BRD-K77681376_2-morpholino-N-((4-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

229 genes differentially expressed following the BRD-K77681376_2-morpholino-N-((4-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRF5 adhesion G protein-coupled receptor F5
ADIRF adipogenesis regulatory factor
AEBP1 AE binding protein 1
ALCAM activated leukocyte cell adhesion molecule
ALOX5 arachidonate 5-lipoxygenase
ANPEP alanyl (membrane) aminopeptidase
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AQP1 aquaporin 1 (Colton blood group)
AQP9 aquaporin 9
ARHGAP29 Rho GTPase activating protein 29
ASPN asporin
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BGN biglycan
C10ORF10 chromosome 10 open reading frame 10
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL20 chemokine (C-C motif) ligand 20
CD47 CD47 molecule
CD9 CD9 molecule
CD93 CD93 molecule
CFB complement factor B
CFH complement factor H
CHN2 chimerin 2
CLIC5 chloride intracellular channel 5
CLIP3 CAP-GLY domain containing linker protein 3
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COLEC12 collectin sub-family member 12
COMP cartilage oligomeric matrix protein
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CRP C-reactive protein, pentraxin-related
CXCL2 chemokine (C-X-C motif) ligand 2
DCN decorin
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DHCR24 24-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPP4 dipeptidyl-peptidase 4
DPYSL3 dihydropyrimidinase-like 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
EPAS1 endothelial PAS domain protein 1
EPCAM epithelial cell adhesion molecule
ESRP1 epithelial splicing regulatory protein 1
FAR2 fatty acyl CoA reductase 2
FILIP1L filamin A interacting protein 1-like
FMO3 flavin containing monooxygenase 3
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
G0S2 G0/G1 switch 2
GAS6 growth arrest-specific 6
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HIST1H4C histone cluster 1, H4c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
ICAM2 intercellular adhesion molecule 2
IER3 immediate early response 3
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IL1R1 interleukin 1 receptor, type I
INHBA inhibin, beta A
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIAA0226L KIAA0226-like
KIAA1462 KIAA1462
KRT19 keratin 19, type I
LAPTM5 lysosomal protein transmembrane 5
LRRC15 leucine rich repeat containing 15
MAOB monoamine oxidase B
MMP9 matrix metallopeptidase 9
MN1 meningioma (disrupted in balanced translocation) 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1M metallothionein 1M
NDRG1 N-myc downstream regulated 1
NMU neuromedin U
ORM1 orosomucoid 1
PCP4 Purkinje cell protein 4
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PLS3 plastin 3
PRELP proline/arginine-rich end leucine-rich repeat protein
PTTG1IP pituitary tumor-transforming 1 interacting protein
PXDN peroxidasin
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCAN2 regulator of calcineurin 2
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCG2 secretogranin II
SCN3A sodium channel, voltage gated, type III alpha subunit
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SFTPB surfactant protein B
SPINK1 serine peptidase inhibitor, Kazal type 1
SULF1 sulfatase 1
TDO2 tryptophan 2,3-dioxygenase
TEK TEK tyrosine kinase, endothelial
THBS1 thrombospondin 1
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMSB15A thymosin beta 15a
VCAM1 vascular cell adhesion molecule 1
VTCN1 V-set domain containing T cell activation inhibitor 1
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ARID4B AT rich interactive domain 4B (RBP1-like)
ASXL2 additional sex combs like transcriptional regulator 2
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BLCAP bladder cancer associated protein
BRPF1 bromodomain and PHD finger containing, 1
C1ORF106 chromosome 1 open reading frame 106
CA12 carbonic anhydrase XII
CBR3 carbonyl reductase 3
CCDC86 coiled-coil domain containing 86
CCL5 chemokine (C-C motif) ligand 5
CCNF cyclin F
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHD7 chromodomain helicase DNA binding protein 7
CHERP calcium homeostasis endoplasmic reticulum protein
COIL coilin
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLG5 discs, large homolog 5 (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EGFR epidermal growth factor receptor
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EXOSC4 exosome component 4
FAM102A family with sequence similarity 102, member A
FASTKD5 FAST kinase domains 5
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GOLGA8A golgin A8 family, member A
GPATCH8 G patch domain containing 8
GRWD1 glutamate-rich WD repeat containing 1
GTPBP4 GTP binding protein 4
HEXIM1 hexamethylene bis-acetamide inducible 1
IER5 immediate early response 5
JADE2 jade family PHD finger 2
KAT6A K(lysine) acetyltransferase 6A
KAZN kazrin, periplakin interacting protein
KRT7 keratin 7, type II
KYNU kynureninase
LARP4B La ribonucleoprotein domain family, member 4B
MAPK6 mitogen-activated protein kinase 6
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MARCKS myristoylated alanine-rich protein kinase C substrate
MSL1 male-specific lethal 1 homolog (Drosophila)
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYLIP myosin regulatory light chain interacting protein
NCK1 NCK adaptor protein 1
NET1 neuroepithelial cell transforming 1
NOTCH2NL notch 2 N-terminal like
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PDGFA platelet-derived growth factor alpha polypeptide
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK2 polo-like kinase 2
PPIF peptidylprolyl isomerase F
PTCH1 patched 1
RAD9A RAD9 homolog A (S. pombe)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM38 RNA binding motif protein 38
RIN2 Ras and Rab interactor 2
RPP38 ribonuclease P/MRP 38kDa subunit
RPS11 ribosomal protein S11
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RUNX3 runt-related transcription factor 3
S100P S100 calcium binding protein P
SACS sacsin molecular chaperone
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SETD5 SET domain containing 5
SFRP1 secreted frizzled-related protein 1
SIK1 salt-inducible kinase 1
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLPI secretory leukocyte peptidase inhibitor
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SPATA2 spermatogenesis associated 2
SPRY2 sprouty homolog 2 (Drosophila)
SRGN serglycin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC2 transforming, acidic coiled-coil containing protein 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TEX10 testis expressed 10
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM11 transmembrane protein 11
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
UPK1B uroplakin 1B
VCAN versican
VCPKMT valosin containing protein lysine (K) methyltransferase
VGLL4 vestigial-like family member 4
WDR6 WD repeat domain 6
WDR82 WD repeat domain 82
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
ZBTB1 zinc finger and BTB domain containing 1
ZBTB38 zinc finger and BTB domain containing 38
ZMYND8 zinc finger, MYND-type containing 8