BRD-K77547509_3-cyclohexyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-K77547509_3-cyclohexyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMDEC1 ADAM-like, decysin 1
ADI1 acireductone dioxygenase 1
ANPEP alanyl (membrane) aminopeptidase
AREG amphiregulin
ARMCX6 armadillo repeat containing, X-linked 6
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
CA12 carbonic anhydrase XII
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CD24 CD24 molecule
CDC25B cell division cycle 25B
CDC42 cell division cycle 42
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CGRRF1 cell growth regulator with ring finger domain 1
CLEC2B C-type lectin domain family 2, member B
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
COMP cartilage oligomeric matrix protein
CPB1 carboxypeptidase B1 (tissue)
DLD dihydrolipoamide dehydrogenase
EFHD1 EF-hand domain family, member D1
EMP1 epithelial membrane protein 1
EREG epiregulin
FKBP1B FK506 binding protein 1B, 12.6 kDa
GLRX glutaredoxin (thioltransferase)
KRT14 keratin 14, type I
LIMS1 LIM and senescent cell antigen-like domains 1
LMO2 LIM domain only 2 (rhombotin-like 1)
MAGED1 melanoma antigen family D1
MARCKS myristoylated alanine-rich protein kinase C substrate
MFAP5 microfibrillar associated protein 5
PLK1 polo-like kinase 1
RACGAP1 Rac GTPase activating protein 1
RCAN1 regulator of calcineurin 1
RYBP RING1 and YY1 binding protein
S100A10 S100 calcium binding protein A10
SDCBP syndecan binding protein (syntenin)
SGK1 serum/glucocorticoid regulated kinase 1
STMN1 stathmin 1
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOB1 transducer of ERBB2, 1
TPM1 tropomyosin 1 (alpha)
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CCDC85B coiled-coil domain containing 85B
CD320 CD320 molecule
CKAP4 cytoskeleton-associated protein 4
CST1 cystatin SN
CTSE cathepsin E
DES desmin
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
EIF5A eukaryotic translation initiation factor 5A
FHOD3 formin homology 2 domain containing 3
FJX1 four jointed box 1 (Drosophila)
GAL galanin/GMAP prepropeptide
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ISG20 interferon stimulated exonuclease gene 20kDa
L1CAM L1 cell adhesion molecule
LAMA3 laminin, alpha 3
MAOA monoamine oxidase A
MAP2K5 mitogen-activated protein kinase kinase 5
MX1 MX dynamin-like GTPase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEFH neurofilament, heavy polypeptide
NELL2 NEL-like 2 (chicken)
NHP2 NHP2 ribonucleoprotein
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NOP16 NOP16 nucleolar protein
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PRKDC protein kinase, DNA-activated, catalytic polypeptide
SORBS1 sorbin and SH3 domain containing 1
ST7 suppression of tumorigenicity 7
TACC2 transforming, acidic coiled-coil containing protein 2
TESC tescalcin
TGM2 transglutaminase 2
TMEM5 transmembrane protein 5