BRD-K78385490_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

164 genes differentially expressed following the BRD-K78385490_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADGRF5 adhesion G protein-coupled receptor F5
ADM adrenomedullin
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG2 BTG family, member 2
C8ORF4 chromosome 8 open reading frame 4
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHIC2 cysteine-rich hydrophobic domain 2
CPM carboxypeptidase M
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DFNA5 deafness, autosomal dominant 5
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EFNA1 ephrin-A1
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ELL2 elongation factor, RNA polymerase II, 2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FHL2 four and a half LIM domains 2
FILIP1L filamin A interacting protein 1-like
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXO1 forkhead box O1
FOXO3 forkhead box O3
G0S2 G0/G1 switch 2
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GRB10 growth factor receptor-bound protein 10
GRB7 growth factor receptor-bound protein 7
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
JAG1 jagged 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF7 Kruppel-like factor 7 (ubiquitous)
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
KYNU kynureninase
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MIR22HG MIR22 host gene
MSX1 msh homeobox 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIL3 nuclear factor, interleukin 3 regulated
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
PER1 period circadian clock 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
RAB38 RAB38, member RAS oncogene family
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIK1 salt-inducible kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SMAD3 SMAD family member 3
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SPRY4 sprouty homolog 4 (Drosophila)
STC1 stanniocalcin 1
TGIF1 TGFB-induced factor homeobox 1
THBD thrombomodulin
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TMEM45A transmembrane protein 45A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDKN3 cyclin-dependent kinase inhibitor 3
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFB complement factor B
CFD complement factor D (adipsin)
CLU clusterin
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DHCR24 24-dehydrocholesterol reductase
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPHA3 EPH receptor A3
HMGB3 high mobility group box 3
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IGKV1-5 immunoglobulin kappa variable 1-5
IGLV2-23 immunoglobulin lambda variable 2-23
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
JCHAIN joining chain of multimeric IgA and IgM
KIF20A kinesin family member 20A
LEPR leptin receptor
LMNB1 lamin B1
LTF lactotransferrin
PCP4 Purkinje cell protein 4
PTTG1 pituitary tumor-transforming 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RPA2 replication protein A2, 32kDa
RRM2 ribonucleotide reductase M2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX11 SRY (sex determining region Y)-box 11
TARP TCR gamma alternate reading frame protein
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN8 tetraspanin 8
ZWINT ZW10 interacting kinetochore protein