BRD-K78431006_crizotinib_HS578T_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

73 genes differentially expressed following the BRD-K78431006_crizotinib_HS578T_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BICC1 BicC family RNA binding protein 1
BTN3A2 butyrophilin, subfamily 3, member A2
CLDN10 claudin 10
COL6A3 collagen, type VI, alpha 3
CPE carboxypeptidase E
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FOLR1 folate receptor 1 (adult)
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GYPC glycophorin C (Gerbich blood group)
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ITM2A integral membrane protein 2A
JUN jun proto-oncogene
MSRA methionine sulfoxide reductase A
NID2 nidogen 2 (osteonidogen)
NR2F2 nuclear receptor subfamily 2, group F, member 2
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCOLCE procollagen C-endopeptidase enhancer
PEG10 paternally expressed 10
PROM1 prominin 1
RAB27A RAB27A, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
S100A9 S100 calcium binding protein A9
SCG5 secretogranin V
SGCE sarcoglycan, epsilon
SKAP2 src kinase associated phosphoprotein 2
SLC12A8 solute carrier family 12, member 8
SPATS2L spermatogenesis associated, serine-rich 2-like
SRPX sushi-repeat containing protein, X-linked
TBL1X transducin (beta)-like 1X-linked
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
AMOTL2 angiomotin like 2
BMP2 bone morphogenetic protein 2
CCL2 chemokine (C-C motif) ligand 2
CCNE2 cyclin E2
CD24 CD24 molecule
CTGF connective tissue growth factor
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
EDN1 endothelin 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FRY furry homolog (Drosophila)
GADD45B growth arrest and DNA-damage-inducible, beta
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRIA2 glutamate receptor, ionotropic, AMPA 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
KRT18 keratin 18, type I
LGALS4 lectin, galactoside-binding, soluble, 4
LMCD1 LIM and cysteine-rich domains 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
PLS1 plastin 1
SPP1 secreted phosphoprotein 1
STAP2 signal transducing adaptor family member 2
SULF1 sulfatase 1
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TM4SF1 transmembrane 4 L six family member 1
UGCG UDP-glucose ceramide glucosyltransferase