BRD-K77625799_vandetanib_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

122 genes differentially expressed following the BRD-K77625799_vandetanib_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
AGR2 anterior gradient 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ASRGL1 asparaginase like 1
BAD BCL2-associated agonist of cell death
BASP1 brain abundant, membrane attached signal protein 1
BLVRB biliverdin reductase B
C14ORF132 chromosome 14 open reading frame 132
C2CD5 C2 calcium-dependent domain containing 5
CAPN1 calpain 1, (mu/I) large subunit
CCNG2 cyclin G2
CLDN10 claudin 10
CLU clusterin
CRIP1 cysteine-rich protein 1 (intestinal)
CST3 cystatin C
CTSD cathepsin D
CYBA cytochrome b-245, alpha polypeptide
DHCR24 24-dehydrocholesterol reductase
DPP4 dipeptidyl-peptidase 4
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F13A1 coagulation factor XIII, A1 polypeptide
FBLN1 fibulin 1
FHL1 four and a half LIM domains 1
FLNA filamin A, alpha
FXYD3 FXYD domain containing ion transport regulator 3
GPX4 glutathione peroxidase 4
H1F0 H1 histone family, member 0
H2BFS H2B histone family, member S (pseudogene)
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST3H2A histone cluster 3, H2a
HMG20B high mobility group 20B
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPB8 heat shock 22kDa protein 8
LAMP2 lysosomal-associated membrane protein 2
MAL mal, T-cell differentiation protein
MEIS1 Meis homeobox 1
MUC1 mucin 1, cell surface associated
MYH10 myosin, heavy chain 10, non-muscle
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PBX1 pre-B-cell leukemia homeobox 1
PDZK1 PDZ domain containing 1
PDZK1IP1 PDZK1 interacting protein 1
PPL periplakin
PRDX2 peroxiredoxin 2
PRKCB protein kinase C, beta
PYCARD PYD and CARD domain containing
QPRT quinolinate phosphoribosyltransferase
REC8 REC8 meiotic recombination protein
S100P S100 calcium binding protein P
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC44A4 solute carrier family 44, member 4
TKT transketolase
TM7SF2 transmembrane 7 superfamily member 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAT1 vesicle amine transport 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AGO2 argonaute RISC catalytic component 2
ARL4C ADP-ribosylation factor-like 4C
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
CCDC86 coiled-coil domain containing 86
CCL2 chemokine (C-C motif) ligand 2
CCNE2 cyclin E2
CDC42 cell division cycle 42
CDC45 cell division cycle 45
CHIC2 cysteine-rich hydrophobic domain 2
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EPHA3 EPH receptor A3
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM69A family with sequence similarity 69, member A
FOSL1 FOS-like antigen 1
GPM6B glycoprotein M6B
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
IER3 immediate early response 3
IL13RA2 interleukin 13 receptor, alpha 2
INHBA inhibin, beta A
ITGA6 integrin, alpha 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MT1X metallothionein 1X
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NT5E 5'-nucleotidase, ecto (CD73)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAT plasminogen activator, tissue
PNP purine nucleoside phosphorylase
RGS4 regulator of G-protein signaling 4
SCRG1 stimulator of chondrogenesis 1
SFRP1 secreted frizzled-related protein 1
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SPRY2 sprouty homolog 2 (Drosophila)
TM4SF1 transmembrane 4 L six family member 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
WDR43 WD repeat domain 43
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing