BRD-K76969307_CG-930_HEPG2_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

125 genes differentially expressed following the BRD-K76969307_CG-930_HEPG2_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAA1 acetyl-CoA acyltransferase 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANPEP alanyl (membrane) aminopeptidase
CFB complement factor B
CXCL5 chemokine (C-X-C motif) ligand 5
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR7 7-dehydrocholesterol reductase
ELOVL2 ELOVL fatty acid elongase 2
F12 coagulation factor XII (Hageman factor)
FADS1 fatty acid desaturase 1
FGFR2 fibroblast growth factor receptor 2
GLCE glucuronic acid epimerase
GPM6A glycoprotein M6A
HMOX1 heme oxygenase 1
HSDL2 hydroxysteroid dehydrogenase like 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL6ST interleukin 6 signal transducer
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LAMP1 lysosomal-associated membrane protein 1
LBH limb bud and heart development
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LY75 lymphocyte antigen 75
MMP7 matrix metallopeptidase 7
MSLN mesothelin
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
PDE4B phosphodiesterase 4B, cAMP-specific
PDZK1 PDZ domain containing 1
PRKD3 protein kinase D3
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTX3 pentraxin 3, long
RAB29 RAB29, member RAS oncogene family
RAB4A RAB4A, member RAS oncogene family
RBM15B RNA binding motif protein 15B
RRAGD Ras-related GTP binding D
SASH1 SAM and SH3 domain containing 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SORD sorbitol dehydrogenase
TBX3 T-box 3
TSPAN3 tetraspanin 3

decreased expression

Symbol Name
AEBP1 AE binding protein 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA1 annexin A1
AQP3 aquaporin 3 (Gill blood group)
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BHLHE40 basic helix-loop-helix family, member e40
CA12 carbonic anhydrase XII
CD24 CD24 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD86 CD86 molecule
CDA cytidine deaminase
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CISH cytokine inducible SH2-containing protein
CLEC2B C-type lectin domain family 2, member B
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CST7 cystatin F (leukocystatin)
CXCL12 chemokine (C-X-C motif) ligand 12
DACT1 dishevelled-binding antagonist of beta-catenin 1
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EXOSC4 exosome component 4
F13A1 coagulation factor XIII, A1 polypeptide
F3 coagulation factor III (thromboplastin, tissue factor)
FBN1 fibrillin 1
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HSPH1 heat shock 105kDa/110kDa protein 1
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRT6B keratin 6B, type II
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPIN1 lipin 1
MAL mal, T-cell differentiation protein
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MKNK1 MAP kinase interacting serine/threonine kinase 1
MRPS2 mitochondrial ribosomal protein S2
NRP1 neuropilin 1
OLFML2B olfactomedin-like 2B
PAPD7 PAP associated domain containing 7
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
RFTN1 raftlin, lipid raft linker 1
S100A11 S100 calcium binding protein A11
S100A2 S100 calcium binding protein A2
SCG5 secretogranin V
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP4 secreted frizzled-related protein 4
SNAI2 snail family zinc finger 2
SOX4 SRY (sex determining region Y)-box 4
SPATS2L spermatogenesis associated, serine-rich 2-like
SST somatostatin
TFPI2 tissue factor pathway inhibitor 2
THBS2 thrombospondin 2
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TPM1 tropomyosin 1 (alpha)
TPM4 tropomyosin 4
TUBB6 tubulin, beta 6 class V
UPP1 uridine phosphorylase 1
VAMP8 vesicle-associated membrane protein 8
WT1 Wilms tumor 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFP36L1 ZFP36 ring finger protein-like 1