BRD-K78431006_crizotinib_HS578T_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

66 genes differentially expressed following the BRD-K78431006_crizotinib_HS578T_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD44 CD44 molecule (Indian blood group)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FBP1 fructose-1,6-bisphosphatase 1
GNB5 guanine nucleotide binding protein (G protein), beta 5
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
JUND jun D proto-oncogene
LDLR low density lipoprotein receptor
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MLPH melanophilin
MSMO1 methylsterol monooxygenase 1
NEU1 sialidase 1 (lysosomal sialidase)
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PFKL phosphofructokinase, liver
PHYH phytanoyl-CoA 2-hydroxylase
RAB38 RAB38, member RAS oncogene family
RHOB ras homolog family member B
SOAT1 sterol O-acyltransferase 1
STC1 stanniocalcin 1
TMEM97 transmembrane protein 97
TOX3 TOX high mobility group box family member 3

decreased expression

Symbol Name
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BGN biglycan
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
COL5A1 collagen, type V, alpha 1
COMP cartilage oligomeric matrix protein
CTGF connective tissue growth factor
DCN decorin
DLC1 DLC1 Rho GTPase activating protein
EIF5A eukaryotic translation initiation factor 5A
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
GBP1 guanylate binding protein 1, interferon-inducible
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GTPBP8 GTP-binding protein 8 (putative)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
LAMA3 laminin, alpha 3
LPL lipoprotein lipase
MARCKS myristoylated alanine-rich protein kinase C substrate
MSLN mesothelin
MUC16 mucin 16, cell surface associated
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PSAT1 phosphoserine aminotransferase 1
RHOBTB3 Rho-related BTB domain containing 3
S100P S100 calcium binding protein P
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SRGN serglycin
SRSF6 serine/arginine-rich splicing factor 6
TAGLN transgelin
TMEM47 transmembrane protein 47
TSPAN7 tetraspanin 7
VGLL1 vestigial-like family member 1