BRD-K77547509_3-cyclohexyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

181 genes differentially expressed following the BRD-K77547509_3-cyclohexyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ARG1 arginase 1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CA4 carbonic anhydrase IV
CCND2 cyclin D2
CD36 CD36 molecule (thrombospondin receptor)
CD52 CD52 molecule
CD59 CD59 molecule, complement regulatory protein
CDC42 cell division cycle 42
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CLDN3 claudin 3
CLDN5 claudin 5
CPE carboxypeptidase E
CXCL14 chemokine (C-X-C motif) ligand 14
DLC1 DLC1 Rho GTPase activating protein
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
ESRP1 epithelial splicing regulatory protein 1
FHL1 four and a half LIM domains 1
GATA2 GATA binding protein 2
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GULP1 GULP, engulfment adaptor PTB domain containing 1
GYPC glycophorin C (Gerbich blood group)
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HTRA1 HtrA serine peptidase 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IGF1R insulin-like growth factor 1 receptor
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LCN2 lipocalin 2
MAP7 microtubule-associated protein 7
MIR22HG MIR22 host gene
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
NPTX2 neuronal pentraxin II
NRIP1 nuclear receptor interacting protein 1
OSBPL1A oxysterol binding protein-like 1A
PCIF1 PDX1 C-terminal inhibiting factor 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PELI1 pellino E3 ubiquitin protein ligase 1
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRR7 proline rich 7 (synaptic)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RGCC regulator of cell cycle
RNF11 ring finger protein 11
S100A10 S100 calcium binding protein A10
S100A8 S100 calcium binding protein A8
SFN stratifin
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SGK1 serum/glucocorticoid regulated kinase 1
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SPARCL1 SPARC-like 1 (hevin)
SPON1 spondin 1, extracellular matrix protein
STK17B serine/threonine kinase 17b
STX3 syntaxin 3
TIMP3 TIMP metallopeptidase inhibitor 3
TRA2B transformer 2 beta homolog (Drosophila)
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
UGCG UDP-glucose ceramide glucosyltransferase
VAMP3 vesicle-associated membrane protein 3
XIST X inactive specific transcript (non-protein coding)
ZBTB16 zinc finger and BTB domain containing 16

decreased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
AKAP11 A kinase (PRKA) anchor protein 11
ANKRD17 ankyrin repeat domain 17
ANKRD36B ankyrin repeat domain 36B
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATR ATR serine/threonine kinase
ATXN1 ataxin 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BRCA1 breast cancer 1, early onset
C1S complement component 1, s subcomponent
C2CD2 C2 calcium-dependent domain containing 2
CCNF cyclin F
CDK12 cyclin-dependent kinase 12
CDK19 cyclin-dependent kinase 19
CHD9 chromodomain helicase DNA binding protein 9
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DHRS2 dehydrogenase/reductase (SDR family) member 2
DIXDC1 DIX domain containing 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPP8 dipeptidyl-peptidase 8
DST dystonin
EDRF1 erythroid differentiation regulatory factor 1
FAM178A family with sequence similarity 178, member A
FAM208A family with sequence similarity 208, member A
FAM57A family with sequence similarity 57, member A
FBXW2 F-box and WD repeat domain containing 2
FNBP1 formin binding protein 1
FNDC3B fibronectin type III domain containing 3B
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLS glutaminase
GOLGA8A golgin A8 family, member A
GSAP gamma-secretase activating protein
GSTA4 glutathione S-transferase alpha 4
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa
HOXC10 homeobox C10
INTS6 integrator complex subunit 6
JADE1 jade family PHD finger 1
KIF14 kinesin family member 14
KRT7 keratin 7, type II
KYNU kynureninase
LAMB3 laminin, beta 3
LIMCH1 LIM and calponin homology domains 1
LINC00342 long intergenic non-protein coding RNA 342
LOC100272216 uncharacterized LOC100272216
MACF1 microtubule-actin crosslinking factor 1
MBNL2 muscleblind-like splicing regulator 2
MED13 mediator complex subunit 13
MET MET proto-oncogene, receptor tyrosine kinase
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MTDH metadherin
N4BP2L2 NEDD4 binding protein 2-like 2
NMT1 N-myristoyltransferase 1
NT5E 5'-nucleotidase, ecto (CD73)
NUP62 nucleoporin 62kDa
OSMR oncostatin M receptor
PDLIM5 PDZ and LIM domain 5
PDS5A PDS5 cohesin associated factor A
PHIP pleckstrin homology domain interacting protein
PLAC8 placenta-specific 8
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLS1 plastin 1
PLS3 plastin 3
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
PNISR PNN-interacting serine/arginine-rich protein
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRPF4 pre-mRNA processing factor 4
PSPC1 paraspeckle component 1
PTPN2 protein tyrosine phosphatase, non-receptor type 2
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RABGAP1 RAB GTPase activating protein 1
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic)
RPL31 ribosomal protein L31
SENP6 SUMO1/sentrin specific peptidase 6
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SETX senataxin
SON SON DNA binding protein
SPG11 spastic paraplegia 11 (autosomal recessive)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STX1A syntaxin 1A (brain)
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae)
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
TBC1D31 TBC1 domain family, member 31
TGM2 transglutaminase 2
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM2 transmembrane protein 2
TMEM5 transmembrane protein 5
TNS3 tensin 3
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TTC28 tetratricopeptide repeat domain 28
UBE3C ubiquitin protein ligase E3C
VPS13B vacuolar protein sorting 13 homolog B (yeast)
ZC3H13 zinc finger CCCH-type containing 13
ZMIZ1 zinc finger, MIZ-type containing 1
ZMYM2 zinc finger, MYM-type 2
ZMYM4 zinc finger, MYM-type 4
ZNF146 zinc finger protein 146
ZNF451 zinc finger protein 451
ZNF638 zinc finger protein 638