BRD-K77547509_3-cyclohexyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

45 genes differentially expressed following the BRD-K77547509_3-cyclohexyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
CD36 CD36 molecule (thrombospondin receptor)
DLK1 delta-like 1 homolog (Drosophila)
DUSP14 dual specificity phosphatase 14
EZR ezrin
FGF13 fibroblast growth factor 13
GLS glutaminase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXB2 homeobox B2
IDI1 isopentenyl-diphosphate delta isomerase 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
PHACTR2 phosphatase and actin regulator 2
PLK2 polo-like kinase 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRAME preferentially expressed antigen in melanoma
QPCT glutaminyl-peptide cyclotransferase
S100A10 S100 calcium binding protein A10
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLPI secretory leukocyte peptidase inhibitor
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
TPD52L1 tumor protein D52-like 1
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
BRCA1 breast cancer 1, early onset
C8ORF4 chromosome 8 open reading frame 4
CLGN calmegin
IRS2 insulin receptor substrate 2
KRT19 keratin 19, type I
MT1F metallothionein 1F
MT1M metallothionein 1M
MT1X metallothionein 1X
MYBPC1 myosin binding protein C, slow type
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PARM1 prostate androgen-regulated mucin-like protein 1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
TMEM5 transmembrane protein 5
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UBE3C ubiquitin protein ligase E3C