BRD-K77908580_entinostat_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

234 genes differentially expressed following the BRD-K77908580_entinostat_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AOX1 aldehyde oxidase 1
ARHGAP29 Rho GTPase activating protein 29
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BCL2A1 BCL2-related protein A1
BHLHE40 basic helix-loop-helix family, member e40
BLVRA biliverdin reductase A
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C8ORF4 chromosome 8 open reading frame 4
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLCN4 chloride channel, voltage-sensitive 4
CLGN calmegin
CPM carboxypeptidase M
CSRP1 cysteine and glycine-rich protein 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDIT4 DNA-damage-inducible transcript 4
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP10 dual specificity phosphatase 10
DUSP6 dual specificity phosphatase 6
DYNLT3 dynein, light chain, Tctex-type 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNB2 ephrin-B2
EPHB2 EPH receptor B2
EXOSC4 exosome component 4
FABP1 fatty acid binding protein 1, liver
FABP4 fatty acid binding protein 4, adipocyte
FADS3 fatty acid desaturase 3
FAM134B family with sequence similarity 134, member B
FAR2 fatty acyl CoA reductase 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FLRT3 fibronectin leucine rich transmembrane protein 3
FOXO4 forkhead box O4
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
G0S2 G0/G1 switch 2
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATA6 GATA binding protein 6
GDF15 growth differentiation factor 15
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLIPR1 GLI pathogenesis-related 1
GREM1 gremlin 1, DAN family BMP antagonist
GSK3B glycogen synthase kinase 3 beta
GSN gelsolin
HBB hemoglobin, beta
HCAR3 hydroxycarboxylic acid receptor 3
HES1 hes family bHLH transcription factor 1
HIPK1 homeodomain interacting protein kinase 1
HIST1H2AC histone cluster 1, H2ac
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IL13RA2 interleukin 13 receptor, alpha 2
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL6 interleukin 6
KCNK1 potassium channel, two pore domain subfamily K, member 1
KIAA0922 KIAA0922
KIF5C kinesin family member 5C
KLF10 Kruppel-like factor 10
KRT6B keratin 6B, type II
L1CAM L1 cell adhesion molecule
LAMA3 laminin, alpha 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGALS4 lectin, galactoside-binding, soluble, 4
LIPG lipase, endothelial
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGST3 microsomal glutathione S-transferase 3
MMD monocyte to macrophage differentiation-associated
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MT1F metallothionein 1F
MT1H metallothionein 1H
MYO10 myosin X
MYO1B myosin IB
NDRG1 N-myc downstream regulated 1
NRCAM neuronal cell adhesion molecule
NRIP1 nuclear receptor interacting protein 1
PALLD palladin, cytoskeletal associated protein
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PEG10 paternally expressed 10
PI3 peptidase inhibitor 3, skin-derived
PLCB4 phospholipase C, beta 4
PLEKHA5 pleckstrin homology domain containing, family A member 5
POPDC3 popeye domain containing 3
PRAME preferentially expressed antigen in melanoma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS23 protease, serine, 23
PRSS3 protease, serine, 3
PTHLH parathyroid hormone-like hormone
PTN pleiotrophin
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RAB31 RAB31, member RAS oncogene family
RAP2A RAP2A, member of RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RBP1 retinol binding protein 1, cellular
RCAN1 regulator of calcineurin 1
RHOB ras homolog family member B
RHOBTB3 Rho-related BTB domain containing 3
RHOQ ras homolog family member Q
RIMS3 regulating synaptic membrane exocytosis 3
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SCPEP1 serine carboxypeptidase 1
SELENBP1 selenium binding protein 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SQRDL sulfide quinone reductase-like (yeast)
SRPX sushi-repeat containing protein, X-linked
SSX1 synovial sarcoma, X breakpoint 1
STC1 stanniocalcin 1
STOM stomatin
STXBP1 syntaxin binding protein 1
SYT1 synaptotagmin I
TIAM1 T-cell lymphoma invasion and metastasis 1
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TMEM100 transmembrane protein 100
TNC tenascin C
TOX3 TOX high mobility group box family member 3
TRIM2 tripartite motif containing 2
TSC22D1 TSC22 domain family, member 1
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
VEGFC vascular endothelial growth factor C
VLDLR very low density lipoprotein receptor
VNN1 vanin 1
WLS wntless Wnt ligand secretion mediator

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANPEP alanyl (membrane) aminopeptidase
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BPHL biphenyl hydrolase-like (serine hydrolase)
CBR3 carbonyl reductase 3
CCNB2 cyclin B2
CCND2 cyclin D2
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC25A cell division cycle 25A
CEP55 centrosomal protein 55kDa
COL6A2 collagen, type VI, alpha 2
CST6 cystatin E/M
CXCL14 chemokine (C-X-C motif) ligand 14
CYBRD1 cytochrome b reductase 1
DSP desmoplakin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ELANE elastase, neutrophil expressed
EPN2 epsin 2
ERLIN1 ER lipid raft associated 1
ESR1 estrogen receptor 1
FAM57A family with sequence similarity 57, member A
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FBL fibrillarin
FGFR3 fibroblast growth factor receptor 3
FKBP11 FK506 binding protein 11, 19 kDa
FOXC1 forkhead box C1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GOLGA8B golgin A8 family, member B
GPI glucose-6-phosphate isomerase
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HOPX HOP homeobox
HOXA10 homeobox A10
HOXB2 homeobox B2
HOXB6 homeobox B6
ICAM3 intercellular adhesion molecule 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGLJ3 immunoglobulin lambda joining 3
IGLV3-19 immunoglobulin lambda variable 3-19
JADE2 jade family PHD finger 2
KAT6B K(lysine) acetyltransferase 6B
KEAP1 kelch-like ECH-associated protein 1
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
LMNB1 lamin B1
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae)
LTF lactotransferrin
MAPK13 mitogen-activated protein kinase 13
MRPL12 mitochondrial ribosomal protein L12
MSLN mesothelin
MUC16 mucin 16, cell surface associated
MYO5C myosin VC
NUP62 nucleoporin 62kDa
PARP2 poly (ADP-ribose) polymerase 2
PITX1 paired-like homeodomain 1
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TFDP1 transcription factor Dp-1
TNS3 tensin 3
TSPYL5 TSPY-like 5
TYMS thymidylate synthetase
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
VCAN versican
XIST X inactive specific transcript (non-protein coding)
YME1L1 YME1-like 1 ATPase
ZNF91 zinc finger protein 91