BRD-K78278890_1-tert-butyl-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine CAL-NCGC-023_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

52 genes differentially expressed following the BRD-K78278890_1-tert-butyl-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine CAL-NCGC-023_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AHNAK AHNAK nucleoprotein
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
APOD apolipoprotein D
BASP1 brain abundant, membrane attached signal protein 1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CLCA4 chloride channel accessory 4
DDIT4 DNA-damage-inducible transcript 4
DHRS7 dehydrogenase/reductase (SDR family) member 7
ERBB3 erb-b2 receptor tyrosine kinase 3
FBLN1 fibulin 1
GBP2 guanylate binding protein 2, interferon-inducible
GCLC glutamate-cysteine ligase, catalytic subunit
GLUL glutamate-ammonia ligase
IGFBP4 insulin-like growth factor binding protein 4
IGFBP6 insulin-like growth factor binding protein 6
KIAA0753 KIAA0753
KLF4 Kruppel-like factor 4 (gut)
KRT15 keratin 15, type I
KRT18 keratin 18, type I
MKRN1 makorin ring finger protein 1
MLPH melanophilin
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
OLFM4 olfactomedin 4
PPOX protoporphyrinogen oxidase
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPL31 ribosomal protein L31
SAT1 spermidine/spermine N1-acetyltransferase 1
SELENBP1 selenium binding protein 1
SFRP1 secreted frizzled-related protein 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SPON2 spondin 2, extracellular matrix protein
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TUSC3 tumor suppressor candidate 3

decreased expression

Symbol Name
ADGRF5 adhesion G protein-coupled receptor F5
ARHGAP29 Rho GTPase activating protein 29
ATF5 activating transcription factor 5
EDN1 endothelin 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HAT1 histone acetyltransferase 1
MSLN mesothelin
PDZD2 PDZ domain containing 2
SCML1 sex comb on midleg-like 1 (Drosophila)
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMC1A structural maintenance of chromosomes 1A
TUBA4A tubulin, alpha 4a