BRD-K77690805_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

114 genes differentially expressed following the BRD-K77690805_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARG2 arginase 2
ARL4C ADP-ribosylation factor-like 4C
ASPN asporin
ASS1 argininosuccinate synthase 1
ATP11B ATPase, class VI, type 11B
CD40 CD40 molecule, TNF receptor superfamily member 5
CD93 CD93 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL8A2 collagen, type VIII, alpha 2
CPE carboxypeptidase E
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPT dermatopontin
DPYSL3 dihydropyrimidinase-like 3
EML1 echinoderm microtubule associated protein like 1
EPAS1 endothelial PAS domain protein 1
ETV5 ets variant 5
FILIP1L filamin A interacting protein 1-like
G0S2 G0/G1 switch 2
GPNMB glycoprotein (transmembrane) nmb
GRB7 growth factor receptor-bound protein 7
GUCY1B3 guanylate cyclase 1, soluble, beta 3
GULP1 GULP, engulfment adaptor PTB domain containing 1
HADH hydroxyacyl-CoA dehydrogenase
HDAC9 histone deacetylase 9
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IDO1 indoleamine 2,3-dioxygenase 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGL immunoglobulin lambda locus
KCNK3 potassium channel, two pore domain subfamily K, member 3
LMO3 LIM domain only 3 (rhombotin-like 2)
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
MSLN mesothelin
PCLO piccolo presynaptic cytomatrix protein
PDZD2 PDZ domain containing 2
PECAM1 platelet/endothelial cell adhesion molecule 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PPOX protoporphyrinogen oxidase
PRKCI protein kinase C, iota
PRUNE2 prune homolog 2 (Drosophila)
PTN pleiotrophin
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SNX7 sorting nexin 7
SPINT1 serine peptidase inhibitor, Kunitz type 1
ST18 suppression of tumorigenicity 18, zinc finger
STON1 stonin 1
TCF4 transcription factor 4
TES testin LIM domain protein
TMEM165 transmembrane protein 165
TMSB15A thymosin beta 15a
TSPAN12 tetraspanin 12
TUBA1A tubulin, alpha 1a
WARS tryptophanyl-tRNA synthetase
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
AHNAK AHNAK nucleoprotein
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AQP3 aquaporin 3 (Gill blood group)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
BMI1 BMI1 proto-oncogene, polycomb ring finger
C2CD2 C2 calcium-dependent domain containing 2
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
COMMD3 COMM domain containing 3
CTSH cathepsin H
CXCL12 chemokine (C-X-C motif) ligand 12
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
F12 coagulation factor XII (Hageman factor)
F3 coagulation factor III (thromboplastin, tissue factor)
FABP1 fatty acid binding protein 1, liver
FGF13 fibroblast growth factor 13
HOXC10 homeobox C10
HOXC6 homeobox C6
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IL6ST interleukin 6 signal transducer
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
LTF lactotransferrin
LY6D lymphocyte antigen 6 complex, locus D
MAMLD1 mastermind-like domain containing 1
MARCKS myristoylated alanine-rich protein kinase C substrate
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MGP matrix Gla protein
MMP12 matrix metallopeptidase 12
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PLS3 plastin 3
PRAME preferentially expressed antigen in melanoma
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RAB14 RAB14, member RAS oncogene family
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLPI secretory leukocyte peptidase inhibitor
SPATS2L spermatogenesis associated, serine-rich 2-like
STK17A serine/threonine kinase 17a
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
THOC2 THO complex 2
TLR4 toll-like receptor 4
TMED2 transmembrane emp24 domain trafficking protein 2
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TSPAN8 tetraspanin 8
UBE2A ubiquitin-conjugating enzyme E2A
ZNF586 zinc finger protein 586