BRD-K77681376_2-morpholino-N-((4-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

219 genes differentially expressed following the BRD-K77681376_2-morpholino-N-((4-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AEBP1 AE binding protein 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AQP1 aquaporin 1 (Colton blood group)
C10ORF10 chromosome 10 open reading frame 10
CCND2 cyclin D2
CD36 CD36 molecule (thrombospondin receptor)
CD59 CD59 molecule, complement regulatory protein
CD99 CD99 molecule
CFB complement factor B
CFH complement factor H
CLDN3 claudin 3
CXCL10 chemokine (C-X-C motif) ligand 10
DYNLT3 dynein, light chain, Tctex-type 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
FHL1 four and a half LIM domains 1
FLT1 fms-related tyrosine kinase 1
GADD45B growth arrest and DNA-damage-inducible, beta
GLUL glutamate-ammonia ligase
GNG10 guanine nucleotide binding protein (G protein), gamma 10
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JUN jun proto-oncogene
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA0226L KIAA0226-like
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MGP matrix Gla protein
NEBL nebulette
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLVAP plasmalemma vesicle associated protein
POSTN periostin, osteoblast specific factor
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RCAN1 regulator of calcineurin 1
RGS5 regulator of G-protein signaling 5
SCG2 secretogranin II
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SNX10 sorting nexin 10
STC1 stanniocalcin 1
SULF1 sulfatase 1
THBS2 thrombospondin 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ARID4B AT rich interactive domain 4B (RBP1-like)
ATMIN ATM interactor
AURKA aurora kinase A
BAG5 BCL2-associated athanogene 5
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BIRC2 baculoviral IAP repeat containing 2
BLCAP bladder cancer associated protein
BTBD3 BTB (POZ) domain containing 3
CANT1 calcium activated nucleotidase 1
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDCA4 cell division cycle associated 4
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CHERP calcium homeostasis endoplasmic reticulum protein
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CHSY1 chondroitin sulfate synthase 1
CKAP2 cytoskeleton associated protein 2
COIL coilin
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CRNKL1 crooked neck pre-mRNA splicing factor 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
DBF4 DBF4 zinc finger
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
FAM208B family with sequence similarity 208, member B
FASTKD5 FAST kinase domains 5
FEM1B fem-1 homolog b (C. elegans)
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GEMIN4 gem (nuclear organelle) associated protein 4
GGNBP2 gametogenetin binding protein 2
GSPT2 G1 to S phase transition 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
INPP1 inositol polyphosphate-1-phosphatase
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
IST1 increased sodium tolerance 1 homolog (yeast)
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KAT6A K(lysine) acetyltransferase 6A
KDM5B lysine (K)-specific demethylase 5B
KEAP1 kelch-like ECH-associated protein 1
KIN Kin17 DNA and RNA binding protein
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAK16 MAK16 homolog (S. cerevisiae)
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MBNL2 muscleblind-like splicing regulator 2
MED13 mediator complex subunit 13
MED17 mediator complex subunit 17
MFSD5 major facilitator superfamily domain containing 5
MRFAP1L1 Morf4 family associated protein 1-like 1
MSH6 mutS homolog 6
MTF2 metal response element binding transcription factor 2
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NCK1 NCK adaptor protein 1
NET1 neuroepithelial cell transforming 1
NGDN neuroguidin, EIF4E binding protein
NOL11 nucleolar protein 11
NRIP1 nuclear receptor interacting protein 1
NUP153 nucleoporin 153kDa
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDS5B PDS5 cohesin associated factor B
PDZD8 PDZ domain containing 8
PLAGL2 pleiomorphic adenoma gene-like 2
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
POLR1C polymerase (RNA) I polypeptide C, 30kDa
POU2AF1 POU class 2 associating factor 1
PPIF peptidylprolyl isomerase F
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRPF4B pre-mRNA processing factor 4B
PSMG2 proteasome (prosome, macropain) assembly chaperone 2
PUF60 poly-U binding splicing factor 60KDa
RAE1 ribonucleic acid export 1
RANBP2 RAN binding protein 2
RANBP6 RAN binding protein 6
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RBM15 RNA binding motif protein 15
RBM39 RNA binding motif protein 39
RHOF ras homolog family member F (in filopodia)
RNF6 ring finger protein (C3H2C3 type) 6
RNMT RNA (guanine-7-) methyltransferase
RPP38 ribonuclease P/MRP 38kDa subunit
RREB1 ras responsive element binding protein 1
SACS sacsin molecular chaperone
SCAF8 SR-related CTD-associated factor 8
SIAH2 siah E3 ubiquitin protein ligase 2
SIRT1 sirtuin 1
SIX1 SIX homeobox 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A2 solute carrier family 38, member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SMG8 SMG8 nonsense mediated mRNA decay factor
STIL SCL/TAL1 interrupting locus
STK17A serine/threonine kinase 17a
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBC1D4 TBC1 domain family, member 4
TBP TATA box binding protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TEFM transcription elongation factor, mitochondrial
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFB2M transcription factor B2, mitochondrial
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TUBB2A tubulin, beta 2A class IIa
TXLNA taxilin alpha
TXNDC9 thioredoxin domain containing 9
UMPS uridine monophosphate synthetase
USP1 ubiquitin specific peptidase 1
USP6NL USP6 N-terminal like
WAC WW domain containing adaptor with coiled-coil
WAPAL wings apart-like homolog (Drosophila)
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
YTHDC1 YTH domain containing 1
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3
ZBTB11 zinc finger and BTB domain containing 11
ZNF146 zinc finger protein 146
ZNF451 zinc finger protein 451