BRD-K77547509_3-cyclohexyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

50 genes differentially expressed following the BRD-K77547509_3-cyclohexyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AKAP12 A kinase (PRKA) anchor protein 12
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLCA4 chloride channel accessory 4
EMP1 epithelial membrane protein 1
EPAS1 endothelial PAS domain protein 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPNMB glycoprotein (transmembrane) nmb
GSN gelsolin
HBB hemoglobin, beta
HIC2 hypermethylated in cancer 2
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HSPA1A heat shock 70kDa protein 1A
IGFBP3 insulin-like growth factor binding protein 3
IGKC immunoglobulin kappa constant
IGKV4-1 immunoglobulin kappa variable 4-1
LAPTM5 lysosomal protein transmembrane 5
LCN2 lipocalin 2
MMP9 matrix metallopeptidase 9
NPTX2 neuronal pentraxin II
OPN3 opsin 3
S100A4 S100 calcium binding protein A4
SGK1 serum/glucocorticoid regulated kinase 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STEAP1 six transmembrane epithelial antigen of the prostate 1

decreased expression

Symbol Name
CD44 CD44 molecule (Indian blood group)
CDC25B cell division cycle 25B
ETFB electron-transfer-flavoprotein, beta polypeptide
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
KRT7 keratin 7, type II
MAPK13 mitogen-activated protein kinase 13
NFIB nuclear factor I/B
NME1 NME/NM23 nucleoside diphosphate kinase 1
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PRSS2 protease, serine, 2 (trypsin 2)
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SUB1 SUB1 homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TESC tescalcin
TMEM5 transmembrane protein 5
TOM1L1 target of myb1 (chicken)-like 1