BRD-K77547509_3-cyclohexyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

162 genes differentially expressed following the BRD-K77547509_3-cyclohexyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AKR1C3 aldo-keto reductase family 1, member C3
APLP2 amyloid beta (A4) precursor-like protein 2
ARG2 arginase 2
ATF3 activating transcription factor 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNG2 cyclin G2
CD48 CD48 molecule
CD52 CD52 molecule
CD93 CD93 molecule
CD99 CD99 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN2A cyclin-dependent kinase inhibitor 2A
CECR1 cat eye syndrome chromosome region, candidate 1
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CRIP1 cysteine-rich protein 1 (intestinal)
CTSH cathepsin H
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
DCN decorin
DIDO1 death inducer-obliterator 1
EGR2 early growth response 2
EMP1 epithelial membrane protein 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPCAM epithelial cell adhesion molecule
ESR1 estrogen receptor 1
ESRP1 epithelial splicing regulatory protein 1
FBLN1 fibulin 1
FBXO11 F-box protein 11
G0S2 G0/G1 switch 2
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GSTA1 glutathione S-transferase alpha 1
HDAC9 histone deacetylase 9
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ISOC1 isochorismatase domain containing 1
ISYNA1 inositol-3-phosphate synthase 1
ITM2A integral membrane protein 2A
KLF10 Kruppel-like factor 10
KLHL7 kelch-like family member 7
KRT19 keratin 19, type I
KRT5 keratin 5, type II
LAPTM5 lysosomal protein transmembrane 5
LCN2 lipocalin 2
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LPAR6 lysophosphatidic acid receptor 6
LUM lumican
MARCKSL1 MARCKS-like 1
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MOAP1 modulator of apoptosis 1
MXRA5 matrix-remodelling associated 5
NEFH neurofilament, heavy polypeptide
NOV nephroblastoma overexpressed
NPTX2 neuronal pentraxin II
OLFM1 olfactomedin 1
ORM1 orosomucoid 1
PAK1IP1 PAK1 interacting protein 1
PAPOLA poly(A) polymerase alpha
PCDH7 protocadherin 7
PCP4 Purkinje cell protein 4
PECAM1 platelet/endothelial cell adhesion molecule 1
PELI1 pellino E3 ubiquitin protein ligase 1
PFN2 profilin 2
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPP1R13B protein phosphatase 1, regulatory subunit 13B
QPCT glutaminyl-peptide cyclotransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGCC regulator of cell cycle
RSRP1 arginine/serine-rich protein 1
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SORT1 sortilin 1
SPARCL1 SPARC-like 1 (hevin)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SST somatostatin
STK17B serine/threonine kinase 17b
STS steroid sulfatase (microsomal), isozyme S
SYT1 synaptotagmin I
TACSTD2 tumor-associated calcium signal transducer 2
THBS2 thrombospondin 2
TMEM30B transmembrane protein 30B
TMEM47 transmembrane protein 47
TPD52L1 tumor protein D52-like 1
TPSAB1 tryptase alpha/beta 1
TSPAN13 tetraspanin 13
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ANKRD36B ankyrin repeat domain 36B
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
AQP3 aquaporin 3 (Gill blood group)
ASXL2 additional sex combs like transcriptional regulator 2
ATM ATM serine/threonine kinase
BRCA1 breast cancer 1, early onset
CA12 carbonic anhydrase XII
CAPRIN2 caprin family member 2
CD70 CD70 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CFD complement factor D (adipsin)
CHL1 cell adhesion molecule L1-like
CREB1 cAMP responsive element binding protein 1
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
CX3CR1 chemokine (C-X3-C motif) receptor 1
EPN2 epsin 2
EXOSC4 exosome component 4
FCGBP Fc fragment of IgG binding protein
FOLR1 folate receptor 1 (adult)
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLI2 GLI family zinc finger 2
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
HBB hemoglobin, beta
JADE2 jade family PHD finger 2
LYST lysosomal trafficking regulator
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
NCAM1 neural cell adhesion molecule 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NMT1 N-myristoyltransferase 1
NOTCH2NL notch 2 N-terminal like
OLIG2 oligodendrocyte lineage transcription factor 2
PCBP4 poly(rC) binding protein 4
PF4 platelet factor 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PPARG peroxisome proliferator-activated receptor gamma
PPP1R10 protein phosphatase 1, regulatory subunit 10
PRKCA protein kinase C, alpha
PURA purine-rich element binding protein A
SATB2 SATB homeobox 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SPRR3 small proline-rich protein 3
STC1 stanniocalcin 1
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM2 transmembrane protein 2
TRAK2 trafficking protein, kinesin binding 2
TRIP6 thyroid hormone receptor interactor 6
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN5 tetraspanin 5
UBE3C ubiquitin protein ligase E3C