BRD-K77547509_3-cyclohexyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

206 genes differentially expressed following the BRD-K77547509_3-cyclohexyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALB albumin
ALDOB aldolase B, fructose-bisphosphate
ANPEP alanyl (membrane) aminopeptidase
BEX1 brain expressed, X-linked 1
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CALR calreticulin
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
CLEC2B C-type lectin domain family 2, member B
COL4A5 collagen, type IV, alpha 5
CPA3 carboxypeptidase A3 (mast cell)
ECM1 extracellular matrix protein 1
ENG endoglin
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
FAM129A family with sequence similarity 129, member A
FCGBP Fc fragment of IgG binding protein
FN1 fibronectin 1
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
HHEX hematopoietically expressed homeobox
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPA2 heat shock 70kDa protein 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KLK5 kallikrein-related peptidase 5
KRT23 keratin 23, type I
LAPTM5 lysosomal protein transmembrane 5
MAN2A1 mannosidase, alpha, class 2A, member 1
MAOA monoamine oxidase A
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
NELL2 NEL-like 2 (chicken)
NRGN neurogranin (protein kinase C substrate, RC3)
ORM1 orosomucoid 1
PBX3 pre-B-cell leukemia homeobox 3
PDIA3 protein disulfide isomerase family A, member 3
PLVAP plasmalemma vesicle associated protein
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RGS1 regulator of G-protein signaling 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SPON2 spondin 2, extracellular matrix protein
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SST somatostatin
STC1 stanniocalcin 1
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRD T cell receptor delta locus
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ABI1 abl-interactor 1
ACBD3 acyl-CoA binding domain containing 3
ADI1 acireductone dioxygenase 1
AGR2 anterior gradient 2
ANXA3 annexin A3
APOD apolipoprotein D
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARMT1 acidic residue methyltransferase 1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF1 activating transcription factor 1
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
BASP1 brain abundant, membrane attached signal protein 1
BST2 bone marrow stromal cell antigen 2
BTBD3 BTB (POZ) domain containing 3
C6ORF62 chromosome 6 open reading frame 62
C7 complement component 7
C8ORF33 chromosome 8 open reading frame 33
C8ORF4 chromosome 8 open reading frame 4
CCL19 chemokine (C-C motif) ligand 19
CD24 CD24 molecule
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK4 cyclin-dependent kinase 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHMP4A charged multivesicular body protein 4A
CHPT1 choline phosphotransferase 1
CLU clusterin
COCH cochlin
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CP ceruloplasmin (ferroxidase)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRYAB crystallin, alpha B
CTTN cortactin
CXCL13 chemokine (C-X-C motif) ligand 13
CYC1 cytochrome c-1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DLD dihydrolipoamide dehydrogenase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DYNLT3 dynein, light chain, Tctex-type 3
DZIP1 DAZ interacting zinc finger protein 1
EBNA1BP2 EBNA1 binding protein 2
EED embryonic ectoderm development
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR3 early growth response 3
EIF4B eukaryotic translation initiation factor 4B
ELOVL5 ELOVL fatty acid elongase 5
ERBB3 erb-b2 receptor tyrosine kinase 3
ETNK1 ethanolamine kinase 1
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FXYD2 FXYD domain containing ion transport regulator 2
G0S2 G0/G1 switch 2
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GCH1 GTP cyclohydrolase 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GGT1 gamma-glutamyltransferase 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX3 glutathione peroxidase 3
GTPBP8 GTP-binding protein 8 (putative)
HDGFRP3 hepatoma-derived growth factor, related protein 3
HNMT histamine N-methyltransferase
HPRT1 hypoxanthine phosphoribosyltransferase 1
IFRD2 interferon-related developmental regulator 2
IGF1 insulin-like growth factor 1 (somatomedin C)
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KIF2C kinesin family member 2C
KYNU kynureninase
LACTB2 lactamase, beta 2
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LXN latexin
LYPLA1 lysophospholipase I
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MARCKS myristoylated alanine-rich protein kinase C substrate
MATN2 matrilin 2
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MLF1 myeloid leukemia factor 1
MMP10 matrix metallopeptidase 10
MPZL1 myelin protein zero-like 1
MRPL19 mitochondrial ribosomal protein L19
MTDH metadherin
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYO5C myosin VC
NBN nibrin
NEBL nebulette
NEFH neurofilament, heavy polypeptide
NFIB nuclear factor I/B
NPY1R neuropeptide Y receptor Y1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRIP1 nuclear receptor interacting protein 1
NUP98 nucleoporin 98kDa
OXR1 oxidation resistance 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PCYOX1 prenylcysteine oxidase 1
PEG10 paternally expressed 10
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
PLCB4 phospholipase C, beta 4
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
PRPF4 pre-mRNA processing factor 4
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGES prostaglandin E synthase
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBKS ribokinase
RBM3 RNA binding motif (RNP1, RRM) protein 3
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
S100A13 S100 calcium binding protein A13
SAMD4A sterile alpha motif domain containing 4A
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SGCE sarcoglycan, epsilon
SIK1 salt-inducible kinase 1
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC25A46 solute carrier family 25, member 46
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SPATA20 spermatogenesis associated 20
TBC1D16 TBC1 domain family, member 16
TCEAL4 transcription elongation factor A (SII)-like 4
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP4 TIMP metallopeptidase inhibitor 4
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TMEM106B transmembrane protein 106B
TMEM135 transmembrane protein 135
TOP2A topoisomerase (DNA) II alpha 170kDa
TSNAX translin-associated factor X
TSPAN13 tetraspanin 13
TSPAN31 tetraspanin 31
TSPYL5 TSPY-like 5
TUBB2B tubulin, beta 2B class IIb
TXNDC9 thioredoxin domain containing 9
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WRB tryptophan rich basic protein
YME1L1 YME1-like 1 ATPase
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZFAND1 zinc finger, AN1-type domain 1