BRD-K77681376_2-morpholino-N-((4-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

259 genes differentially expressed following the BRD-K77681376_2-morpholino-N-((4-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADD3 adducin 3 (gamma)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANGPTL2 angiopoietin-like 2
ANXA1 annexin A1
AQP1 aquaporin 1 (Colton blood group)
AQP9 aquaporin 9
ASGR2 asialoglycoprotein receptor 2
ASPN asporin
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CADM1 cell adhesion molecule 1
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD93 CD93 molecule
CHN2 chimerin 2
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLC Charcot-Leyden crystal galectin
CLEC2B C-type lectin domain family 2, member B
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
COL5A2 collagen, type V, alpha 2
CPA3 carboxypeptidase A3 (mast cell)
CTGF connective tissue growth factor
CXADR coxsackie virus and adenovirus receptor
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
ECM1 extracellular matrix protein 1
ERBB4 erb-b2 receptor tyrosine kinase 4
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM129A family with sequence similarity 129, member A
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FOXF1 forkhead box F1
FST follistatin
G0S2 G0/G1 switch 2
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GREM1 gremlin 1, DAN family BMP antagonist
HES1 hes family bHLH transcription factor 1
HOPX HOP homeobox
HP haptoglobin
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IL1R1 interleukin 1 receptor, type I
INHBA inhibin, beta A
ISG15 ISG15 ubiquitin-like modifier
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LRRC17 leucine rich repeat containing 17
MAOA monoamine oxidase A
MEF2C myocyte enhancer factor 2C
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MT1E metallothionein 1E
MT1M metallothionein 1M
MX1 MX dynamin-like GTPase 1
MXRA5 matrix-remodelling associated 5
NQO2 NAD(P)H dehydrogenase, quinone 2
NRGN neurogranin (protein kinase C substrate, RC3)
ORM1 orosomucoid 1
PAX6 paired box 6
PCDH7 protocadherin 7
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK1 proprotein convertase subtilisin/kexin type 1
PDGFC platelet derived growth factor C
PLAU plasminogen activator, urokinase
PLVAP plasmalemma vesicle associated protein
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRO protein tyrosine phosphatase, receptor type, O
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
SST somatostatin
STC1 stanniocalcin 1
SULF1 sulfatase 1
TCF4 transcription factor 4
TF transferrin
THBS1 thrombospondin 1
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TMEM158 transmembrane protein 158 (gene/pseudogene)
UBQLN2 ubiquilin 2
UBR2 ubiquitin protein ligase E3 component n-recognin 2
VEGFA vascular endothelial growth factor A
VNN1 vanin 1
VSNL1 visinin-like 1
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
ZFPM2 zinc finger protein, FOG family member 2
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACLY ATP citrate lyase
ACTN1 actinin, alpha 1
AGR2 anterior gradient 2
AMD1 adenosylmethionine decarboxylase 1
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARMCX6 armadillo repeat containing, X-linked 6
ARMT1 acidic residue methyltransferase 1
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa
ATMIN ATM interactor
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BCAS3 breast carcinoma amplified sequence 3
BUB3 BUB3 mitotic checkpoint protein
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CD164 CD164 molecule, sialomucin
CD24 CD24 molecule
CD81 CD81 molecule
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDKN3 cyclin-dependent kinase inhibitor 3
CHERP calcium homeostasis endoplasmic reticulum protein
CHPT1 choline phosphotransferase 1
CLU clusterin
CNIH1 cornichon family AMPA receptor auxiliary protein 1
COIL coilin
CTTN cortactin
CXCL12 chemokine (C-X-C motif) ligand 12
CYC1 cytochrome c-1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FHL2 four and a half LIM domains 2
FOXJ3 forkhead box J3
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GDF15 growth differentiation factor 15
GLOD4 glyoxalase domain containing 4
GRWD1 glutamate-rich WD repeat containing 1
GYG1 glycogenin 1
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP4 insulin-like growth factor binding protein 4
IRS2 insulin receptor substrate 2
KDM5D lysine (K)-specific demethylase 5D
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT10 keratin 10, type I
KRT7 keratin 7, type II
KRT81 keratin 81, type II
KYNU kynureninase
LITAF lipopolysaccharide-induced TNF factor
LTF lactotransferrin
LXN latexin
LY6E lymphocyte antigen 6 complex, locus E
MAGED1 melanoma antigen family D1
MARCKSL1 MARCKS-like 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLPH melanophilin
NBN nibrin
NCOA3 nuclear receptor coactivator 3
NNMT nicotinamide N-methyltransferase
NPY1R neuropeptide Y receptor Y1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
OPN3 opsin 3
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PFKP phosphofructokinase, platelet
PIR pirin (iron-binding nuclear protein)
PNMA1 paraneoplastic Ma antigen 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PRSS23 protease, serine, 23
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGES prostaglandin E synthase
PUF60 poly-U binding splicing factor 60KDa
RAB22A RAB22A, member RAS oncogene family
RAD51C RAD51 paralog C
RAE1 ribonucleic acid export 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RNMT RNA (guanine-7-) methyltransferase
RNPS1 RNA binding protein S1, serine-rich domain
RPL36AL ribosomal protein L36a-like
RPS11 ribosomal protein S11
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLIRP SRA stem-loop interacting RNA binding protein
SNRPE small nuclear ribonucleoprotein polypeptide E
SPATA20 spermatogenesis associated 20
SPDEF SAM pointed domain containing ETS transcription factor
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBL1X transducin (beta)-like 1X-linked
TBP TATA box binding protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TES testin LIM domain protein
TFAM transcription factor A, mitochondrial
TFB2M transcription factor B2, mitochondrial
TFF1 trefoil factor 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM251 transmembrane protein 251
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIM16 tripartite motif containing 16
TRIM28 tripartite motif containing 28
TRIM37 tripartite motif containing 37
TSKU tsukushi, small leucine rich proteoglycan
TSPAN13 tetraspanin 13
TSPYL5 TSPY-like 5
TUBD1 tubulin, delta 1
TXLNA taxilin alpha
UBE2S ubiquitin-conjugating enzyme E2S
UBL3 ubiquitin-like 3
UGCG UDP-glucose ceramide glucosyltransferase
USP22 ubiquitin specific peptidase 22
XBP1 X-box binding protein 1
ZMYM2 zinc finger, MYM-type 2