BRD-K77681376_2-morpholino-N-((4-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

214 genes differentially expressed following the BRD-K77681376_2-morpholino-N-((4-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOT7 acyl-CoA thioesterase 7
ACP5 acid phosphatase 5, tartrate resistant
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
AEBP1 AE binding protein 1
APLP2 amyloid beta (A4) precursor-like protein 2
ASPN asporin
ATF3 activating transcription factor 3
C10ORF10 chromosome 10 open reading frame 10
CD38 CD38 molecule
CD99 CD99 molecule
CECR1 cat eye syndrome chromosome region, candidate 1
CKB creatine kinase, brain
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CTSZ cathepsin Z
DCN decorin
DNM1 dynamin 1
DNTT DNA nucleotidylexotransferase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
EPCAM epithelial cell adhesion molecule
F11R F11 receptor
FLOT1 flotillin 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOS FBJ murine osteosarcoma viral oncogene homolog
GADD45B growth arrest and DNA-damage-inducible, beta
HAPLN1 hyaluronan and proteoglycan link protein 1
HES1 hes family bHLH transcription factor 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IER3 immediate early response 3
IFITM3 interferon induced transmembrane protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INHBA inhibin, beta A
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIAA0226L KIAA0226-like
LEF1 lymphoid enhancer-binding factor 1
LRRC15 leucine rich repeat containing 15
LTA4H leukotriene A4 hydrolase
LUM lumican
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MFAP2 microfibrillar-associated protein 2
MME membrane metallo-endopeptidase
MMP11 matrix metallopeptidase 11
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NREP neuronal regeneration related protein
PFKM phosphofructokinase, muscle
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PSPH phosphoserine phosphatase
RNF130 ring finger protein 130
RPRD1A regulation of nuclear pre-mRNA domain containing 1A
SCARB2 scavenger receptor class B, member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SORD sorbitol dehydrogenase
STS steroid sulfatase (microsomal), isozyme S
SULF1 sulfatase 1
TCF4 transcription factor 4
THY1 Thy-1 cell surface antigen
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
TPD52 tumor protein D52
TUSC3 tumor suppressor candidate 3

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ADIPOQ adiponectin, C1Q and collagen domain containing
ADNP activity-dependent neuroprotector homeobox
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANXA10 annexin A10
ARPC5L actin related protein 2/3 complex, subunit 5-like
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
BMP4 bone morphogenetic protein 4
C10ORF2 chromosome 10 open reading frame 2
C14ORF169 chromosome 14 open reading frame 169
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CCNF cyclin F
CDC123 cell division cycle 123
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHERP calcium homeostasis endoplasmic reticulum protein
CKS2 CDC28 protein kinase regulatory subunit 2
DBF4 DBF4 zinc finger
DCLRE1C DNA cross-link repair 1C
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP6 dual specificity phosphatase 6
EED embryonic ectoderm development
ELF4 E74-like factor 4 (ets domain transcription factor)
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FAM208B family with sequence similarity 208, member B
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA2 GATA binding protein 2
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GPX2 glutathione peroxidase 2
GRWD1 glutamate-rich WD repeat containing 1
GSPT2 G1 to S phase transition 2
GTPBP4 GTP binding protein 4
HNMT histamine N-methyltransferase
HOMER1 homer scaffolding protein 1
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA14 heat shock 70kDa protein 14
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP4 insulin-like growth factor binding protein 4
INPP1 inositol polyphosphate-1-phosphatase
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
IST1 increased sodium tolerance 1 homolog (yeast)
JMJD6 jumonji domain containing 6
KANK1 KN motif and ankyrin repeat domains 1
KIAA0485 uncharacterized LOC57235
KIN Kin17 DNA and RNA binding protein
KLHL21 kelch-like family member 21
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LARP4B La ribonucleoprotein domain family, member 4B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM10 minichromosome maintenance complex component 10
MED17 mediator complex subunit 17
METTL18 methyltransferase like 18
MGLL monoglyceride lipase
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit
NET1 neuroepithelial cell transforming 1
NFIB nuclear factor I/B
NGDN neuroguidin, EIF4E binding protein
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NOTCH2NL notch 2 N-terminal like
NQO1 NAD(P)H dehydrogenase, quinone 1
NRIP1 nuclear receptor interacting protein 1
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1
NUP50 nucleoporin 50kDa
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
PCNA proliferating cell nuclear antigen
PELO pelota homolog (Drosophila)
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
PPARG peroxisome proliferator-activated receptor gamma
PPIF peptidylprolyl isomerase F
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
RAE1 ribonucleic acid export 1
RBM15 RNA binding motif protein 15
RGS2 regulator of G-protein signaling 2
RNF139 ring finger protein 139
RNF4 ring finger protein 4
RPP38 ribonuclease P/MRP 38kDa subunit
S100P S100 calcium binding protein P
SACS sacsin molecular chaperone
SASH1 SAM and SH3 domain containing 1
SCAF8 SR-related CTD-associated factor 8
SEPHS1 selenophosphate synthetase 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFRP1 secreted frizzled-related protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TCERG1 transcription elongation regulator 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TEX10 testis expressed 10
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIMP4 TIMP metallopeptidase inhibitor 4
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TIPIN TIMELESS interacting protein
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TMEM11 transmembrane protein 11
TNPO1 transportin 1
TOB2 transducer of ERBB2, 2
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TXLNA taxilin alpha
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UMPS uridine monophosphate synthetase
WAPAL wings apart-like homolog (Drosophila)
WEE1 WEE1 G2 checkpoint kinase
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF22 zinc finger protein 22