BRD-K77908580_entinostat_HA1E_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-K77908580_entinostat_HA1E_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABLIM1 actin binding LIM protein 1
AHR aryl hydrocarbon receptor
AKAP12 A kinase (PRKA) anchor protein 12
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMIGO2 adhesion molecule with Ig-like domain 2
ANPEP alanyl (membrane) aminopeptidase
APOB apolipoprotein B
BCL6 B-cell CLL/lymphoma 6
BIRC3 baculoviral IAP repeat containing 3
BTG1 B-cell translocation gene 1, anti-proliferative
C3 complement component 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV2 caveolin 2
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK14 cyclin-dependent kinase 14
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLDN10 claudin 10
CRP C-reactive protein, pentraxin-related
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide
DHRS7 dehydrogenase/reductase (SDR family) member 7
DMBT1 deleted in malignant brain tumors 1
DPYSL3 dihydropyrimidinase-like 3
ENO1 enolase 1, (alpha)
EPS8 epidermal growth factor receptor pathway substrate 8
FN1 fibronectin 1
FOXO1 forkhead box O1
FYN FYN proto-oncogene, Src family tyrosine kinase
HEG1 heart development protein with EGF-like domains 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IDS iduronate 2-sulfatase
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL17RB interleukin 17 receptor B
IL32 interleukin 32
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITM2A integral membrane protein 2A
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KLF4 Kruppel-like factor 4 (gut)
KYNU kynureninase
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MET MET proto-oncogene, receptor tyrosine kinase
MLPH melanophilin
MTSS1 metastasis suppressor 1
MYH10 myosin, heavy chain 10, non-muscle
NAV2 neuron navigator 2
NLGN4X neuroligin 4, X-linked
NRIP1 nuclear receptor interacting protein 1
NT5E 5'-nucleotidase, ecto (CD73)
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLA2G16 phospholipase A2, group XVI
PLAT plasminogen activator, tissue
PLCB4 phospholipase C, beta 4
PLS1 plastin 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PTK2 protein tyrosine kinase 2
RAP2A RAP2A, member of RAS oncogene family
RBP1 retinol binding protein 1, cellular
RGS2 regulator of G-protein signaling 2
S100A10 S100 calcium binding protein A10
SCGB2A1 secretoglobin, family 2A, member 1
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A1 solute carrier family 38, member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SOX9 SRY (sex determining region Y)-box 9
STOM stomatin
SYT17 synaptotagmin XVII
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFA transforming growth factor, alpha
TGM2 transglutaminase 2
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TNIK TRAF2 and NCK interacting kinase
TPST2 tyrosylprotein sulfotransferase 2
TRIB2 tribbles pseudokinase 2
TSPAN13 tetraspanin 13
TUBB2B tubulin, beta 2B class IIb
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VDAC1 voltage-dependent anion channel 1
VNN1 vanin 1
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ADCK3 aarF domain containing kinase 3
ADI1 acireductone dioxygenase 1
BAX BCL2-associated X protein
CBR3 carbonyl reductase 3
CCDC92 coiled-coil domain containing 92
CCL2 chemokine (C-C motif) ligand 2
CTSZ cathepsin Z
CXCL11 chemokine (C-X-C motif) ligand 11
ELAVL1 ELAV like RNA binding protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM57A family with sequence similarity 57, member A
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
LMNB1 lamin B1
LRRC41 leucine rich repeat containing 41
LTF lactotransferrin
MELK maternal embryonic leucine zipper kinase
MICALL1 MICAL-like 1
PCP4 Purkinje cell protein 4
PDLIM1 PDZ and LIM domain 1
PDLIM2 PDZ and LIM domain 2 (mystique)
PLAGL1 pleiomorphic adenoma gene-like 1
PRC1 protein regulator of cytokinesis 1
PRDX2 peroxiredoxin 2
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
SHCBP1 SHC SH2-domain binding protein 1
SORBS3 sorbin and SH3 domain containing 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TIMELESS timeless circadian clock
TPM4 tropomyosin 4
TYMS thymidylate synthetase
ZBED1 zinc finger, BED-type containing 1