BRD-K77681376_2-morpholino-N-((4-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

131 genes differentially expressed following the BRD-K77681376_2-morpholino-N-((4-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD17A abhydrolase domain containing 17A
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANXA1 annexin A1
APOE apolipoprotein E
CAPN2 calpain 2, (m/II) large subunit
CCL20 chemokine (C-C motif) ligand 20
CD14 CD14 molecule
CD9 CD9 molecule
COL1A2 collagen, type I, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CRP C-reactive protein, pentraxin-related
CSTA cystatin A (stefin A)
CTSB cathepsin B
CXCL8 chemokine (C-X-C motif) ligand 8
DCN decorin
DPYD dihydropyrimidine dehydrogenase
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
GADD45B growth arrest and DNA-damage-inducible, beta
GPX1 glutathione peroxidase 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LPAR6 lysophosphatidic acid receptor 6
LYZ lysozyme
MAOA monoamine oxidase A
MDFIC MyoD family inhibitor domain containing
MT1M metallothionein 1M
MYC v-myc avian myelocytomatosis viral oncogene homolog
OLFM4 olfactomedin 4
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TFPI2 tissue factor pathway inhibitor 2
TMEM259 transmembrane protein 259
TMEM45A transmembrane protein 45A
TMEM47 transmembrane protein 47
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAN versican
VIM vimentin
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ADGRG2 adhesion G protein-coupled receptor G2
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR1C3 aldo-keto reductase family 1, member C3
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BLCAP bladder cancer associated protein
BRPF1 bromodomain and PHD finger containing, 1
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHD1 chromodomain helicase DNA binding protein 1
CHIC2 cysteine-rich hydrophobic domain 2
CHPT1 choline phosphotransferase 1
CHSY1 chondroitin sulfate synthase 1
CREBBP CREB binding protein
DBF4 DBF4 zinc finger
DICER1 dicer 1, ribonuclease type III
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
FAM102A family with sequence similarity 102, member A
FOXJ3 forkhead box J3
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
MGLL monoglyceride lipase
MTF2 metal response element binding transcription factor 2
NCOA3 nuclear receptor coactivator 3
NET1 neuroepithelial cell transforming 1
NOTCH2NL notch 2 N-terminal like
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NXT1 nuclear transport factor 2-like export factor 1
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PEG10 paternally expressed 10
PFKP phosphofructokinase, platelet
PLAGL2 pleiomorphic adenoma gene-like 2
PPAP2B phosphatidic acid phosphatase type 2B
PPIF peptidylprolyl isomerase F
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAD9A RAD9 homolog A (S. pombe)
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RHOBTB3 Rho-related BTB domain containing 3
RPS11 ribosomal protein S11
SCAF8 SR-related CTD-associated factor 8
SERTAD2 SERTA domain containing 2
SETD5 SET domain containing 5
SLC38A1 solute carrier family 38, member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBP TATA box binding protein
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNPO1 transportin 1
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TXLNA taxilin alpha
UBXN7 UBX domain protein 7
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
ZBED5 zinc finger, BED-type containing 5
ZCCHC2 zinc finger, CCHC domain containing 2
ZMYM2 zinc finger, MYM-type 2
ZNF131 zinc finger protein 131