BRD-K76908866_CP-724714_SKBR3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

118 genes differentially expressed following the BRD-K76908866_CP-724714_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADD3 adducin 3 (gamma)
ANO1 anoctamin 1, calcium activated chloride channel
BHLHE40 basic helix-loop-helix family, member e40
CAPN1 calpain 1, (mu/I) large subunit
CD300A CD300a molecule
CLDN3 claudin 3
CLMN calmin (calponin-like, transmembrane)
CPT1A carnitine palmitoyltransferase 1A (liver)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DUSP14 dual specificity phosphatase 14
EFNA1 ephrin-A1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
EXPH5 exophilin 5
FOXN3 forkhead box N3
GAB2 GRB2-associated binding protein 2
GAS6 growth arrest-specific 6
GLUL glutamate-ammonia ligase
GRB7 growth factor receptor-bound protein 7
GSE1 Gse1 coiled-coil protein
GSTM3 glutathione S-transferase mu 3 (brain)
GSTT1 glutathione S-transferase theta 1
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HNMT histamine N-methyltransferase
KIAA1033 KIAA1033
KRT19 keratin 19, type I
LXN latexin
MLPH melanophilin
MUC1 mucin 1, cell surface associated
MVP major vault protein
NEBL nebulette
NPDC1 neural proliferation, differentiation and control, 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SCARB2 scavenger receptor class B, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SECISBP2L SECIS binding protein 2-like
SELENBP1 selenium binding protein 1
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SPDEF SAM pointed domain containing ETS transcription factor
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TSC22D1 TSC22 domain family, member 1
VTCN1 V-set domain containing T cell activation inhibitor 1
VWA5A von Willebrand factor A domain containing 5A
WRB tryptophan rich basic protein
XBP1 X-box binding protein 1
ZKSCAN1 zinc finger with KRAB and SCAN domains 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
AEBP1 AE binding protein 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CCND3 cyclin D3
CCNE2 cyclin E2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKS2 CDC28 protein kinase regulatory subunit 2
CSRP1 cysteine and glycine-rich protein 1
DCK deoxycytidine kinase
DLK1 delta-like 1 homolog (Drosophila)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FGFR2 fibroblast growth factor receptor 2
FN1 fibronectin 1
FOXM1 forkhead box M1
GAL galanin/GMAP prepropeptide
GCH1 GTP cyclohydrolase 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
HBB hemoglobin, beta
HIST1H4C histone cluster 1, H4c
IGL immunoglobulin lambda locus
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL13RA2 interleukin 13 receptor, alpha 2
KIF18B kinesin family member 18B
KPNA3 karyopherin alpha 3 (importin alpha 4)
LAGE3 L antigen family, member 3
LAPTM5 lysosomal protein transmembrane 5
LMNB1 lamin B1
LSM12 LSM12 homolog (S. cerevisiae)
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MKI67 marker of proliferation Ki-67
NPY1R neuropeptide Y receptor Y1
NUSAP1 nucleolar and spindle associated protein 1
PBK PDZ binding kinase
PLK1 polo-like kinase 1
POSTN periostin, osteoblast specific factor
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RAD23B RAD23 homolog B (S. cerevisiae)
RRM2 ribonucleotide reductase M2
SPP1 secreted phosphoprotein 1
STMN1 stathmin 1
SULF1 sulfatase 1
TLR4 toll-like receptor 4
TMEM97 transmembrane protein 97
TNC tenascin C
TPM1 tropomyosin 1 (alpha)
TUBG1 tubulin, gamma 1
UBE2C ubiquitin-conjugating enzyme E2C
VCAM1 vascular cell adhesion molecule 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein