BRD-K77681376_2-morpholino-N-((4-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

317 genes differentially expressed following the BRD-K77681376_2-morpholino-N-((4-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AQP3 aquaporin 3 (Gill blood group)
ATF3 activating transcription factor 3
BCAP31 B-cell receptor-associated protein 31
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CD177 CD177 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD47 CD47 molecule
CD9 CD9 molecule
CDC42 cell division cycle 42
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CETN2 centrin, EF-hand protein, 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN3 claudin 3
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
CRABP2 cellular retinoic acid binding protein 2
CRYAB crystallin, alpha B
CXCL2 chemokine (C-X-C motif) ligand 2
DHRS3 dehydrogenase/reductase (SDR family) member 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
ENO1 enolase 1, (alpha)
FABP4 fatty acid binding protein 4, adipocyte
FCGBP Fc fragment of IgG binding protein
FOS FBJ murine osteosarcoma viral oncogene homolog
GAS6 growth arrest-specific 6
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPM6A glycoprotein M6A
GPX3 glutathione peroxidase 3
GSN gelsolin
GUK1 guanylate kinase 1
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI6 interferon, alpha-inducible protein 6
IFT57 intraflagellar transport 57
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IL7R interleukin 7 receptor
ISG15 ISG15 ubiquitin-like modifier
KRT19 keratin 19, type I
KRT4 keratin 4, type II
KRT5 keratin 5, type II
LPL lipoprotein lipase
LTB lymphotoxin beta (TNF superfamily, member 3)
MAOA monoamine oxidase A
MAP7 microtubule-associated protein 7
MFAP2 microfibrillar-associated protein 2
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
NEBL nebulette
NES nestin
NRP1 neuropilin 1
OLFM4 olfactomedin 4
PAM peptidylglycine alpha-amidating monooxygenase
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM3 PDZ and LIM domain 3
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLBD1 phospholipase B domain containing 1
POSTN periostin, osteoblast specific factor
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS16 regulator of G-protein signaling 16
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCPEP1 serine carboxypeptidase 1
SDC1 syndecan 1
SELENBP1 selenium binding protein 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
ST14 suppression of tumorigenicity 14 (colon carcinoma)
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TM4SF1 transmembrane 4 L six family member 1
TMEM176B transmembrane protein 176B
TPM2 tropomyosin 2 (beta)
TUSC3 tumor suppressor candidate 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VSIG4 V-set and immunoglobulin domain containing 4
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACBD3 acyl-CoA binding domain containing 3
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID1A AT rich interactive domain 1A (SWI-like)
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4A ADP-ribosylation factor-like 4A
ARL4C ADP-ribosylation factor-like 4C
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BASP1 brain abundant, membrane attached signal protein 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCL10 B-cell CLL/lymphoma 10
BCOR BCL6 corepressor
C14ORF169 chromosome 14 open reading frame 169
C6ORF62 chromosome 6 open reading frame 62
CALB1 calbindin 1, 28kDa
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CCNF cyclin F
CDC14B cell division cycle 14B
CDC25A cell division cycle 25A
CDC5L cell division cycle 5-like
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2AIP CDKN2A interacting protein
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CHERP calcium homeostasis endoplasmic reticulum protein
CHSY1 chondroitin sulfate synthase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CNOT4 CCR4-NOT transcription complex, subunit 4
COIL coilin
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
DBF4 DBF4 zinc finger
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EIF4B eukaryotic translation initiation factor 4B
EIF5 eukaryotic translation initiation factor 5
ELF1 E74-like factor 1 (ets domain transcription factor)
FADD Fas (TNFRSF6)-associated via death domain
FAM46C family with sequence similarity 46, member C
FASTKD5 FAST kinase domains 5
FBXO11 F-box protein 11
FEM1B fem-1 homolog b (C. elegans)
FOSL1 FOS-like antigen 1
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GCH1 GTP cyclohydrolase 1
GOSR1 golgi SNAP receptor complex member 1
GPATCH8 G patch domain containing 8
GREB1 growth regulation by estrogen in breast cancer 1
GRWD1 glutamate-rich WD repeat containing 1
GSPT2 G1 to S phase transition 2
GTF2B general transcription factor IIB
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa
H2AFX H2A histone family, member X
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
ING3 inhibitor of growth family, member 3
INTS5 integrator complex subunit 5
IRS2 insulin receptor substrate 2
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
IST1 increased sodium tolerance 1 homolog (yeast)
JADE1 jade family PHD finger 1
JADE2 jade family PHD finger 2
JARID2 jumonji, AT rich interactive domain 2
JMJD6 jumonji domain containing 6
KANK1 KN motif and ankyrin repeat domains 1
KDM2A lysine (K)-specific demethylase 2A
KDM5B lysine (K)-specific demethylase 5B
KEAP1 kelch-like ECH-associated protein 1
KIAA0101 KIAA0101
KIF2C kinesin family member 2C
KIF5C kinesin family member 5C
KLF4 Kruppel-like factor 4 (gut)
LCMT2 leucine carboxyl methyltransferase 2
LIPT1 lipoyltransferase 1
LMO2 LIM domain only 2 (rhombotin-like 1)
LRIF1 ligand dependent nuclear receptor interacting factor 1
MAD2L1BP MAD2L1 binding protein
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MCL1 myeloid cell leukemia 1
MED13 mediator complex subunit 13
MEPCE methylphosphate capping enzyme
MFAP1 microfibrillar-associated protein 1
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MID1IP1 MID1 interacting protein 1
MRPS30 mitochondrial ribosomal protein S30
MSH6 mutS homolog 6
MTF2 metal response element binding transcription factor 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCK1 NCK adaptor protein 1
NET1 neuroepithelial cell transforming 1
NFE2L2 nuclear factor, erythroid 2-like 2
NGDN neuroguidin, EIF4E binding protein
NKX3-1 NK3 homeobox 1
NPAT nuclear protein, ataxia-telangiectasia locus
NPY1R neuropeptide Y receptor Y1
NRBF2 nuclear receptor binding factor 2
NUP153 nucleoporin 153kDa
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NUSAP1 nucleolar and spindle associated protein 1
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCF11 PCF11 cleavage and polyadenylation factor subunit
PELO pelota homolog (Drosophila)
PGRMC2 progesterone receptor membrane component 2
PHF20 PHD finger protein 20
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PLAGL2 pleiomorphic adenoma gene-like 2
PNN pinin, desmosome associated protein
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PPIF peptidylprolyl isomerase F
PPIG peptidylprolyl isomerase G (cyclophilin G)
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRRC2C proline-rich coiled-coil 2C
PTRH2 peptidyl-tRNA hydrolase 2
RAB14 RAB14, member RAS oncogene family
RAE1 ribonucleic acid export 1
RANBP2 RAN binding protein 2
RANBP6 RAN binding protein 6
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RBM15 RNA binding motif protein 15
RBM39 RNA binding motif protein 39
RBM48 RNA binding motif protein 48
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RCOR1 REST corepressor 1
REST RE1-silencing transcription factor
RGS2 regulator of G-protein signaling 2
RLF rearranged L-myc fusion
RNF111 ring finger protein 111
RPL27A ribosomal protein L27a
RPL36AL ribosomal protein L36a-like
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSRC2 arginine/serine-rich coiled-coil 2
RYBP RING1 and YY1 binding protein
SACS sacsin molecular chaperone
SALL1 spalt-like transcription factor 1
SCAF8 SR-related CTD-associated factor 8
SEC24B SEC24 family member B
SECISBP2L SECIS binding protein 2-like
SIRT1 sirtuin 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SMG8 SMG8 nonsense mediated mRNA decay factor
SNRK SNF related kinase
SON SON DNA binding protein
SPATA5L1 spermatogenesis associated 5-like 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNJ2 synaptojanin 2
TBP TATA box binding protein
TCAF1 TRPM8 channel-associated factor 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TEFM transcription elongation factor, mitochondrial
TFB2M transcription factor B2, mitochondrial
TGIF1 TGFB-induced factor homeobox 1
THUMPD1 THUMP domain containing 1
TICAM1 toll-like receptor adaptor molecule 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM11 transmembrane protein 11
TNPO1 transportin 1
TOB2 transducer of ERBB2, 2
TP53BP2 tumor protein p53 binding protein 2
TRIM32 tripartite motif containing 32
TSC22D2 TSC22 domain family, member 2
UGCG UDP-glucose ceramide glucosyltransferase
UMPS uridine monophosphate synthetase
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VAV3 vav 3 guanine nucleotide exchange factor
WAPAL wings apart-like homolog (Drosophila)
WDR82 WD repeat domain 82
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
XBP1 X-box binding protein 1
YTHDC1 YTH domain containing 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3
ZBTB11 zinc finger and BTB domain containing 11
ZC3H4 zinc finger CCCH-type containing 4
ZCCHC2 zinc finger, CCHC domain containing 2
ZCCHC8 zinc finger, CCHC domain containing 8
ZNF189 zinc finger protein 189
ZNF217 zinc finger protein 217
ZNF267 zinc finger protein 267
ZNF281 zinc finger protein 281
ZNF330 zinc finger protein 330
ZNF443 zinc finger protein 443
ZNF451 zinc finger protein 451