BRD-K77547509_3-cyclohexyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

52 genes differentially expressed following the BRD-K77547509_3-cyclohexyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CD24 CD24 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CSTA cystatin A (stefin A)
CTNND1 catenin (cadherin-associated protein), delta 1
CXCL10 chemokine (C-X-C motif) ligand 10
FAM198B family with sequence similarity 198, member B
GJA1 gap junction protein, alpha 1, 43kDa
IER5 immediate early response 5
IGL immunoglobulin lambda locus
JCHAIN joining chain of multimeric IgA and IgM
KLK5 kallikrein-related peptidase 5
KRT5 keratin 5, type II
LCN2 lipocalin 2
LPAR6 lysophosphatidic acid receptor 6
MEIS2 Meis homeobox 2
NXN nucleoredoxin
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SPARCL1 SPARC-like 1 (hevin)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TCEA2 transcription elongation factor A (SII), 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
ADIRF adipogenesis regulatory factor
AXL AXL receptor tyrosine kinase
CA12 carbonic anhydrase XII
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DKK1 dickkopf WNT signaling pathway inhibitor 1
DST dystonin
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
HOXC6 homeobox C6
IGFBP4 insulin-like growth factor binding protein 4
JADE2 jade family PHD finger 2
LONP2 lon peptidase 2, peroxisomal
PFKP phosphofructokinase, platelet
PPARG peroxisome proliferator-activated receptor gamma
PRKCA protein kinase C, alpha
RNMT RNA (guanine-7-) methyltransferase
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
TFF1 trefoil factor 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIMP4 TIMP metallopeptidase inhibitor 4
TNC tenascin C