BRD-K77681376_2-morpholino-N-((4-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

120 genes differentially expressed following the BRD-K77681376_2-morpholino-N-((4-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACP5 acid phosphatase 5, tartrate resistant
AEBP1 AE binding protein 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANXA4 annexin A4
AQP9 aquaporin 9
ATF3 activating transcription factor 3
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BSG basigin (Ok blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CECR1 cat eye syndrome chromosome region, candidate 1
CFB complement factor B
CLIC5 chloride intracellular channel 5
COL4A5 collagen, type IV, alpha 5
CSTA cystatin A (stefin A)
CXCL2 chemokine (C-X-C motif) ligand 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DUSP1 dual specificity phosphatase 1
EXPH5 exophilin 5
FILIP1L filamin A interacting protein 1-like
FLT1 fms-related tyrosine kinase 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
H1FX H1 histone family, member X
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
JAG1 jagged 1
JUN jun proto-oncogene
MMP9 matrix metallopeptidase 9
MSMB microseminoprotein, beta-
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUCB1 nucleobindin 1
ORM1 orosomucoid 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PYCARD PYD and CARD domain containing
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS1 regulator of G-protein signaling 1
RGS5 regulator of G-protein signaling 5
RNASE6 ribonuclease, RNase A family, k6
RPS4Y1 ribosomal protein S4, Y-linked 1
RTN2 reticulon 2
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELENBP1 selenium binding protein 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SPARCL1 SPARC-like 1 (hevin)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TUBA1A tubulin, alpha 1a
UBE2J1 ubiquitin-conjugating enzyme E2, J1
VTCN1 V-set domain containing T cell activation inhibitor 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ARMCX6 armadillo repeat containing, X-linked 6
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDK7 cyclin-dependent kinase 7
CHERP calcium homeostasis endoplasmic reticulum protein
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
FABP7 fatty acid binding protein 7, brain
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
GCH1 GTP cyclohydrolase 1
GLDC glycine dehydrogenase (decarboxylating)
GOLGA8A golgin A8 family, member A
HOMER1 homer scaffolding protein 1
HOXA1 homeobox A1
HOXC10 homeobox C10
HOXC6 homeobox C6
IGFBP4 insulin-like growth factor binding protein 4
JMJD6 jumonji domain containing 6
KRT7 keratin 7, type II
MARCKS myristoylated alanine-rich protein kinase C substrate
MICB MHC class I polypeptide-related sequence B
N4BP2L2 NEDD4 binding protein 2-like 2
NRN1 neuritin 1
PDGFA platelet-derived growth factor alpha polypeptide
PFKP phosphofructokinase, platelet
PLK1 polo-like kinase 1
PPIF peptidylprolyl isomerase F
PSMG2 proteasome (prosome, macropain) assembly chaperone 2
RAE1 ribonucleic acid export 1
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RNMT RNA (guanine-7-) methyltransferase
RPS11 ribosomal protein S11
SACS sacsin molecular chaperone
SCGB2A2 secretoglobin, family 2A, member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMAD3 SMAD family member 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBP TATA box binding protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF3 trefoil factor 3 (intestinal)
THBS4 thrombospondin 4
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNPO1 transportin 1
WEE1 WEE1 G2 checkpoint kinase
ZCCHC8 zinc finger, CCHC domain containing 8