BRD-K78431006_crizotinib_MCF7_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

112 genes differentially expressed following the BRD-K78431006_crizotinib_MCF7_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
APOLD1 apolipoprotein L domain containing 1
ARID4B AT rich interactive domain 4B (RBP1-like)
ATHL1 ATH1, acid trehalase-like 1 (yeast)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BIRC2 baculoviral IAP repeat containing 2
CD24 CD24 molecule
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC2B C-type lectin domain family 2, member B
CLU clusterin
CP ceruloplasmin (ferroxidase)
CSRP2 cysteine and glycine-rich protein 2
CXCL12 chemokine (C-X-C motif) ligand 12
CYR61 cysteine-rich, angiogenic inducer, 61
DHRS2 dehydrogenase/reductase (SDR family) member 2
EXOSC4 exosome component 4
FAM60A family with sequence similarity 60, member A
FBLN1 fibulin 1
FBN2 fibrillin 2
GCLC glutamate-cysteine ligase, catalytic subunit
GLA galactosidase, alpha
GPX3 glutathione peroxidase 3
HIST1H2BD histone cluster 1, H2bd
ICAM1 intercellular adhesion molecule 1
INSM1 insulinoma-associated 1
ISYNA1 inositol-3-phosphate synthase 1
KIF14 kinesin family member 14
KRT18 keratin 18, type I
KRT5 keratin 5, type II
MEIS2 Meis homeobox 2
MMP10 matrix metallopeptidase 10
MMP7 matrix metallopeptidase 7
NOV nephroblastoma overexpressed
OLFM4 olfactomedin 4
OPN3 opsin 3
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDGFD platelet derived growth factor D
PDGFRL platelet-derived growth factor receptor-like
PEG10 paternally expressed 10
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLAU plasminogen activator, urokinase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PRAME preferentially expressed antigen in melanoma
PROM1 prominin 1
SFRP1 secreted frizzled-related protein 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TACSTD2 tumor-associated calcium signal transducer 2
TGFBI transforming growth factor, beta-induced, 68kDa
THBS2 thrombospondin 2
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1
TKTL1 transketolase-like 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS3 tensin 3
TPBG trophoblast glycoprotein
TPSAB1 tryptase alpha/beta 1
TRIM29 tripartite motif containing 29
VAV3 vav 3 guanine nucleotide exchange factor
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
BRCA1 breast cancer 1, early onset
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHL1 cell adhesion molecule L1-like
CKB creatine kinase, brain
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
DEGS1 delta(4)-desaturase, sphingolipid 1
EIF5 eukaryotic translation initiation factor 5
F13A1 coagulation factor XIII, A1 polypeptide
GLIPR1 GLI pathogenesis-related 1
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
HOPX HOP homeobox
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI44L interferon-induced protein 44-like
IFRD2 interferon-related developmental regulator 2
ISG15 ISG15 ubiquitin-like modifier
KIAA1033 KIAA1033
LAGE3 L antigen family, member 3
LMO2 LIM domain only 2 (rhombotin-like 1)
MAOA monoamine oxidase A
MAT2A methionine adenosyltransferase II, alpha
MME membrane metallo-endopeptidase
MX1 MX dynamin-like GTPase 1
NELL2 NEL-like 2 (chicken)
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
ODC1 ornithine decarboxylase 1
PDGFA platelet-derived growth factor alpha polypeptide
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PSD3 pleckstrin and Sec7 domain containing 3
PSPH phosphoserine phosphatase
PWP1 PWP1 homolog (S. cerevisiae)
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1
RGS4 regulator of G-protein signaling 4
RNASET2 ribonuclease T2
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCGB2A1 secretoglobin, family 2A, member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SPINK1 serine peptidase inhibitor, Kazal type 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STMN2 stathmin 2
TSPAN8 tetraspanin 8
ZDHHC6 zinc finger, DHHC-type containing 6
ZIC1 Zic family member 1