BRD-K78431006_crizotinib_A549_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

91 genes differentially expressed following the BRD-K78431006_crizotinib_A549_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ADIRF adipogenesis regulatory factor
APOD apolipoprotein D
AREG amphiregulin
BTG2 BTG family, member 2
CADM1 cell adhesion molecule 1
CD24 CD24 molecule
CES1 carboxylesterase 1
CPA3 carboxypeptidase A3 (mast cell)
CRYAB crystallin, alpha B
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GAA glucosidase, alpha; acid
GPR137B G protein-coupled receptor 137B
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
INSIG1 insulin induced gene 1
LSP1 lymphocyte-specific protein 1
NEBL nebulette
NOV nephroblastoma overexpressed
NRCAM neuronal cell adhesion molecule
ORAI3 ORAI calcium release-activated calcium modulator 3
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PHYH phytanoyl-CoA 2-hydroxylase
PTN pleiotrophin
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RBKS ribokinase
REEP1 receptor accessory protein 1
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SEPP1 selenoprotein P, plasma, 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SPATA20 spermatogenesis associated 20
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TP53TG1 TP53 target 1 (non-protein coding)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TTC39A tetratricopeptide repeat domain 39A
VAT1 vesicle amine transport 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
C10ORF10 chromosome 10 open reading frame 10
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C3 complement component 3
C7 complement component 7
CCNF cyclin F
CDC25A cell division cycle 25A
CDH3 cadherin 3, type 1, P-cadherin (placental)
CLDN10 claudin 10
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
CSE1L CSE1 chromosome segregation 1-like (yeast)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNM1L dynamin 1-like
EIF5A eukaryotic translation initiation factor 5A
ERGIC2 ERGIC and golgi 2
FBXO21 F-box protein 21
FGFR3 fibroblast growth factor receptor 3
HAT1 histone acetyltransferase 1
HSPH1 heat shock 105kDa/110kDa protein 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGFBP5 insulin-like growth factor binding protein 5
KIF20A kinesin family member 20A
LDHB lactate dehydrogenase B
MAPK13 mitogen-activated protein kinase 13
MEIS1 Meis homeobox 1
MGP matrix Gla protein
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDZRN3 PDZ domain containing ring finger 3
PRKD3 protein kinase D3
RGS4 regulator of G-protein signaling 4
RHOBTB3 Rho-related BTB domain containing 3
SFRP1 secreted frizzled-related protein 1
UBE2C ubiquitin-conjugating enzyme E2C
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
USP1 ubiquitin specific peptidase 1
WT1 Wilms tumor 1