BRD-K77547920_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

158 genes differentially expressed following the BRD-K77547920_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATM ATM serine/threonine kinase
BCL6 B-cell CLL/lymphoma 6
BTG1 B-cell translocation gene 1, anti-proliferative
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHIC2 cysteine-rich hydrophobic domain 2
CLDN3 claudin 3
CLEC7A C-type lectin domain family 7, member A
CSRP2 cysteine and glycine-rich protein 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DST dystonin
DUSP1 dual specificity phosphatase 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FZD7 frizzled class receptor 7
G6PD glucose-6-phosphate dehydrogenase
GADD45B growth arrest and DNA-damage-inducible, beta
GCLM glutamate-cysteine ligase, modifier subunit
GEM GTP binding protein overexpressed in skeletal muscle
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM1 intercellular adhesion molecule 1
IFRD1 interferon-related developmental regulator 1
IRS2 insulin receptor substrate 2
JUN jun proto-oncogene
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
KRT18 keratin 18, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LPAR1 lysophosphatidic acid receptor 1
LY96 lymphocyte antigen 96
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MBNL2 muscleblind-like splicing regulator 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MT1M metallothionein 1M
NMRK1 nicotinamide riboside kinase 1
NPC1 Niemann-Pick disease, type C1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
P3H2 prolyl 3-hydroxylase 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PALLD palladin, cytoskeletal associated protein
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTHLH parathyroid hormone-like hormone
PTPRK protein tyrosine phosphatase, receptor type, K
PTX3 pentraxin 3, long
RCAN1 regulator of calcineurin 1
RGCC regulator of cell cycle
RIPK2 receptor-interacting serine-threonine kinase 2
RND3 Rho family GTPase 3
RNMT RNA (guanine-7-) methyltransferase
S100A9 S100 calcium binding protein A9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERTAD2 SERTA domain containing 2
SFN stratifin
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRGN serglycin
SYT1 synaptotagmin I
TACSTD2 tumor-associated calcium signal transducer 2
TMEM45A transmembrane protein 45A
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB1 tribbles pseudokinase 1
TXNRD1 thioredoxin reductase 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACSF2 acyl-CoA synthetase family member 2
ADCY1 adenylate cyclase 1 (brain)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AURKA aurora kinase A
BST2 bone marrow stromal cell antigen 2
C14ORF132 chromosome 14 open reading frame 132
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNF cyclin F
CDK1 cyclin-dependent kinase 1
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DHCR24 24-dehydrocholesterol reductase
DMD dystrophin
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM162A family with sequence similarity 162, member A
FBXO9 F-box protein 9
FKBP1B FK506 binding protein 1B, 12.6 kDa
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPER1 G protein-coupled estrogen receptor 1
GSTM3 glutathione S-transferase mu 3 (brain)
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HES1 hes family bHLH transcription factor 1
HIST1H4C histone cluster 1, H4c
HOXB2 homeobox B2
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IFRD2 interferon-related developmental regulator 2
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL17RB interleukin 17 receptor B
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAMC1 laminin, gamma 1 (formerly LAMB2)
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MARCKSL1 MARCKS-like 1
MGLL monoglyceride lipase
MLEC malectin
PCGF2 polycomb group ring finger 2
PDHB pyruvate dehydrogenase (lipoamide) beta
PGAM1 phosphoglycerate mutase 1 (brain)
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLK1 polo-like kinase 1
PON2 paraoxonase 2
PTGER3 prostaglandin E receptor 3 (subtype EP3)
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SEPP1 selenoprotein P, plasma, 1
SRSF1 serine/arginine-rich splicing factor 1
SRSF6 serine/arginine-rich splicing factor 6
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TF transferrin
THY1 Thy-1 cell surface antigen
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2C ubiquitin-conjugating enzyme E2C