BRD-K77681376_2-morpholino-N-((4-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

322 genes differentially expressed following the BRD-K77681376_2-morpholino-N-((4-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ADGRA2 adhesion G protein-coupled receptor A2
ADIRF adipogenesis regulatory factor
ALCAM activated leukocyte cell adhesion molecule
ANPEP alanyl (membrane) aminopeptidase
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APLP2 amyloid beta (A4) precursor-like protein 2
AQP9 aquaporin 9
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG6 BCL2-associated athanogene 6
BHLHE40 basic helix-loop-helix family, member e40
BSG basigin (Ok blood group)
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
C3 complement component 3
C7 complement component 7
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCDC85B coiled-coil domain containing 85B
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CD177 CD177 molecule
CD52 CD52 molecule
CD69 CD69 molecule
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFB complement factor B
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLDN5 claudin 5
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTSL cathepsin L
CTSZ cathepsin Z
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DPYD dihydropyrimidine dehydrogenase
DUSP1 dual specificity phosphatase 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHD1 EF-hand domain family, member D1
EGR1 early growth response 1
EGR3 early growth response 3
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ESYT1 extended synaptotagmin-like protein 1
EXPH5 exophilin 5
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GANAB glucosidase, alpha; neutral AB
GAS6 growth arrest-specific 6
GATA2 GATA binding protein 2
GDE1 glycerophosphodiester phosphodiesterase 1
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPX3 glutathione peroxidase 3
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H1FX H1 histone family, member X
HBB hemoglobin, beta
HDLBP high density lipoprotein binding protein
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HOXA5 homeobox A5
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IFT57 intraflagellar transport 57
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGLL1 immunoglobulin lambda-like polypeptide 1
IL6 interleukin 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDR kinase insert domain receptor
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLHDC3 kelch domain containing 3
LAPTM4B lysosomal protein transmembrane 4 beta
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LTB lymphotoxin beta (TNF superfamily, member 3)
LTBP3 latent transforming growth factor beta binding protein 3
LYN LYN proto-oncogene, Src family tyrosine kinase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGED2 melanoma antigen family D2
MN1 meningioma (disrupted in balanced translocation) 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEFL neurofilament, light polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
ORM1 orosomucoid 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCSK6 proprotein convertase subtilisin/kexin type 6
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLD3 phospholipase D family, member 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PSENEN presenilin enhancer gamma secretase subunit
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SELENBP1 selenium binding protein 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SFTPB surfactant protein B
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLPI secretory leukocyte peptidase inhibitor
SMYD3 SET and MYND domain containing 3
SOX4 SRY (sex determining region Y)-box 4
TGFB1 transforming growth factor, beta 1
TMSB15A thymosin beta 15a
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNNC1 troponin C type 1 (slow)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIB1 tribbles pseudokinase 1
TSC22D1 TSC22 domain family, member 1
TUBA1A tubulin, alpha 1a
VTCN1 V-set domain containing T cell activation inhibitor 1
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ADNP activity-dependent neuroprotector homeobox
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
AP5M1 adaptor-related protein complex 5, mu 1 subunit
ARID4B AT rich interactive domain 4B (RBP1-like)
ASF1A anti-silencing function 1A histone chaperone
ATF1 activating transcription factor 1
AURKA aurora kinase A
BAG5 BCL2-associated athanogene 5
BASP1 brain abundant, membrane attached signal protein 1
BCAR3 breast cancer anti-estrogen resistance 3
CANT1 calcium activated nucleotidase 1
CASP8AP2 caspase 8 associated protein 2
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNF cyclin F
CD58 CD58 molecule
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CENPA centromere protein A
CEP350 centrosomal protein 350kDa
CEP76 centrosomal protein 76kDa
CHD1 chromodomain helicase DNA binding protein 1
CIAPIN1 cytokine induced apoptosis inhibitor 1
COG2 component of oligomeric golgi complex 2
CREM cAMP responsive element modulator
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRNKL1 crooked neck pre-mRNA splicing factor 1
CRY1 cryptochrome circadian clock 1
CSNK1D casein kinase 1, delta
DAAM1 dishevelled associated activator of morphogenesis 1
DBF4 DBF4 zinc finger
DHRS2 dehydrogenase/reductase (SDR family) member 2
DICER1 dicer 1, ribonuclease type III
DKFZP586I1420 uncharacterized protein DKFZp586I1420
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP14 dual specificity phosphatase 14
DUSP4 dual specificity phosphatase 4
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EED embryonic ectoderm development
EIF4E eukaryotic translation initiation factor 4E
EXOSC4 exosome component 4
FABP7 fatty acid binding protein 7, brain
FAM208B family with sequence similarity 208, member B
FAM57A family with sequence similarity 57, member A
FASTKD5 FAST kinase domains 5
FBXL12 F-box and leucine-rich repeat protein 12
FBXO28 F-box protein 28
FOXJ3 forkhead box J3
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GGNBP2 gametogenetin binding protein 2
GINS1 GINS complex subunit 1 (Psf1 homolog)
GRWD1 glutamate-rich WD repeat containing 1
GTF2B general transcription factor IIB
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOMER1 homer scaffolding protein 1
HOPX HOP homeobox
IPO7 importin 7
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
IST1 increased sodium tolerance 1 homolog (yeast)
JADE1 jade family PHD finger 1
JMJD6 jumonji domain containing 6
KANK1 KN motif and ankyrin repeat domains 1
KEAP1 kelch-like ECH-associated protein 1
KIAA0485 uncharacterized LOC57235
KLHL9 kelch-like family member 9
KRBOX4 KRAB box domain containing 4
KRT7 keratin 7, type II
KYNU kynureninase
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
LHX2 LIM homeobox 2
LPAR1 lysophosphatidic acid receptor 1
MAB21L1 mab-21-like 1 (C. elegans)
MAK16 MAK16 homolog (S. cerevisiae)
MAPK6 mitogen-activated protein kinase 6
MBNL2 muscleblind-like splicing regulator 2
MED13 mediator complex subunit 13
MEPCE methylphosphate capping enzyme
MFAP1 microfibrillar-associated protein 1
MID1 midline 1
MRPL46 mitochondrial ribosomal protein L46
MTCL1 microtubule crosslinking factor 1
MTF2 metal response element binding transcription factor 2
MTPAP mitochondrial poly(A) polymerase
N4BP2L2 NEDD4 binding protein 2-like 2
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NOL11 nucleolar protein 11
NOP16 NOP16 nucleolar protein
NOTCH2NL notch 2 N-terminal like
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
PDGFA platelet-derived growth factor alpha polypeptide
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
PNN pinin, desmosome associated protein
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPARG peroxisome proliferator-activated receptor gamma
PRPF4 pre-mRNA processing factor 4
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PTRH2 peptidyl-tRNA hydrolase 2
PXDC1 PX domain containing 1
RAE1 ribonucleic acid export 1
RBM12 RNA binding motif protein 12
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RIN2 Ras and Rab interactor 2
RNF219 ring finger protein 219
RNF4 ring finger protein 4
RNMT RNA (guanine-7-) methyltransferase
RPP38 ribonuclease P/MRP 38kDa subunit
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RYBP RING1 and YY1 binding protein
SACS sacsin molecular chaperone
SCAF8 SR-related CTD-associated factor 8
SCGB2A2 secretoglobin, family 2A, member 2
SLBP stem-loop binding protein
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMG8 SMG8 nonsense mediated mRNA decay factor
SNRPE small nuclear ribonucleoprotein polypeptide E
SNRPG small nuclear ribonucleoprotein polypeptide G
SNX11 sorting nexin 11
SPATA5L1 spermatogenesis associated 5-like 1
SPEN spen family transcriptional repressor
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNJ2 synaptojanin 2
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TBP TATA box binding protein
TBPL1 TBP-like 1
TEFM transcription elongation factor, mitochondrial
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM11 transmembrane protein 11
TNPO1 transportin 1
TP53BP2 tumor protein p53 binding protein 2
TRIM9 tripartite motif containing 9
TSC22D2 TSC22 domain family, member 2
TYRP1 tyrosinase-related protein 1
UMPS uridine monophosphate synthetase
UQCRH ubiquinol-cytochrome c reductase hinge protein
USP1 ubiquitin specific peptidase 1
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
WAPAL wings apart-like homolog (Drosophila)
WEE1 WEE1 G2 checkpoint kinase
YTHDC1 YTH domain containing 1
ZCCHC2 zinc finger, CCHC domain containing 2
ZCCHC8 zinc finger, CCHC domain containing 8
ZNF131 zinc finger protein 131
ZNF146 zinc finger protein 146
ZNF189 zinc finger protein 189
ZNF200 zinc finger protein 200
ZNF22 zinc finger protein 22
ZNF330 zinc finger protein 330
ZNHIT3 zinc finger, HIT-type containing 3