BRD-K76674262_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

304 genes differentially expressed following the BRD-K76674262_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADM adrenomedullin
AKAP8L A kinase (PRKA) anchor protein 8-like
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
ATF7IP activating transcription factor 7 interacting protein
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BCL3 B-cell CLL/lymphoma 3
BHLHE41 basic helix-loop-helix family, member e41
BIRC3 baculoviral IAP repeat containing 3
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CA2 carbonic anhydrase II
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL19 chemokine (C-C motif) ligand 19
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CCNL1 cyclin L1
CDK17 cyclin-dependent kinase 17
CDKN2AIP CDKN2A interacting protein
CGRRF1 cell growth regulator with ring finger domain 1
CHIC2 cysteine-rich hydrophobic domain 2
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLK4 CDC-like kinase 4
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CYLD cylindromatosis (turban tumor syndrome)
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DMXL2 Dmx-like 2
DNMBP dynamin binding protein
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP6 dual specificity phosphatase 6
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ELANE elastase, neutrophil expressed
FAM179B family with sequence similarity 179, member B
FNBP4 formin binding protein 4
FNDC3B fibronectin type III domain containing 3B
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA2 GATA binding protein 2
GBP1 guanylate binding protein 1, interferon-inducible
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
GPATCH8 G patch domain containing 8
GSE1 Gse1 coiled-coil protein
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HIST1H2AE histone cluster 1, H2ae
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IGFBP7 insulin-like growth factor binding protein 7
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL6 interleukin 6
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
ING3 inhibitor of growth family, member 3
INPP1 inositol polyphosphate-1-phosphatase
INTS6 integrator complex subunit 6
IRF1 interferon regulatory factor 1
JMJD1C jumonji domain containing 1C
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM5B lysine (K)-specific demethylase 5B
KLF10 Kruppel-like factor 10
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KYNU kynureninase
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
MCL1 myeloid cell leukemia 1
MED13 mediator complex subunit 13
MMP9 matrix metallopeptidase 9
MTUS1 microtubule associated tumor suppressor 1
MYO6 myosin VI
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit
NAV3 neuron navigator 3
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NINJ1 ninjurin 1
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRIP1 nuclear receptor interacting protein 1
NUPL1 nucleoporin like 1
OASL 2'-5'-oligoadenylate synthetase-like
PER2 period circadian clock 2
PHIP pleckstrin homology domain interacting protein
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PPIE peptidylprolyl isomerase E (cyclophilin E)
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSPC1 paraspeckle component 1
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTBP2 polypyrimidine tract binding protein 2
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
RIOK3 RIO kinase 3
RLF rearranged L-myc fusion
RRAGD Ras-related GTP binding D
RSRC2 arginine/serine-rich coiled-coil 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A2 secretoglobin, family 2A, member 2
SELE selectin E
SIRT1 sirtuin 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SMIM7 small integral membrane protein 7
SNX11 sorting nexin 11
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SPEN spen family transcriptional repressor
SRSF11 serine/arginine-rich splicing factor 11
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TEX10 testis expressed 10
TFEC transcription factor EC
TFF3 trefoil factor 3 (intestinal)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLK2 tousled-like kinase 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNIP1 TNFAIP3 interacting protein 1
TRAFD1 TRAF-type zinc finger domain containing 1
TSC22D1 TSC22 domain family, member 1
TSC22D2 TSC22 domain family, member 2
TXNIP thioredoxin interacting protein
WAC WW domain containing adaptor with coiled-coil
WEE1 WEE1 G2 checkpoint kinase
WSB1 WD repeat and SOCS box containing 1
YTHDC1 YTH domain containing 1
ZBTB18 zinc finger and BTB domain containing 18
ZBTB20 zinc finger and BTB domain containing 20
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein
ZHX2 zinc fingers and homeoboxes 2
ZMYM2 zinc finger, MYM-type 2
ZNF451 zinc finger protein 451
ZNF804A zinc finger protein 804A

decreased expression

Symbol Name
ACLY ATP citrate lyase
AHCY adenosylhomocysteinase
AHNAK AHNAK nucleoprotein
AHNAK2 AHNAK nucleoprotein 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALOX5 arachidonate 5-lipoxygenase
ANXA4 annexin A4
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
B3GNT1
C14ORF132 chromosome 14 open reading frame 132
C6ORF62 chromosome 6 open reading frame 62
CALU calumenin
CANX calnexin
CCNG1 cyclin G1
CD53 CD53 molecule
CD99 CD99 molecule
COPA coatomer protein complex, subunit alpha
CTSH cathepsin H
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DHRS3 dehydrogenase/reductase (SDR family) member 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNTT DNA nucleotidylexotransferase
DPP4 dipeptidyl-peptidase 4
DPYSL2 dihydropyrimidinase-like 2
DSTN destrin (actin depolymerizing factor)
DTX4 deltex 4, E3 ubiquitin ligase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5 eukaryotic translation initiation factor 5
EMP2 epithelial membrane protein 2
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
EZR ezrin
FAM57A family with sequence similarity 57, member A
FBLN1 fibulin 1
FCGBP Fc fragment of IgG binding protein
FERMT1 fermitin family member 1
FGFR3 fibroblast growth factor receptor 3
FLNA filamin A, alpha
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
GDI2 GDP dissociation inhibitor 2
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPD1L glycerol-3-phosphate dehydrogenase 1-like
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGB3 high mobility group box 3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IGF2R insulin-like growth factor 2 receptor
IGFBP6 insulin-like growth factor binding protein 6
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IPO5 importin 5
IVNS1ABP influenza virus NS1A binding protein
KIAA0100 KIAA0100
KIF20A kinesin family member 20A
KRT19 keratin 19, type I
LASP1 LIM and SH3 protein 1
LPAR6 lysophosphatidic acid receptor 6
MAN1A1 mannosidase, alpha, class 1A, member 1
MAT2A methionine adenosyltransferase II, alpha
METTL7A methyltransferase like 7A
METTL9 methyltransferase like 9
MLEC malectin
MME membrane metallo-endopeptidase
MPZL1 myelin protein zero-like 1
MPZL2 myelin protein zero-like 2
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NELL2 NEL-like 2 (chicken)
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NT5DC2 5'-nucleotidase domain containing 2
OLFML3 olfactomedin-like 3
PCNA proliferating cell nuclear antigen
PDIA6 protein disulfide isomerase family A, member 6
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PEBP1 phosphatidylethanolamine binding protein 1
PEG10 paternally expressed 10
PGK1 phosphoglycerate kinase 1
PKM pyruvate kinase, muscle
PLBD1 phospholipase B domain containing 1
POSTN periostin, osteoblast specific factor
PRDX4 peroxiredoxin 4
PSAP prosaposin
PSAT1 phosphoserine aminotransferase 1
RAP2A RAP2A, member of RAS oncogene family
RBBP4 retinoblastoma binding protein 4
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE6 ribonuclease, RNase A family, k6
RNASET2 ribonuclease T2
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
RRM2 ribonucleotide reductase M2
S100A10 S100 calcium binding protein A10
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC1 syndecan 1
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SEPHS1 selenophosphate synthetase 1
SFN stratifin
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SPP1 secreted phosphoprotein 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SRSF1 serine/arginine-rich splicing factor 1
SSR1 signal sequence receptor, alpha
STARD7 StAR-related lipid transfer (START) domain containing 7
STEAP1 six transmembrane epithelial antigen of the prostate 1
TBC1D16 TBC1 domain family, member 16
TFDP1 transcription factor Dp-1
TFRC transferrin receptor
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
THBS1 thrombospondin 1
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM2 transmembrane protein 2
TMEM230 transmembrane protein 230
TMEM50B transmembrane protein 50B
TMEM97 transmembrane protein 97
TMPO thymopoietin
TPD52L1 tumor protein D52-like 1
TRAM1 translocation associated membrane protein 1
TSPAN13 tetraspanin 13
TUBB tubulin, beta class I
VCAN versican