIII, A1 polypeptide
GYPC glycophorin C (Gerbich blood group)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ISLR immunoglobulin superfamily containing leucine-rich repeat
JADE2 jade family PHD finger 2
KIAA0101 KIAA0101
LAPTM5 lysosomal protein transmembrane 5
MKNK1 MAP kinase interacting serine/threonine kinase 1
MMP9 matrix metallopeptidase 9
MSLN mesothelin
NEFL neurofilament, light polypeptide
NLRP2 NLR family, pyrin domain containing 2
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
NUSAP1 nucleolar and spindle associated protein 1
PEG3 paternally expressed 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRUNE2 prune homolog 2 (Drosophila)
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SPON2 spondin 2, extracellular matrix protein
SPP1 secreted phosphoprotein 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STAR steroidogenic acute regulatory protein
TCF4 transcription factor 4
TLE4 transducin-like enhancer of split 4
UBE2B ubiquitin-conjugating enzyme E2B
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA5 annexin A5
CBX1 chromobox homolog 1
CD59 CD59 molecule, complement regulatory protein
CLU clusterin
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTSZ cathepsin Z
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FABP4 fatty acid binding protein 4, adipocyte
FN1 fibronectin 1
HAT1 histone acetyltransferase 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
ISG15 ISG15 ubiquitin-like modifier
KDM5D lysine (K)-specific demethylase 5D
KYNU kynureninase
LPL lipoprotein lipase
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MX1 MX dynamin-like GTPase 1
NFIB nuclear factor I/B
NRIP1 nuclear receptor interacting protein 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POSTN periostin, osteoblast specific factor
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RAB4A RAB4A, member RAS oncogene family
SCUBE2 signal peptide, CUB domain, EGF-like 2
SFN stratifin
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SOX9 SRY (sex determining region Y)-box 9
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT1 signal transducer and activator of transcription 1, 91kDa
THBS1 thrombospondin 1
TICAM1 toll-like receptor adaptor molecule 1
TNS1 tensin 1
TWIST1 twist family bHLH transcription factor 1
WIF1 WNT inhibitory factor 1
ZBTB18 zinc finger and BTB domain containing 18