BRD-K76694128_DCC-2036_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

170 genes differentially expressed following the BRD-K76694128_DCC-2036_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACBD3 acyl-CoA binding domain containing 3
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADD3 adducin 3 (gamma)
AIM1 absent in melanoma 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
BAG3 BCL2-associated athanogene 3
BBX bobby sox homolog (Drosophila)
CCL19 chemokine (C-C motif) ligand 19
CD36 CD36 molecule (thrombospondin receptor)
CD52 CD52 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CFLAR CASP8 and FADD-like apoptosis regulator
CST3 cystatin C
CTSL cathepsin L
CTSZ cathepsin Z
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FGFR1 fibroblast growth factor receptor 1
FHL2 four and a half LIM domains 2
FKBP1A FK506 binding protein 1A, 12kDa
FLRT2 fibronectin leucine rich transmembrane protein 2
GLG1 golgi glycoprotein 1
GLIPR1 GLI pathogenesis-related 1
GLRX glutaredoxin (thioltransferase)
GSN gelsolin
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOXB2 homeobox B2
HOXB7 homeobox B7
HSPA1A heat shock 70kDa protein 1A
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
INPP1 inositol polyphosphate-1-phosphatase
ITGB5 integrin, beta 5
KLK11 kallikrein-related peptidase 11
KRT14 keratin 14, type I
KRT17 keratin 17, type I
LEF1 lymphoid enhancer-binding factor 1
MAGEA1 melanoma antigen family A1
MMP12 matrix metallopeptidase 12
NKX3-1 NK3 homeobox 1
NRIP3 nuclear receptor interacting protein 3
OSBPL8 oxysterol binding protein-like 8
PAWR PRKC, apoptosis, WT1, regulator
PICALM phosphatidylinositol binding clathrin assembly protein
PKN2 protein kinase N2
PMEPA1 prostate transmembrane protein, androgen induced 1
PRNP prion protein
PRSS21 protease, serine, 21 (testisin)
PTGDS prostaglandin D2 synthase 21kDa (brain)
RALB v-ral simian leukemia viral oncogene homolog B
RGS5 regulator of G-protein signaling 5
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SEPP1 selenoprotein P, plasma, 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SKP1 S-phase kinase-associated protein 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SPARCL1 SPARC-like 1 (hevin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SRGN serglycin
STEAP1 six transmembrane epithelial antigen of the prostate 1
TARP TCR gamma alternate reading frame protein
TCF4 transcription factor 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TES testin LIM domain protein
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TM9SF3 transmembrane 9 superfamily member 3
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMX4 thioredoxin-related transmembrane protein 4
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ACTA1 actin, alpha 1, skeletal muscle
AFP alpha-fetoprotein
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHSG alpha-2-HS-glycoprotein
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AMDHD2 amidohydrolase domain containing 2
ANXA4 annexin A4
ARFIP2 ADP-ribosylation factor interacting protein 2
BEX1 brain expressed, X-linked 1
BPIFA1 BPI fold containing family A, member 1
CADM1 cell adhesion molecule 1
CD300A CD300a molecule
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDK4 cyclin-dependent kinase 4
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHMP4A charged multivesicular body protein 4A
CKM creatine kinase, muscle
COL1A2 collagen, type I, alpha 2
COMT catechol-O-methyltransferase
CRYAB crystallin, alpha B
CYB5R1 cytochrome b5 reductase 1
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DAPK1 death-associated protein kinase 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DHCR7 7-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP1 fatty acid binding protein 1, liver
FABP7 fatty acid binding protein 7, brain
FAM216A family with sequence similarity 216, member A
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGFR4 fibroblast growth factor receptor 4
FGG fibrinogen gamma chain
GAMT guanidinoacetate N-methyltransferase
GATA3 GATA binding protein 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCAT glycine C-acetyltransferase
GPM6A glycoprotein M6A
HMOX1 heme oxygenase 1
HRSP12 heat-responsive protein 12
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KANK1 KN motif and ankyrin repeat domains 1
KAZN kazrin, periplakin interacting protein
KLHL41 kelch-like family member 41
KRT7 keratin 7, type II
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARCKS myristoylated alanine-rich protein kinase C substrate
MB myoglobin
MRPL12 mitochondrial ribosomal protein L12
MSRB1 methionine sulfoxide reductase B1
MUC16 mucin 16, cell surface associated
MYL1 myosin, light chain 1, alkali; skeletal, fast
NEB nebulin
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NIPSNAP1 nipsnap homolog 1 (C. elegans)
OBSL1 obscurin-like 1
OXA1L oxidase (cytochrome c) assembly 1-like
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDE4B phosphodiesterase 4B, cAMP-specific
PDE4DIP phosphodiesterase 4D interacting protein
PIPOX pipecolic acid oxidase
PIR pirin (iron-binding nuclear protein)
PLK2 polo-like kinase 2
PPIC peptidylprolyl isomerase C (cyclophilin C)
PROM1 prominin 1
PTGIS prostaglandin I2 (prostacyclin) synthase
PYCARD PYD and CARD domain containing
PYCR1 pyrroline-5-carboxylate reductase 1
PYGL phosphorylase, glycogen, liver
RTN2 reticulon 2
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX11 SRY (sex determining region Y)-box 11
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STRA13 stimulated by retinoic acid 13
TNNT1 troponin T type 1 (skeletal, slow)
TRIM16 tripartite motif containing 16
TTN titin
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WBP5 WW domain binding protein 5
ZIC1 Zic family member 1